Version2.1 2020-12-28T01:55:21Z 10.1021/jm300687e Gaussian16 RevisionB.01 CFLINN 19-Nov-2020 #N HF/6-31G(d) OPT=(MaxStep=1) FREQ IOp(6/10=2,6/11=2,6/12=2) DUDE CC(=O)c1ccc(cc1)c2ccc(o2)[C@@H]3[C@@H]([C@@](NC(=O)N3)(C(F)(F)F)O)C(=O)c4cccs4 C35092955 RHF 6-31G(d) (6D,7F) CC(=O)c1ccc(cc1)c2ccc(o2)[C@@H]3[C@@H]([C@@](NC(=O)N3)(C(F)(F)F)O)C(=O)c4cccs4 C01[X(C22H17F3N2O5S1)] 144 C1 533 O=C1N[C@H](c2ccc(o2)c2ccc(cc2)C(=O)C)[C@@H]([C@](N1)(O)C(F)(F)F)C(=O)c1cccs1 O=C1N[C@H](c2ccc(o2)c2ccc(cc2)C(=O)C)[C@@H]([C@](N1)(O)C(F)(F)F)C(=O)c1cccs1 CC(=O)c1ccc(cc1)c2oc(cc2)[C@H]3NC(=O)N[C@](O)([C@H]3C(=O)c4sccc4)C(F)(F)F InChIKey=KZLUMMBAIZJELT-OPYAIIAOSA-N InChI=1S/C22H17F3N2O5S/c1-11(28)12-4-6-13(7-5-12)14-8-9-15(32-14)18-17(19(29)16-3-2-10-33-16)21(31,22(23,24)25)27-20(30)26-18/h2-10,17-18,31H,1H3,(H2,26,27,30)/t17-,18-,21+/m1/s1 InChI=1/C22H17F3N2O5S/c1-11(28)12-4-6-13(7-5-12)14-8-9-15(32-14)18-17(19(29)16-3-2-10-33-16)21(31,22(23,24)25)27-20(30)26-18/h2-10,17-18,31H,1H3,(H2,26,27,30)/t17-,18-,21+/m1/s1/f/h26-27H CC(=O)c1ccc(cc1)c2ccc(o2)[C@@H]3[C@@H]([C@@](NC(=O)N3)(C(F)(F)F)O)C(=O)c4cccs4 C01[X(C22H17F3N2O5S1)] 144 C01 533 O=C1N[C@H](c2ccc(o2)c2ccc(cc2)C(=O)C)[C@@H]([C@](N1)(O)C(F)(F)F)C(=O)c1cccs1 O=C1N[C@H](C2=[CH][CH]=C(O2)[C]2[CH][CH][C]([CH][CH]2)C(=O)C)[C@@H]([C@](N1)(O)C(F)(F)F)C(=O)C1=[CH][CH]=[CH]S1 CC(=O)[C]1[CH][CH][C]([CH][CH]1)c2oc(cc2)[C@H]3NC(=O)N[C@](O)([C@H]3C(=O)c4sccc4)C(F)(F)F InChIKey=KZLUMMBAIZJELT-OPYAIIAOSA-N InChI=1S/C22H17F3N2O5S/c1-11(28)12-4-6-13(7-5-12)14-8-9-15(32-14)18-17(19(29)16-3-2-10-33-16)21(31,22(23,24)25)27-20(30)26-18/h2-10,17-18,31H,1H3,(H2,26,27,30)/t17-,18-,21+/m1/s1 InChI=1/C22H17F3N2O5S/c1-11(28)12-4-6-13(7-5-12)14-8-9-15(32-14)18-17(19(29)16-3-2-10-33-16)21(31,22(23,24)25)27-20(30)26-18/h2-10,17-18,31H,1H3,(H2,26,27,30)/t17-,18-,21+/m1/s1/f/h26-27H 3730.1194809022 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MUNgauss RevisionA2.0 retrievium 28-Dec-2020 DUDE CC(=O)c1ccc(cc1)c2ccc(o2)[C@@H]3[C@@H]([C@@](NC(=O)N3)(C(F)(F)F)O)C(=O)c4cccs4 C35092955 RHF 6-31G(d) (6D,10F) C1 478.081028 |X|Y|Z| 52.840352 42.224881 109.716445
62.555949 23 6 7 8 16 19 2 1 1
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|1.530489|1.711208|3.026312|1.925119|2.188690|2.520333|2.454123|2.099514|1.896431|2.786775|2.661183|3.100806|3.722981|6.029606|4.910033|0.128666|7.393937|0.186145|12.405749|10.759602|5.168300|7.397285|6.163353|36.858105| |1.506398|1.671250|2.939174|1.877503|2.106351|2.412732|2.388923|2.070446|1.867352|2.717089|2.647333|3.074643|3.552800|5.706819|4.411736|0.119397|6.598781|0.199485|8.104548|7.270115|4.005375|5.885857|5.179133|14.483961|97.533100| |1.393557|1.544623|2.741242|1.715282|1.927204|2.178734|2.125020|1.851120|1.689719|2.380227|2.300709|2.655914|3.089429|5.017954|3.968840|0.108863|5.130109|0.133124|8.155287|9.322791|4.580150|6.956219|5.268934|14.368074|20.046649|97.533100| |1.594318|1.801731|3.223106|2.016886|2.326647|2.654653|2.505549|2.131173|1.950550|2.762268|2.558634|2.874788|3.476183|5.971679|4.332779|0.108025|6.246242|0.150885|7.992273|9.257596|4.893849|7.363861|5.717342|14.474283|20.132753|20.143284|97.533100| |1.509171|1.666459|2.896073|1.896383|2.118407|2.480590|2.532181|2.177618|1.920477|3.027179|3.051087|3.850853|4.551677|6.564507|6.768545|0.217397|8.169763|0.219685|13.625973|11.071970|5.850331|7.835613|7.768860|8.136399|15.779465|16.028409|12.146391|73.516695| |2.025816|2.346974|4.102301|2.778577|3.339258|4.187366|3.969289|3.114778|2.715179|4.662415|4.025071|4.562115|6.302899|11.504965|7.434267|0.153432|12.419646|0.244150|7.381775|8.324957|5.721069|7.943481|8.394343|6.239059|12.669562|9.931763|15.058274|9.093758|36.858105| |2.079661|2.447445|4.348536|2.880461|3.568801|4.436455|3.936592|3.067083|2.732798|4.369929|3.638525|3.962595|5.394172|10.738181|6.252807|0.130878|8.015216|0.163093|6.306759|8.620949|6.405839|9.317290|8.614794|5.487510|10.394176|9.362486|14.558868|7.831924|15.965957|73.516695| |2.113459|2.443411|4.253110|2.887583|3.418471|4.182671|4.002520|3.218082|2.829363|4.500050|3.929395|4.185873|5.157365|9.792249|5.200677|0.119190|7.330401|0.199363|5.087952|5.739139|3.961841|5.910066|5.827941|4.945061|11.535936|8.285811|12.082384|7.175739|12.858277|14.578494|36.858105| |2.272523|2.671019|4.724833|3.117635|3.747877|4.379589|3.942069|3.229888|2.950917|4.040779|3.439722|3.442862|4.051147|8.202618|3.941106|0.092859|4.927299|0.132031|3.884653|4.717249|3.341831|5.242931|4.776692|3.942736|9.054920|7.021202|10.179600|5.653208|7.622349|11.961488|14.062703|36.858105| |2.254002|2.592424|4.551858|2.962872|3.381831|3.759260|3.532055|3.064732|2.850254|3.546490|3.152175|3.084144|3.406103|6.681389|3.234715|0.079612|3.883511|0.110787|3.180051|3.837330|2.709318|4.316242|3.888883|3.287741|7.923355|6.072650|8.155990|4.886869|5.099241|7.996703|8.205834|13.362723|36.858105| |2.088104|2.341610|4.039649|2.682803|2.966734|3.346402|3.339879|2.951604|2.681345|3.517361|3.288378|3.282509|3.510511|6.533189|3.318945|0.083773|4.018940|0.122503|3.245778|3.778360|2.631612|4.133145|3.836140|3.342297|8.470273|6.159322|7.870979|5.151922|4.840341|7.135635|7.714428|8.268889|14.116241|36.858105| |1.967430|2.203997|3.776296|2.571007|2.877195|3.405081|3.507911|2.994414|2.616504|4.028539|3.872263|4.172936|4.594904|7.950499|4.466600|0.112235|5.880705|0.199230|4.330780|4.699914|3.200886|4.828267|4.783220|4.296990|11.316772|7.517730|9.527043|6.842426|6.645579|8.588889|10.958564|7.452426|7.456304|11.109010|388.023441| |17.631926|8.979811|13.747236|5.466657|4.136226|3.251950|3.064736|3.507361|4.701967|2.484633|2.232355|1.937911|1.954322|3.984691|1.745298|0.044911|1.691519|0.045569|1.515487|2.070453|1.627558|2.858195|2.366650|1.440136|3.186778|2.968417|3.387042|2.505957|1.866606|3.422523|1.943747|2.099502|2.089338|1.929968|12.870238|0.500000| |17.553761|8.837630|11.015975|6.609523|4.555625|3.664555|3.628899|4.453963|6.426253|2.874545|2.590352|2.190796|2.175514|4.461415|1.901902|0.049002|1.802437|0.048527|1.599541|2.186716|1.740042|3.045474|2.575142|1.495395|3.302546|3.074768|3.479337|2.660123|1.963633|3.579798|2.020533|2.133805|2.096895|1.967309|13.430606|0.299475|0.500000| |17.551450|8.839774|11.045530|6.588172|4.534457|3.650589|3.619885|4.449243|6.427263|2.869467|2.593518|2.189578|2.169034|4.441421|1.894607|0.048772|1.833067|0.049897|1.614459|2.174213|1.703361|2.945951|2.515903|1.526639|3.411329|3.119716|3.564901|2.679272|2.019953|3.635005|2.140875|2.304036|2.331734|2.180108|14.433095|0.299603|0.301712|0.500000| |4.582742|7.184977|13.823378|8.954907|17.756955|8.931385|5.636859|4.964799|5.665937|4.128361|3.226363|2.820262|3.103007|7.062444|2.747534|0.066593|2.684641|0.069046|2.318781|3.225945|2.609949|4.560592|3.819046|2.163782|4.649308|4.310911|5.262500|3.633884|3.224744|6.309379|3.279926|3.695705|3.303648|2.831043|19.278261|0.112787|0.114921|0.114338|0.500000| |3.199640|4.127348|7.056413|5.633933|8.942776|17.751863|8.899524|5.644535|4.958375|7.077972|4.724061|4.181931|5.075434|13.909675|4.255868|0.096333|4.034511|0.099297|3.233096|4.475354|3.754323|6.245662|5.855705|2.861754|6.042452|5.489440|6.896724|4.895582|5.132146|10.266339|4.861989|5.049631|4.020366|3.504688|26.054439|0.078575|0.085617|0.085293|0.215304|0.500000| |3.825100|4.086985|5.946916|5.642763|4.962877|5.637178|8.884008|17.731952|8.966398|7.058524|6.725462|4.466921|3.996336|8.405108|3.054356|0.078241|2.735945|0.075173|2.260859|2.980050|2.397748|3.978772|3.842158|2.016467|4.514454|4.023459|4.537016|3.805370|2.885788|4.952201|2.979900|2.921385|2.821862|2.806003|20.549725|0.087322|0.111264|0.111248|0.107746|0.123926|0.500000| |7.227151|6.873063|8.561349|8.870183|5.643525|4.957654|5.652544|8.997628|17.739717|4.142518|3.708204|2.914460|2.809385|5.891038|2.336001|0.059834|2.184034|0.059384|1.875006|2.515952|2.005952|3.425445|3.064061|1.725653|3.845746|3.491412|3.971997|3.123291|2.375137|4.221247|2.481661|2.577728|2.542126|2.428224|16.746882|0.142628|0.217229|0.218641|0.124218|0.107649|0.218516|0.500000| |2.591340|2.782185|4.369484|3.516432|3.537616|4.366454|6.322989|6.244011|4.333958|8.791615|17.812822|8.485130|5.854159|10.464456|4.043058|0.107316|3.410900|0.096763|2.723209|3.477885|2.782547|4.442881|4.691130|2.341028|5.298642|4.628323|5.072380|4.733669|3.322535|5.404680|3.338945|3.015073|2.864954|3.015624|24.281411|0.062806|0.074025|0.074358|0.082842|0.110164|0.219015|0.109469|0.500000| |1.957287|2.123004|3.496903|2.548183|2.718859|3.344093|4.050794|3.550674|2.825368|5.835969|8.461058|17.795198|8.828546|10.471813|6.379664|0.198045|4.769843|0.141322|3.731115|4.546714|3.569594|5.377452|6.376032|2.990241|6.774590|5.872717|6.091035|6.965360|3.934156|6.074966|3.648379|3.018740|2.768888|3.005309|27.211494|0.049098|0.055187|0.055194|0.067645|0.094182|0.105526|0.071763|0.194225|0.500000| |1.549506|1.744571|3.107322|1.959141|2.254903|2.594656|2.474863|2.099551|1.907550|2.778754|2.593812|2.995269|3.699934|6.145910|5.045476|0.128171|5.790264|0.127881|9.041500|26.024587|9.558925|14.115496|8.159747|7.619480|11.294039|16.979985|16.201014|11.285494|5.143588|9.932700|3.772159|3.233296|2.656275|2.582840|22.067880|0.040589|0.042465|0.042225|0.062616|0.083375|0.055494|0.048005|0.063016|0.079002|0.500000| |2.002881|2.285357|3.931010|2.720902|3.184182|4.007047|4.032495|3.200600|2.732637|4.986091|4.450341|5.299653|7.522950|12.461107|8.991937|0.192683|5.780802|0.127257|5.063609|8.137481|9.620938|13.979248|26.063882|3.695930|7.197761|7.297357|7.985397|7.858857|5.177433|9.861525|3.843991|3.285473|2.705939|2.639081|22.600280|0.051018|0.056193|0.054027|0.083498|0.129629|0.084160|0.066846|0.100435|0.126618|0.133985|0.500000| |1.426635|1.569679|2.739541|1.769739|1.968714|2.274353|2.304046|2.002686|1.784786|2.702307|2.715777|3.344811|3.873310|5.761197|5.469180|0.173125|6.044536|0.158071|9.874156|10.869704|5.682951|7.970129|7.022476|7.138576|13.242608|16.913349|11.149723|35.668447|4.270532|6.918410|3.433979|2.812699|2.453308|2.553205|23.100104|0.037183|0.039379|0.039437|0.053136|0.069874|0.054685|0.045580|0.066728|0.094962|0.186840|0.114182|0.500000| |2.352462|2.822557|5.106993|3.264059|4.067847|4.644560|3.908487|3.182831|2.979002|3.843499|3.193635|3.162091|3.762223|7.865858|3.704429|0.086664|4.452498|0.113751|3.678569|4.708546|3.406547|5.482903|4.748993|3.725895|8.157992|6.788029|9.998570|5.289639|6.892586|12.925721|8.947331|17.769285|8.591824|5.739173|37.736622|0.060726|0.061052|0.065285|0.116191|0.155243|0.078478|0.071757|0.077976|0.076859|0.091399|0.092292|0.074507|0.500000| 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