Version2.0 2020-07-31T22:20:16Z 10.1021/jm300687e Gaussian16 RevisionB.01 SBUNGAY 14-Jul-2020 #N HF/6-31G(d) OPT=(MaxStep=1) FREQ IOp(6/10=2,6/11=2,6/12=2) DUDE C[C@@]1(C(=O)Nc2ccccc2O1)C(=O)Nc3cnn(c3)Cc4ccccc4Cl C41545887 RHF 6-31G(d) (6D,7F) C[C@@]1(C(=O)Nc2ccccc2O1)C(=O)Nc3cnn(c3)Cc4ccccc4Cl C01[X(C20H17Cl1N4O3)] 129 C1 458 Clc1ccccc1Cn1ncc(c1)NC(=O)[C@]1(C)Oc2ccccc2NC1=O Clc1ccccc1Cn1ncc(c1)NC(=O)[C@]1(C)Oc2ccccc2NC1=O C[C@]1(Oc2ccccc2NC1=O)C(=O)Nc3cnn(Cc4ccccc4Cl)c3 InChIKey=MDNQBQPAPMUKRU-FQEVSTJZSA-N InChI=1S/C20H17ClN4O3/c1-20(19(27)24-16-8-4-5-9-17(16)28-20)18(26)23-14-10-22-25(12-14)11-13-6-2-3-7-15(13)21/h2-10,12H,11H2,1H3,(H,23,26)(H,24,27)/t20-/m0/s1 InChI=1/C20H17ClN4O3/c1-20(19(27)24-16-8-4-5-9-17(16)28-20)18(26)23-14-10-22-25(12-14)11-13-6-2-3-7-15(13)21/h2-10,12H,11H2,1H3,(H,23,26)(H,24,27)/t20-/m0/s1/f/h23-24H C[C@@]1(C(=O)Nc2ccccc2O1)C(=O)Nc3cnn(c3)Cc4ccccc4Cl C01[X(C20H17Cl1N4O3)] 129 C01 458 Clc1ccccc1Cn1ncc(c1)NC(=O)[C@]1(C)Oc2ccccc2NC1=O Cl[C]1[CH][CH][CH][CH][C]1C[N]1[N][CH][C]([CH]1)NC(=O)[C@]1(C)O[C]2[CH][CH][CH][CH][C]2NC1=O C[C@]1(O[C]2[CH][CH][CH][CH][C]2NC1=O)C(=O)N[C]3[CH][N]N([CH]3)C[C]4[CH][CH][CH][CH][C]4Cl InChIKey=MDNQBQPAPMUKRU-FQEVSTJZSA-N InChI=1S/C20H17ClN4O3/c1-20(19(27)24-16-8-4-5-9-17(16)28-20)18(26)23-14-10-22-25(12-14)11-13-6-2-3-7-15(13)21/h2-10,12H,11H2,1H3,(H,23,26)(H,24,27)/t20-/m0/s1 InChI=1/C20H17ClN4O3/c1-20(19(27)24-16-8-4-5-9-17(16)28-20)18(26)23-14-10-22-25(12-14)11-13-6-2-3-7-15(13)21/h2-10,12H,11H2,1H3,(H,23,26)(H,24,27)/t20-/m0/s1/f/h23-24H 2654.6651173532 -1669.1366502 1-A 13812.1273 103 355 458 |A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A| -104.83763 -20.61731 -20.54203 -20.54110 -15.64400 -15.61169 -15.61036 -15.58382 -11.36526 -11.36396 -11.32791 -11.31257 -11.31039 -11.29832 -11.28722 -11.26864 -11.26713 -11.26408 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11.62379
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|XX|YY|ZZ|XY|XZ|YZ| -4.8630 0.2197 4.6433 -11.3982 8.1093 14.6222
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55.810968 24 6 7 8 19 4 1
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|1.849335|2.045543|1.893943|3.096203|2.633750|2.089154|2.112397|2.211721|2.297847|2.272628|2.165047|3.670923|2.378915|4.225824|3.627560|3.184843|3.404895|5.544573|5.824584|3.597167|5.022625|7.867741|13.795511|36.858105| |1.782476|1.969526|1.819271|2.959831|2.550523|2.053110|2.097166|2.247377|2.369548|2.311118|2.148745|3.609856|2.241171|3.904711|3.436027|2.931303|2.981441|4.666449|5.128844|3.360537|4.414233|6.805921|7.958424|13.743261|36.858105| |1.874965|2.061585|1.869866|3.022643|2.607023|2.119140|2.141036|2.319906|2.518348|2.488130|2.271285|3.838691|2.332897|3.976999|3.665330|3.127768|3.050242|4.757591|5.577563|3.754998|4.964099|7.859748|6.902403|7.954167|13.792729|36.858105| |2.076807|2.270486|2.014138|3.245973|2.763201|2.235911|2.205020|2.356338|2.593855|2.650664|2.440379|4.208002|2.617355|4.417401|4.246412|3.773407|3.624348|5.873391|7.514758|4.878271|7.429397|13.726775|8.017513|6.914012|7.967195|13.745627|36.858105| |2.146230|2.302584|2.003097|3.220421|2.723193|2.215470|2.153436|2.319774|2.636044|2.758377|2.490338|4.369094|2.583960|4.237469|4.268677|3.642724|3.276773|5.040576|6.640532|4.849492|6.050320|6.947729|4.745566|4.225628|4.785399|7.094450|10.860717|448.794386| |17.607176|8.883919|6.977447|11.765466|6.791928|4.380536|3.333557|2.934773|3.091980|3.869775|4.955525|12.977672|5.525577|8.147996|6.317393|3.510574|3.021404|3.468170|3.459298|2.989525|2.157642|1.974653|1.848937|1.696792|1.650043|1.735352|1.900239|15.870509|0.500000| |17.590806|8.871055|5.519833|8.790704|5.743215|4.006875|3.123395|2.851992|3.110635|3.982868|4.839684|13.046495|6.945582|9.356810|8.863533|4.662537|3.774150|4.254280|4.322849|3.895019|2.617570|2.317765|2.123205|1.905664|1.843153|1.963022|2.204812|18.656510|0.300307|0.500000| |17.640232|8.875595|6.944713|12.900233|6.369245|3.963795|3.088019|2.697554|2.784744|3.377814|4.255439|10.248711|6.990715|11.082071|7.261403|4.083879|3.643993|4.036178|3.880093|3.299498|2.360364|2.114519|1.995955|1.803113|1.719670|1.791092|1.981442|16.210527|0.300734|0.299352|0.500000| |4.254171|5.706923|9.488244|13.821870|26.015832|9.144058|7.121342|4.716005|3.997777|4.269198|5.813122|9.200389|4.735519|8.367843|5.088931|3.085432|2.879446|3.308493|3.161980|2.600487|1.994626|1.944831|1.916097|1.824899|1.765280|1.786944|1.873923|14.715071|0.117168|0.098295|0.111947|0.500000| |3.076765|3.993258|4.735707|7.009431|9.672210|8.938164|17.712280|8.893260|5.637685|4.949323|5.657253|7.519935|3.736800|6.427166|4.538398|2.911641|2.707299|3.227009|3.150660|2.570584|2.031107|2.062738|2.051239|2.011191|1.983040|1.994146|2.034648|15.754674|0.083667|0.077332|0.079294|0.210546|0.500000| |2.577767|3.187289|3.299201|4.977509|5.678775|5.656042|8.941877|17.729392|8.911540|5.646758|4.970023|6.515064|3.082659|5.101193|4.128856|2.753316|2.500568|3.103926|3.155766|2.583392|2.093806|2.197923|2.158925|2.170515|2.224446|2.270052|2.257433|17.651810|0.070150|0.068273|0.065341|0.111371|0.215048|0.500000| |2.778350|3.364434|3.137258|4.677647|4.946010|4.950753|5.641613|8.906671|17.732149|8.927485|5.664619|7.516532|3.246688|5.070147|4.710784|3.117084|2.667980|3.354979|3.590402|3.067404|2.394905|2.505706|2.346491|2.321746|2.449256|2.635513|2.670978|22.083219|0.075255|0.076871|0.068263|0.090809|0.123945|0.214390|0.500000| |3.980768|4.880298|3.971688|5.700627|5.760279|5.654557|4.950690|5.634998|8.859534|17.726432|8.985921|13.064135|4.457072|6.332779|6.877084|4.095959|3.209853|3.895526|4.266778|3.952300|2.723775|2.676368|2.412727|2.271375|2.332434|2.567644|2.776851|24.135420|0.106145|0.114800|0.091758|0.098503|0.107480|0.123799|0.213567|0.500000| |6.107928|7.649961|4.887233|7.003207|5.999309|4.896076|3.885963|3.732768|4.349410|5.961451|6.647540|14.949451|9.493693|10.893924|26.080361|9.255632|5.613873|6.058950|6.593533|7.152493|3.683067|3.272307|2.895447|2.547081|2.471456|2.689615|3.112654|26.221777|0.135402|0.195419|0.139852|0.099873|0.091449|0.086865|0.106097|0.177247|0.500000| |3.643545|4.160538|3.667766|5.999452|4.579303|3.294387|2.929642|2.702566|2.743583|3.043155|3.375845|6.299820|6.244922|13.690829|8.697853|8.520569|17.861988|12.523007|8.304983|5.882249|4.303905|3.708251|3.696757|3.074082|2.683466|2.683212|3.075201|22.317872|0.084260|0.101503|0.105279|0.084455|0.076753|0.067912|0.069432|0.081610|0.134239|0.500000| |3.365369|3.680767|2.926119|4.562808|3.816825|3.098008|2.801501|2.885235|3.341632|3.895192|3.694774|6.907362|4.481833|6.824603|8.908843|8.572624|5.852483|8.059846|12.256215|17.805886|6.773147|5.436444|4.139509|3.401211|3.326816|3.889386|5.130798|46.473325|0.081417|0.105820|0.085954|0.068532|0.068900|0.071780|0.089995|0.120100|0.193942|0.123590|0.500000| |2.272957|2.400620|2.109086|3.482786|2.767113|2.126680|2.014087|2.031083|2.168518|2.315753|2.289604|4.168239|2.905148|5.109432|4.681490|4.573526|5.107169|10.438249|12.753958|5.790230|17.646328|8.917744|7.134620|4.743004|3.996626|4.231974|5.694977|37.676778|0.056309|0.067642|0.062457|0.052157|0.052404|0.053083|0.059111|0.066450|0.089326|0.116787|0.141406|0.500000| |2.402145|2.524256|2.161531|3.521333|2.839230|2.225995|2.095501|2.152194|2.370505|2.570226|2.474329|4.531660|2.988520|5.011938|5.040233|4.808725|4.602104|8.062768|12.586255|7.042601|17.664679|8.830505|5.628110|4.179510|3.938385|4.662806|7.020446|57.253675|0.059745|0.073168|0.064412|0.052917|0.053601|0.055810|0.065449|0.076070|0.101048|0.102883|0.200591|0.303056|0.500000| |2.068493|2.268185|2.073904|3.414828|2.809613|2.175149|2.130758|2.157805|2.235710|2.291966|2.258868|3.941367|2.742482|4.985719|4.211823|3.946677|4.656929|8.703241|8.277503|4.429235|7.151704|8.957018|17.725412|8.937167|5.655601|4.967933|5.689645|31.421888|0.051770|0.059487|0.056912|0.053736|0.056343|0.057502|0.061027|0.063639|0.079238|0.114661|0.107715|0.213594|0.143868|0.500000| |1.748821|1.933237|1.818587|2.995570|2.537807|1.993712|2.030854|2.107469|2.148956|2.109013|2.032010|3.437457|2.237623|4.037855|3.333626|2.877740|3.142100|5.005702|4.994398|3.128199|4.108435|5.619752|8.938451|17.726834|8.902432|5.651560|4.974039|27.392894|0.044725|0.049610|0.047701|0.049309|0.054415|0.057946|0.059976|0.057913|0.064563|0.081247|0.081372|0.112518|0.096488|0.215683|0.500000| |1.650980|1.822215|1.704730|2.784140|2.408603|1.938419|2.006500|2.162912|2.256066|2.164392|2.007879|3.348964|2.042492|3.570126|3.078243|2.560632|2.598256|3.958722|4.251534|2.859556|3.534088|4.917622|5.650912|8.893670|17.724083|8.948958|5.661973|31.769672|0.042791|0.047127|0.044271|0.046671|0.053133|0.060365|0.065291|0.060297|0.061772|0.066234|0.079043|0.090934|0.089775|0.124182|0.213941|0.500000| |1.789065|1.958691|1.781879|2.880884|2.496489|2.041410|2.077088|2.282384|2.499999|2.443168|2.196443|3.695016|2.171985|3.673188|3.389138|2.806456|2.683701|4.064280|4.728709|3.321881|4.058272|5.624121|4.969988|5.646779|8.903305|17.750519|8.937959|54.880352|0.046417|0.052046|0.047220|0.047629|0.053646|0.062519|0.074109|0.070598|0.070216|0.066297|0.098168|0.097600|0.111019|0.107824|0.124026|0.214873|0.500000|
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