Version2.1 2021-01-13T23:21:01Z 10.1021/jm300687e Gaussian16 RevisionB.01 PWARBURT 28-Dec-2020 #N HF/6-31G(d) OPT=(MaxStep=1) FREQ IOp(6/10=2,6/11=2,6/12=2) DUDE C[C@@H]1CN(C[C@@H](O1)C)C(=O)CSC2=NC(=O)[C@@H](C(=N2)NC(=O)C)NC(=O)c3ccccc3 C39373255 RHF 6-31G(d) (6D,7F) C[C@@H]1CN(C[C@@H](O1)C)C(=O)CSC2=NC(=O)[C@@H](C(=N2)NC(=O)C)NC(=O)c3ccccc3 C01[X(C21H25N5O5S1)] 165 C1 534 C[C@@H]1O[C@H](C)CN(C1)C(=O)CSC1=NC(=O)[C@@H](C(=N1)NC(=O)C)NC(=O)c1ccccc1 C[C@@H]1O[C@H](C)CN(C1)C(=O)CSC1=NC(=O)[C@@H](C(=N1)NC(=O)C)NC(=O)c1ccccc1 C[C@H]1CN(C[C@@H](C)O1)C(=O)CSC2=NC(=O)[C@H](NC(=O)c3ccccc3)C(=N2)NC(C)=O InChIKey=BWNKFTBOBNMXIV-IIYDPXPESA-N InChI=1S/C21H25N5O5S/c1-12-9-26(10-13(2)31-12)16(28)11-32-21-24-18(22-14(3)27)17(20(30)25-21)23-19(29)15-7-5-4-6-8-15/h4-8,12-13,17H,9-11H2,1-3H3,(H,23,29)(H,22,24,25,27,30)/t12-,13+,17-/m1/s1 InChI=1/C21H25N5O5S/c1-12-9-26(10-13(2)31-12)16(28)11-32-21-24-18(22-14(3)27)17(20(30)25-21)23-19(29)15-7-5-4-6-8-15/h4-8,12-13,17H,9-11H2,1-3H3,(H,23,29)(H,22,24,25,27,30)/t12-,13+,17-/m1/s1/f/h22-23H C[C@@H]1CN(C[C@@H](O1)C)C(=O)CSC2=NC(=O)[C@@H](C(=N2)NC(=O)C)NC(=O)c3ccccc3 C01[X(C21H25N5O5S1)] 165 C01 534 C[C@@H]1O[C@H](C)CN(C1)C(=O)CSC1=NC(=O)[C@@H](C(=N1)NC(=O)C)NC(=O)c1ccccc1 C[C@@H]1O[C@H](C)CN(C1)C(=O)CS[C]1[N][C](=O)[C@@H](C(=N1)NC(=O)C)NC(=O)[C]1[CH][CH][CH][CH][CH]1 C[C@H]1CN(C[C@@H](C)O1)C(=O)CS[C]2[N]C(=O)[C@H](NC(=O)[C]3[CH][CH][CH][CH][CH]3)C(=N2)NC(C)=O InChIKey=BWNKFTBOBNMXIV-IIYDPXPESA-N InChI=1S/C21H25N5O5S/c1-12-9-26(10-13(2)31-12)16(28)11-32-21-24-18(22-14(3)27)17(20(30)25-21)23-19(29)15-7-5-4-6-8-15/h4-8,12-13,17H,9-11H2,1-3H3,(H,23,29)(H,22,24,25,27,30)/t12-,13+,17-/m1/s1 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MUNgauss RevisionA2.0 retrievium 13-Jan-2021 DUDE C[C@@H]1CN(C[C@@H](O1)C)C(=O)CSC2=NC(=O)[C@@H](C(=N2)NC(=O)C)NC(=O)c3ccccc3 C39373255 RHF 6-31G(d) (6D,10F) C1 459.157641 |X|Y|Z| 148.041516 64.261589 18.564293
56.105375 23 6 7 8 16 17 4 1 1
|36.858105| |12.557150|36.858105| |8.876364|17.485457|0.500000| |7.540078|12.511390|0.248115|36.858105| |5.019848|7.812371|0.195563|13.075070|53.358707| |4.507553|6.700649|0.164581|7.803822|17.825771|36.858105| |5.211154|8.083524|0.203431|6.705344|10.633667|12.479864|36.858105| |4.802330|7.320278|0.223412|5.929800|9.593834|8.934735|17.478648|0.500000| |8.073646|13.538848|0.259599|7.938691|9.337624|7.937354|13.590685|0.259768|73.516695| |4.054110|5.206350|0.133381|4.508414|6.834646|7.535503|12.553346|0.246459|14.364878|36.858105| |3.901882|5.277701|0.144092|7.856607|19.097551|7.617882|5.202539|0.142251|8.224516|3.843237|36.858105| |3.764726|4.739044|0.131194|6.988930|11.542187|5.301354|4.110828|0.113920|7.000748|3.167292|15.859340|73.516695| |3.066177|3.949904|0.110135|5.008443|10.572913|6.565479|4.560918|0.127578|6.743383|3.667856|12.524345|14.289925|36.858105| |2.517028|3.035346|0.086034|3.709819|6.486871|4.059962|3.209675|0.091298|5.059510|2.723340|7.001309|12.056659|10.506037|388.023441| |2.140277|2.538151|0.071859|2.937062|5.016441|3.492405|2.856143|0.081397|4.415592|2.556020|4.656616|7.588316|7.009041|77.679208|36.858105| |2.145401|2.566683|0.072318|2.910295|5.059075|3.764400|3.070857|0.087227|4.607139|2.818263|4.416598|6.795830|6.813976|51.188892|14.826909|53.358707| |1.878579|2.198567|0.061915|2.426092|4.042519|3.076421|2.626290|0.074530|3.992850|2.501639|3.360321|5.334123|4.592111|34.698451|8.411325|18.956628|36.858105| |1.819702|2.123583|0.059877|2.289889|3.778385|2.970544|2.606923|0.074214|3.927780|2.555660|3.018555|4.753728|3.957465|27.710264|5.676105|11.472669|15.959541|73.516695| |1.682956|1.928352|0.054132|2.133016|3.439042|2.549094|2.206167|0.062216|3.455304|2.101987|2.874455|4.760498|3.699507|30.641320|7.043073|10.480523|12.416783|14.341327|36.858105| |1.664906|1.896755|0.052626|2.114855|3.389132|2.522151|2.161555|0.060025|3.408630|2.071240|2.818502|4.677928|3.577240|29.086820|6.171074|9.048910|8.972881|11.677734|17.484421|0.500000| |1.706700|1.949775|0.055115|2.180958|3.489602|2.488052|2.150647|0.061095|3.417208|2.001229|3.010952|5.154490|3.826199|35.982473|8.406398|9.325922|7.621492|9.537941|12.480053|0.252246|36.858105| |1.891604|2.185981|0.062047|2.491326|4.050341|2.802523|2.378273|0.067853|3.774441|2.159032|3.647678|6.308361|4.784760|52.734875|13.837357|10.806537|6.865675|8.630452|7.794776|0.182120|14.960484|53.358707| |1.539541|1.730430|0.048932|1.916681|2.987411|2.122143|1.870763|0.053111|3.020938|1.752776|2.534066|4.435690|3.053130|27.889182|5.378763|6.276266|5.130494|7.305461|7.811289|0.185487|14.079937|11.239521|53.358707| |1.490675|1.659719|0.047122|1.836538|2.813389|1.963326|1.747500|0.049771|2.861565|1.624686|2.392235|4.298782|2.781306|25.839380|4.440400|5.046622|3.853859|5.733943|5.014230|0.126402|7.683438|8.887696|18.490608|36.858105| |1.567077|1.747105|0.049917|1.941759|2.966890|2.032522|1.809329|0.051837|2.976111|1.660277|2.558647|4.684030|2.939379|28.404582|4.580214|4.995365|3.612963|5.382630|4.332650|0.108956|6.545792|9.138886|11.343756|16.106998|73.516695| |1.336507|1.469411|0.041559|1.610369|2.427121|1.708229|1.539440|0.043645|2.543470|1.447303|2.021169|3.636858|2.292094|20.199632|3.327019|3.993828|3.109241|4.837443|3.970065|0.104827|5.105919|5.938141|10.722451|12.599896|14.218017|36.858105| |1.522140|1.724984|0.048611|1.869308|2.956363|2.215558|1.974012|0.055952|3.110377|1.913918|2.405124|4.007981|2.967632|23.548130|4.745411|7.110263|7.909410|12.919367|13.223439|0.254164|7.542752|7.127621|9.026344|4.521735|6.779002|3.882795|53.358707| |1.387257|1.551687|0.043512|1.676121|2.603221|1.946432|1.749552|0.049241|2.795462|1.708316|2.097311|3.541061|2.507671|19.813388|3.710903|5.332218|5.212232|8.856625|7.746648|0.200693|5.712405|5.668242|8.095908|4.286227|6.226012|4.031528|19.165457|36.858105| |1.357586|1.509514|0.042157|1.643188|2.532575|1.871690|1.673434|0.046838|2.700424|1.623735|2.054281|3.513186|2.428266|19.618627|3.587550|4.922884|4.489337|7.262644|6.781114|0.197838|5.737640|5.681635|9.004924|4.775837|6.658619|4.714193|11.609884|15.734263|73.516695| |1.286091|1.428827|0.040105|1.521972|2.339376|1.766935|1.616980|0.045568|2.591636|1.600719|1.850208|3.119490|2.168469|16.589120|2.961730|4.323321|4.070569|7.528230|5.055250|0.133091|4.015369|4.348830|5.664248|3.328956|5.033907|3.270874|10.667881|12.749358|14.309795|36.858105| |1.181806|1.300565|0.036479|1.381527|2.096321|1.572363|1.449289|0.040785|2.348964|1.434157|1.652622|2.817269|1.899341|14.596393|2.515085|3.570459|3.184048|5.762449|3.875289|0.104989|3.354926|3.735673|4.969999|3.091824|4.670608|3.220510|7.123693|7.718862|12.017607|13.697625|36.858105| |1.108209|1.213121|0.034037|1.277342|1.923972|1.450185|1.351985|0.038061|2.199027|1.348480|1.500292|2.556774|1.703032|12.864472|2.163835|3.088522|2.694618|4.987723|3.098747|0.084048|2.727491|3.149288|3.955958|2.551845|3.967233|2.660296|5.398614|5.079845|8.084370|7.923804|13.780625|36.858105| |1.116803|1.224398|0.034380|1.280179|1.931000|1.470059|1.380273|0.038909|2.235196|1.389329|1.492532|2.524414|1.694443|12.557332|2.106360|3.064910|2.684505|5.138891|2.955813|0.079481|2.552089|2.995391|3.575955|2.302379|3.650298|2.333160|5.123569|4.464185|6.794584|6.866904|7.946450|13.737298|36.858105| |1.202900|1.328783|0.037337|1.388660|2.114491|1.624364|1.521844|0.042963|2.439870|1.538391|1.631982|2.732772|1.875594|13.745017|2.345531|3.498245|3.150185|6.265467|3.385262|0.089724|2.804780|3.280213|3.803829|2.391689|3.810152|2.348818|6.052580|5.020669|7.133544|7.922848|6.871894|7.929687|13.752023|36.858105| |1.299075|1.446715|0.040648|1.526054|2.350771|1.802414|1.665341|0.047022|2.650407|1.669835|1.834522|3.059237|2.149169|15.930499|2.815806|4.254142|4.029609|8.068167|4.488528|0.116740|3.504740|3.962751|4.681490|2.820714|4.423205|2.709397|8.889854|7.519134|9.415332|13.693246|7.922057|6.866788|7.941563|13.760525|36.858105| |17.563844|8.853316|0.173544|6.855116|6.358828|4.347543|4.809335|0.117085|12.890546|3.950259|3.664859|6.273388|2.923812|17.126778|2.065261|2.826882|1.827710|3.148227|1.645751|0.045623|1.660030|2.490131|2.042089|1.449060|2.693108|1.305156|2.025113|1.363192|2.379718|1.264481|1.163861|1.091966|1.099749|1.182920|1.276179|0.500000| |17.583144|8.881374|0.213685|5.504157|5.666421|3.963363|4.868125|0.128643|13.040200|4.010235|3.330444|5.668874|2.734927|16.168778|1.976860|2.718511|1.771203|3.081026|1.587068|0.043461|1.601029|2.393930|1.974965|1.404901|2.617991|1.265813|1.973376|1.324176|2.295312|1.236555|1.138352|1.072647|1.084928|1.168290|1.255015|0.301280|0.500000| |17.553888|8.836541|0.212529|6.833370|6.243906|3.901101|4.243729|0.113365|10.229163|3.361944|3.797295|6.858376|2.952955|17.815266|2.101318|2.820520|1.814277|3.100617|1.642619|0.045077|1.686094|2.555506|2.082606|1.495366|2.813553|1.341493|2.021176|1.356857|2.371107|1.255059|1.157707|1.084376|1.088330|1.167337|1.260679|0.300141|0.300526|0.500000| |7.023517|8.880185|0.174514|17.500178|12.402401|6.913168|5.800113|0.134836|12.526146|4.292714|6.357439|10.376684|4.437770|24.107092|2.746267|3.720840|2.308791|3.880106|2.052345|0.057307|2.082809|3.202099|2.505696|1.760716|3.283219|1.556741|2.451191|1.629450|2.855563|1.481765|1.349435|1.249093|1.250511|1.352966|1.483533|0.210086|0.142589|0.173554|0.500000| |6.718670|8.831870|0.216887|17.686622|12.528135|5.685781|5.024502|0.133511|10.161852|3.638110|7.648040|14.755589|4.759841|27.061653|2.915345|3.815781|2.338881|3.882240|2.090345|0.057382|2.180683|3.425031|2.628939|1.876214|3.567651|1.642365|2.491676|1.646395|2.886499|1.490021|1.359117|1.254475|1.250740|1.349597|1.483012|0.164769|0.138845|0.198343|0.301107|0.500000| |4.290894|5.794465|0.134724|6.905918|12.395805|17.496870|8.876789|0.174614|12.527488|7.028559|6.212959|8.317677|5.513409|26.107145|3.224942|4.731303|2.904599|4.994617|2.450130|0.068675|2.368795|3.581673|2.771333|1.880338|3.431423|1.651567|2.903994|1.897572|3.265833|1.726077|1.541762|1.423984|1.442080|1.588832|1.757956|0.122377|0.104303|0.102598|0.201328|0.141743|0.500000| |3.636120|5.017646|0.133272|5.653117|12.371657|17.659878|8.901807|0.218482|10.199800|6.806781|7.169576|8.788244|7.769715|31.873675|4.042135|6.240386|3.656452|6.316577|2.906885|0.079190|2.782623|4.262089|3.167083|2.116838|3.870762|1.825265|3.404673|2.159964|3.651892|1.950423|1.714047|1.573289|1.600307|1.786342|2.001589|0.097079|0.091756|0.090258|0.141222|0.127528|0.301646|0.500000| |3.361519|4.240033|0.113327|3.900572|6.244061|6.826955|8.823612|0.212395|10.232861|17.549200|3.721096|5.408558|3.783878|19.942806|2.720333|4.201691|2.765657|5.127603|2.275497|0.061965|2.128782|3.100159|2.518196|1.696216|3.062055|1.507072|2.829802|1.840145|3.078605|1.728557|1.535293|1.443046|1.495885|1.672091|1.821053|0.090689|0.092016|0.080382|0.102619|0.090382|0.173616|0.201410|0.500000| |4.010789|4.864514|0.128675|3.964851|5.668449|5.502484|8.887912|0.213607|13.052220|17.586778|3.295282|4.997642|3.121410|17.191041|2.278291|3.380116|2.241554|4.092767|1.909670|0.052051|1.827582|2.667728|2.203568|1.511595|2.749616|1.355561|2.398469|1.583431|2.675047|1.496799|1.349577|1.277187|1.319097|1.454855|1.565078|0.106970|0.116252|0.092035|0.104344|0.091712|0.142667|0.140172|0.300621|0.500000| |3.950388|4.805052|0.117067|4.347647|6.358973|6.849004|8.852072|0.173499|12.899227|17.564110|3.615370|5.373159|3.430335|18.395312|2.430586|3.630900|2.384726|4.311195|2.030505|0.056337|1.926844|2.814366|2.307510|1.571048|2.841582|1.407583|2.513683|1.663771|2.829041|1.559451|1.402291|1.319404|1.356784|1.497109|1.621858|0.112619|0.106969|0.090701|0.122412|0.097100|0.210159|0.166468|0.300018|0.301402|0.500000| |3.003894|3.916700|0.113106|4.595322|9.474896|6.601913|4.898377|0.145202|6.878622|3.956917|8.821126|10.950701|17.640090|56.560432|6.656906|9.797450|4.887343|7.755264|3.734493|0.097107|3.764570|6.231350|4.081513|2.710801|5.069558|2.238808|4.167857|2.545010|4.291552|2.225463|1.933893|1.742064|1.749699|1.954725|2.239577|0.078328|0.076048|0.079528|0.110670|0.119363|0.144859|0.240643|0.117115|0.093687|0.098924|0.500000| |2.913095|3.678665|0.098959|4.619593|9.352404|6.731942|4.471014|0.118769|6.561099|3.775219|8.840347|11.043509|17.626774|56.427474|6.623883|9.701880|4.859499|7.474147|3.864213|0.107580|3.806993|6.203961|4.117352|2.698516|4.942969|2.252590|4.171380|2.601921|4.485226|2.244684|1.955247|1.750167|1.744529|1.939488|2.231346|0.079166|0.072430|0.076807|0.120965|0.117590|0.171931|0.231392|0.109758|0.087459|0.101104|0.304054|0.500000| |1.450473|1.621135|0.045646|1.782806|2.760816|1.988185|1.764454|0.049853|2.853065|1.674119|2.300943|4.000512|2.743418|23.850974|4.485498|5.603873|4.816878|7.160689|7.659871|0.193144|9.563353|8.236806|25.896750|9.266188|10.801438|7.705958|10.252576|7.763581|17.340380|5.013129|4.411044|3.355603|2.950037|3.106465|3.888747|0.039433|0.038116|0.039912|0.047894|0.049596|0.053441|0.060487|0.049225|0.043054|0.045193|0.075191|0.076859|0.500000| |1.282805|1.409818|0.039953|1.530770|2.307582|1.640952|1.490861|0.042380|2.455667|1.412449|1.900536|3.385963|2.159098|18.526776|3.094887|3.832847|3.069322|4.883513|3.923188|0.101654|4.743178|5.354195|9.668729|8.861659|10.968274|17.552908|5.584906|4.408143|9.016158|3.655671|3.685983|3.007740|2.589383|2.574619|2.964838|0.034769|0.033914|0.035650|0.041063|0.043136|0.044022|0.048881|0.041040|0.036867|0.038086|0.059402|0.059102|0.214389|0.500000| |1.314771|1.441114|0.040476|1.585297|2.383512|1.683798|1.510757|0.042506|2.501881|1.426114|1.978023|3.554429|2.237272|19.496516|3.195415|3.876299|3.023438|4.707948|3.905854|0.108195|4.812117|5.568740|9.597171|8.874303|10.993631|17.556484|5.144918|4.074352|8.993587|3.280718|3.271516|2.683892|2.330884|2.331748|2.687536|0.035863|0.034531|0.036600|0.042906|0.044779|0.045625|0.049856|0.041203|0.037021|0.038774|0.060090|0.061962|0.209507|0.301629|0.500000| |1.304021|1.425018|0.040392|1.558379|2.325209|1.623779|1.472281|0.041813|2.451164|1.379218|1.933278|3.519881|2.152878|18.933971|2.988053|3.573240|2.716811|4.276440|3.307488|0.087678|4.173472|5.187018|7.789243|8.981967|13.458805|17.647875|4.379052|3.291444|6.619922|2.781493|2.769012|2.358714|2.092172|2.094739|2.367682|0.035322|0.034330|0.036547|0.041808|0.044450|0.043560|0.047795|0.039667|0.036034|0.037247|0.058312|0.058251|0.150133|0.299301|0.299071|0.500000| |1.535719|1.746468|0.049409|1.872082|2.969773|2.256271|2.032049|0.057949|3.174702|1.988154|2.384358|3.929507|2.941858|22.484412|4.435031|7.014122|8.033001|15.809682|9.306237|0.190811|5.946645|6.249234|7.003923|3.817910|5.973910|3.317963|26.051645|9.388681|10.885689|7.449646|4.903369|3.930963|3.939229|4.932064|7.475814|0.041580|0.040833|0.041432|0.049886|0.050616|0.059984|0.071367|0.060622|0.050965|0.052936|0.086447|0.084122|0.153115|0.097854|0.088737|0.078738|0.500000| |1.165815|1.279220|0.035849|1.365515|2.064267|1.534432|1.409126|0.039598|2.296508|1.385205|1.637293|2.814396|1.872924|14.627352|2.501824|3.470588|3.032548|5.316531|3.791080|0.104328|3.428807|3.797806|5.314143|3.359133|4.971660|3.654980|6.626426|7.236606|13.459839|8.944731|17.753757|8.903778|5.644827|4.954476|5.649854|0.031918|0.031116|0.031842|0.037106|0.037500|0.041854|0.046213|0.040936|0.036194|0.037700|0.052470|0.053413|0.135007|0.118358|0.105286|0.086128|0.120731|0.500000| |1.047401|1.140305|0.031979|1.199187|1.793577|1.346120|1.259139|0.035415|2.061239|1.254478|1.396617|2.394210|1.569614|11.882476|1.965463|2.771419|2.366100|4.326380|2.705060|0.073973|2.451682|2.870332|3.600534|2.385123|3.727709|2.542599|4.524150|4.141086|6.990319|5.640582|8.932644|17.725615|8.906357|5.641938|4.949417|0.028695|0.028185|0.028536|0.032632|0.032808|0.036784|0.040295|0.037092|0.033112|0.034164|0.044404|0.044679|0.084135|0.079951|0.071630|0.063445|0.090477|0.214535|0.500000| |1.060266|1.156943|0.032484|1.203222|1.803489|1.374489|1.300274|0.036646|2.114655|1.314218|1.385358|2.347201|1.557485|11.458544|1.890009|2.740764|2.353482|4.503404|2.539602|0.068591|2.233886|2.669751|3.122300|2.049085|3.289071|2.084886|4.240857|3.565865|5.610039|4.948945|5.650912|8.913036|17.718764|8.921684|5.649251|0.029019|0.028701|0.028700|0.032687|0.032650|0.037505|0.041348|0.039215|0.034836|0.035689|0.044689|0.044457|0.070461|0.063839|0.057822|0.052657|0.090686|0.124086|0.214811|0.500000| |1.201465|1.326796|0.037296|1.376497|2.093118|1.621432|1.532321|0.043294|2.451359|1.563460|1.600428|2.667216|1.830794|13.186518|2.223054|3.349797|2.975319|6.055486|3.062288|0.081161|2.553363|3.051892|3.402086|2.163864|3.503259|2.104974|5.241795|4.085559|5.958179|5.641589|4.952378|5.640925|8.908762|17.728190|8.933036|0.032812|0.032537|0.032281|0.037240|0.037010|0.044043|0.049557|0.047422|0.041224|0.042208|0.053368|0.052612|0.075517|0.063331|0.057864|0.052752|0.121404|0.107567|0.124049|0.214924|0.500000| |1.388122|1.558173|0.043794|1.642810|2.556943|1.981429|1.825131|0.051592|2.872697|1.837673|1.990495|3.280454|2.364009|17.224979|3.094639|4.850622|4.771990|10.294487|4.976107|0.126869|3.699938|4.228260|4.704793|2.801202|4.457148|2.609711|9.697415|6.865008|8.628177|8.849681|5.625487|4.949669|5.661079|8.970890|17.719678|0.037832|0.037238|0.037253|0.044245|0.044081|0.053503|0.061866|0.056252|0.047601|0.049389|0.069205|0.068574|0.105392|0.077782|0.071553|0.063618|0.258860|0.123962|0.107480|0.124543|0.217156|0.500000|
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