Version2.1 2020-12-26T04:26:03Z 10.1021/jm300687e Gaussian16 RevisionB.01 CFLINN 11-Nov-2020 #N HF/6-31G(d) OPT=(MaxStep=1) FREQ IOp(6/10=2,6/11=2,6/12=2) DUDE CC1(CC2=C([C@H](C(=C(O2)N)c3nc(cs3)c4ccccc4)c5ccc(cc5)OC)C(=O)C1)C C03073419 RHF 6-31G(d) (6D,7F) CC1(CC2=C([C@H](C(=C(O2)N)c3nc(cs3)c4ccccc4)c5ccc(cc5)OC)C(=O)C1)C C01[X(C27H26N2O3S1)] 171 C1 551 COc1ccc(cc1)[C@@H]1C2=C(OC(=C1c1scc(n1)c1ccccc1)N)CC(CC2=O)(C)C COc1ccc(cc1)[C@@H]1C2=C(OC(=C1c1scc(n1)c1ccccc1)N)CC(CC2=O)(C)C COc1ccc(cc1)[C@@H]2C3=C(CC(C)(C)CC3=O)OC(=C2c4scc(n4)c5ccccc5)N InChIKey=OQVFPMXQDOMWMA-JOCHJYFZSA-N InChI=1S/C27H26N2O3S/c1-27(2)13-20(30)23-21(14-27)32-25(28)24(22(23)17-9-11-18(31-3)12-10-17)26-29-19(15-33-26)16-7-5-4-6-8-16/h4-12,15,22H,13-14,28H2,1-3H3/t22-/m1/s1 InChI=1/C27H26N2O3S/c1-27(2)13-20(30)23-21(14-27)32-25(28)24(22(23)17-9-11-18(31-3)12-10-17)26-29-19(15-33-26)16-7-5-4-6-8-16/h4-12,15,22H,13-14,28H2,1-3H3/t22-/m1/s1 CC1(CC2=C([C@H](C(=C(O2)N)c3nc(cs3)c4ccccc4)c5ccc(cc5)OC)C(=O)C1)C C01[X(C27H26N2O3S1)] 171 C01 551 COc1ccc(cc1)[C@@H]1C2=C(OC(=C1c1scc(n1)c1ccccc1)N)CC(CC2=O)(C)C CO[C]1[CH][CH][C]([CH][CH]1)[C@@H]1C2=C(O[C](=C1[C]1SC=[C]([N]1)[C]1[CH][CH][CH][CH][CH]1)[NH2])CC(CC2=O)(C)C CO[C]1[CH][CH][C]([CH][CH]1)[C@H]2C(=C(N)OC3=C2C(=O)CC(C)(C)C3)[C]4[N]C(=CS4)[C]5[CH][CH][CH][CH][CH]5 InChIKey=OQVFPMXQDOMWMA-JOCHJYFZSA-N InChI=1S/C27H26N2O3S/c1-27(2)13-20(30)23-21(14-27)32-25(28)24(22(23)17-9-11-18(31-3)12-10-17)26-29-19(15-33-26)16-7-5-4-6-8-16/h4-12,15,22H,13-14,28H2,1-3H3/t22-/m1/s1 InChI=1/C27H26N2O3S/c1-27(2)13-20(30)23-21(14-27)32-25(28)24(22(23)17-9-11-18(31-3)12-10-17)26-29-19(15-33-26)16-7-5-4-6-8-16/h4-12,15,22H,13-14,28H2,1-3H3/t22-/m1/s1 3464.0911391389 -1768.5754956 1-A 18637.9337 121 430 551 |A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A| -91.96627 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298.150 1.00000 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 6 6 6 6 6 6 1 6 6 8 7 6 7 6 6 16 6 6 6 6 6 6 6 6 6 6 6 6 8 6 6 8 6 6 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 12.00000 12.00000 12.00000 12.00000 12.00000 12.00000 1.00783 12.00000 12.00000 15.99491 14.00307 12.00000 14.00307 12.00000 12.00000 31.97207 12.00000 12.00000 12.00000 12.00000 12.00000 12.00000 12.00000 12.00000 12.00000 12.00000 12.00000 12.00000 15.99491 12.00000 12.00000 15.99491 12.00000 12.00000 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783
10669.6749 24804.3802 31135.4391 0.99994 -0.01102 -0.00267 0.01101 0.99992 -0.00564 0.00273 0.00561 0.99998 1 0.00812 0.00349 0.00278 0.16915 0.07276 0.05796 23.49 37.66 41.58 54.73 63.75 73.77 88.75 107.50 127.68 138.53 157.27 176.32 194.12 240.20 268.10 279.02 314.96 328.59 348.54 360.06 390.93 403.70 433.96 445.51 458.88 471.57 487.07 493.67 525.56 535.44 559.10 585.03 613.52 644.80 656.18 657.74 670.33 680.62 737.94 750.66 783.66 800.18 818.32 857.78 866.59 898.79 926.73 939.78 965.67 977.32 981.33 996.22 1028.49 1051.42 1070.71 1101.47 1116.11 1142.31 1152.86 1205.82 1214.46 1234.33 1250.69 1260.90 1268.35 1316.49 1328.56 1333.12 1366.66 1378.57 1392.90 1430.45 1446.08 1480.04 1491.19 1506.42 1514.89 1537.05 1556.16 1567.55 1580.57 1587.02 1597.28 1616.34 1617.87 1625.12 1644.78 1669.05 1705.05 1706.45 1713.63 1732.63 1749.40 1760.50 1810.74 1817.57 1847.30 1862.47 1863.45 1873.53 1878.55 1885.87 1904.00 1912.20 1925.34 1932.00 1966.15 1986.05 2029.83 2038.66 2043.82 2074.38 2074.78 2085.02 2111.87 2139.05 2142.27 2159.52 2210.73 2229.72 2246.24 2273.01 2284.76 2316.09 2318.10 2337.31 2347.36 2352.45 2362.74 2375.38 2376.53 2378.70 2387.46 2390.47 2402.38 2440.32 2489.56 2531.85 2557.10 2567.54 2609.88 2619.24 2633.08 2738.26 2842.56 4591.28 4595.08 4603.12 4611.22 4617.17 4655.11 4672.67 4689.21 4696.60 4698.76 4702.36 4715.23 4725.28 4781.01 4826.69 4840.85 4846.88 4858.89 4865.72 4873.30 4889.09 4890.35 4893.51 4975.77 5455.11 5655.59 0.512545 0.540014 0.540958 0.452409 -1768.062950 -1768.035482 -1768.034538 -1768.123087 2.969948D-04
MUNgauss RevisionA2.0 retrievium 26-Dec-2020 DUDE CC1(CC2=C([C@H](C(=C(O2)N)c3nc(cs3)c4ccccc4)c5ccc(cc5)OC)C(=O)C1)C C03073419 RHF 6-31G(d) (6D,10F) C1 458.166415 |X|Y|Z| 69.543172 111.548208 36.859950
65.880560 27 6 7 8 16 24 1 1 1
|36.858105| |12.425339|36.858105| |7.601516|12.379942|36.858105| |4.956972|7.529444|12.707326|36.858105| |4.348756|6.496985|7.553520|14.380766|36.858105| |3.234179|4.309417|4.876492|7.686906|12.582531|36.858105| |3.006714|3.862115|4.171857|5.886865|9.070348|17.570384|0.500000| |2.902933|3.673871|4.494961|6.901028|7.710344|12.517071|0.247773|36.858105| |3.119336|3.916299|5.255584|8.129570|6.940857|7.659249|0.161869|14.121937|36.858105| |3.914117|5.144107|8.065283|14.061453|8.130314|6.712259|0.142574|8.052120|14.074915|73.516695| |2.719313|3.227573|4.224097|5.485377|4.678888|5.037225|0.117606|7.843594|14.114512|15.345051|53.358707| |2.386510|2.879546|3.360614|4.530239|4.995675|7.387685|0.193134|13.053981|7.819238|9.165999|8.843469|36.858105| |2.157155|2.526955|2.966837|3.781313|3.894919|5.017373|0.132397|7.784362|6.582657|7.978598|9.353856|14.762066|53.358707| |1.887141|2.169652|2.464435|3.014721|3.164810|3.987189|0.111171|5.246233|4.475408|6.042550|6.307410|8.570726|18.807258|36.858105| 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|6.652799|8.756317|17.550195|9.041026|5.790521|4.216966|0.099412|4.091666|4.990632|13.740789|5.792361|3.135218|3.865562|2.362846|2.237744|18.368811|2.101804|1.843221|1.678354|1.693906|1.887321|2.131480|3.692563|3.051298|2.680230|2.695048|3.104890|3.728826|4.126302|2.218049|4.925981|6.700266|5.540621|7.121623|0.197059|0.137958|0.162024|0.500000| |7.252372|8.768688|17.500274|9.035484|6.153214|4.298340|0.106970|4.150937|4.882904|12.368824|5.589675|3.212409|3.943421|2.420590|2.303761|18.966521|2.145172|1.864912|1.696696|1.720436|1.932035|2.192240|3.476069|2.946930|2.522080|2.439300|2.711636|3.266571|3.744199|1.977297|5.548342|7.385528|6.672521|5.504331|0.182522|0.144617|0.217092|0.304018|0.500000| |2.407018|2.809227|3.513066|4.435479|4.052832|4.602086|0.112322|7.215190|9.509851|10.864383|25.993898|7.318000|12.706219|5.803360|4.396676|31.468707|4.992620|3.736790|3.197143|3.282247|4.039980|5.339311|3.839332|3.057297|2.647661|2.671522|3.142355|3.906550|4.056945|2.190086|3.103569|4.984179|2.727717|2.630406|0.065782|0.059717|0.066771|0.097006|0.096072|0.500000| |2.807254|3.252379|4.363932|5.253226|4.253583|4.251126|0.101654|5.857753|9.512543|14.591897|26.070204|4.928822|7.103399|3.847731|3.217851|24.162165|3.479500|2.812685|2.524162|2.635069|3.159619|3.789223|3.526789|2.817550|2.458054|2.496133|2.945619|3.634704|3.820039|2.080292|3.250572|5.011811|2.996647|2.974098|0.078255|0.067805|0.078117|0.125824|0.121712|0.309153|0.500000| |1.693017|1.929557|2.100489|2.505767|2.737813|3.433859|0.102018|3.887283|3.229116|4.715574|4.268816|5.458692|7.800002|8.754458|17.818198|55.116960|6.563645|6.391752|4.461316|3.648420|3.677723|4.555928|3.266213|3.127201|2.801195|2.626514|2.704623|3.000747|4.139122|2.135857|2.421338|4.418112|2.053986|1.864865|0.044901|0.044436|0.046990|0.055410|0.057088|0.098809|0.075967|0.500000| |1.496107|1.675258|1.839428|2.135245|2.226116|2.648459|0.074340|3.078971|2.792569|4.144531|3.975787|3.995444|6.501192|7.029410|6.796367|30.503369|8.904046|17.722749|8.942795|5.651235|4.962240|5.651568|2.579862|2.419219|2.262683|2.236622|2.360043|2.541593|3.630892|1.954486|1.964649|3.495383|1.726393|1.636975|0.040387|0.039206|0.041440|0.049807|0.050146|0.094194|0.072226|0.213705|0.500000| |1.305724|1.431229|1.567890|1.764093|1.794246|2.036145|0.056667|2.330460|2.227603|3.427383|3.265476|2.795164|4.489361|4.112341|3.750910|20.016977|5.630991|8.934218|17.713684|8.910782|5.651670|4.959000|1.973549|1.858052|1.763545|1.763752|1.860312|1.973158|2.925728|1.607151|1.609883|2.839699|1.456023|1.395858|0.035576|0.034287|0.036353|0.042938|0.043240|0.076038|0.061789|0.111251|0.216302|0.500000| |1.313226|1.422645|1.578849|1.750362|1.737204|1.916986|0.052828|2.226278|2.217079|3.449106|3.368295|2.580773|4.220896|3.561485|3.056575|17.316393|4.925783|5.642696|8.905931|17.715372|8.903918|5.641182|1.813542|1.679976|1.579138|1.583434|1.692227|1.818724|2.615806|1.444977|1.554022|2.698884|1.430140|1.371456|0.036024|0.034258|0.036851|0.043541|0.044157|0.078702|0.065634|0.085083|0.124256|0.214563|0.500000| |1.522543|1.652430|1.880801|2.094462|2.034389|2.220080|0.060558|2.676979|2.763145|4.237464|4.404719|3.073258|5.252487|4.119511|3.285260|19.142506|5.632035|4.961007|5.652394|8.912788|17.711478|8.934104|2.027391|1.830585|1.684407|1.683124|1.830076|2.023050|2.732322|1.501179|1.785661|3.046446|1.648619|1.565394|0.041830|0.039204|0.043066|0.051893|0.053328|0.106141|0.087332|0.085935|0.107674|0.124146|0.214617|0.500000| |1.852081|2.065933|2.414938|2.817894|2.745787|3.099505|0.083972|4.054412|4.161472|5.891480|6.881174|4.974378|9.869710|7.086077|4.823484|27.708508|8.926702|5.657809|4.961321|5.646002|8.925699|17.743972|2.704578|2.360822|2.102979|2.078380|2.298090|2.649960|3.278874|1.771428|2.315160|3.908559|2.078464|1.931366|0.050342|0.047119|0.052370|0.065614|0.068296|0.186664|0.127856|0.114637|0.124255|0.107661|0.124132|0.215647|0.500000| |2.643156|3.298266|3.217402|3.981825|5.414547|6.975869|0.224785|4.708464|3.680257|6.204427|4.043978|4.273871|4.528493|3.057560|3.452117|35.476273|2.471550|2.254141|1.938122|1.814865|1.921290|2.227654|8.909487|17.736122|8.985489|5.654408|4.964221|5.681792|7.618884|3.336650|5.526457|12.395841|3.901701|3.360607|0.066693|0.071285|0.069895|0.080100|0.080681|0.079804|0.073712|0.087452|0.065524|0.050511|0.045731|0.049821|0.064098|0.500000| |2.200761|2.630679|2.523898|2.922308|3.509003|4.066399|0.113902|3.268876|2.782510|4.777939|3.255414|3.106113|3.560976|2.488516|2.768223|25.106039|2.105076|1.994701|1.746131|1.621973|1.678748|1.895837|5.611875|8.901147|17.733901|8.958016|5.666586|4.978124|13.473103|4.872095|3.550162|7.154609|2.885757|2.873117|0.057180|0.060632|0.057244|0.066028|0.063124|0.064713|0.060319|0.072854|0.058878|0.046411|0.041360|0.043581|0.053421|0.215453|0.500000| |2.326850|2.809288|2.922623|3.425556|3.614530|4.070519|0.096717|3.808054|3.584845|6.200942|4.351375|3.444127|4.144074|2.724355|2.751391|23.055349|2.356595|2.194609|1.935132|1.826891|1.916920|2.167850|5.631640|4.966073|5.637636|8.868812|17.756786|8.948722|12.460888|7.446331|3.144895|5.386010|2.709777|3.234176|0.063687|0.061587|0.059315|0.082676|0.070656|0.083988|0.079747|0.069262|0.063149|0.050803|0.046483|0.050017|0.061609|0.107773|0.124189|0.500000| |2.850336|3.639670|4.150891|5.570627|5.748714|6.913334|0.141095|6.898791|6.559371|10.853384|7.065671|5.291668|5.944097|3.528799|3.421565|30.294138|2.909044|2.557726|2.208532|2.116942|2.303031|2.707417|8.925473|5.671339|4.976995|5.667706|8.981217|17.716394|7.465253|3.924466|4.247681|6.791652|3.470162|3.949469|0.077187|0.072423|0.073279|0.115818|0.097587|0.128188|0.121484|0.081530|0.071684|0.056389|0.052969|0.060102|0.079756|0.124388|0.107957|0.218774|0.500000| |2.044613|2.372081|2.340223|2.573417|2.720464|2.899070|0.073265|2.651499|2.519284|4.487998|3.130358|2.466803|3.041541|2.080815|2.138321|17.401622|1.855885|1.774980|1.600990|1.513192|1.562115|1.722256|3.721803|3.792495|4.759083|7.031942|6.732336|4.575233|16.441528|17.552930|2.568464|4.539679|2.310194|2.786231|0.056118|0.055797|0.051923|0.066027|0.057578|0.061127|0.059342|0.055746|0.051379|0.042789|0.039106|0.041094|0.048489|0.088240|0.119778|0.224165|0.113343|0.500000| |1.846862|2.136810|2.164331|2.436937|2.594298|2.902038|0.074160|2.740400|2.551098|4.362869|3.218265|2.661410|3.314600|2.314063|2.401481|19.223184|2.061692|2.000436|1.788935|1.663924|1.698503|1.876075|3.730940|3.802402|4.772401|7.047212|6.737827|4.583982|16.443577|17.555202|2.395172|4.275536|2.114756|2.405442|0.050496|0.049944|0.047726|0.060622|0.054096|0.064290|0.060070|0.063003|0.058813|0.048048|0.042805|0.044170|0.052059|0.088389|0.120093|0.223839|0.113600|0.299048|0.500000| |1.768356|2.016760|1.983247|2.176667|2.332114|2.528563|0.066103|2.325975|2.172093|3.795769|2.727698|2.241767|2.788849|1.963017|2.055855|16.475040|1.764263|1.719787|1.555828|1.455133|1.481499|1.620783|3.171384|3.413582|4.414926|5.880588|4.904433|3.618211|17.007540|17.640146|2.242364|4.069748|2.014411|2.292697|0.048189|0.048635|0.045556|0.055203|0.049775|0.054273|0.051699|0.054704|0.050444|0.042050|0.037736|0.038801|0.045080|0.082233|0.121221|0.145696|0.089226|0.300030|0.299978|0.500000| |7.113520|8.816984|6.877263|5.996491|6.317258|4.364444|0.120308|3.637229|3.633524|7.652232|4.070815|2.945260|3.481889|2.232592|2.237407|19.128183|1.948714|1.729016|1.563296|1.554425|1.707037|1.929852|3.596954|3.323271|2.786144|2.539734|2.653033|3.110893|3.904758|1.991226|9.066951|12.022149|17.486693|5.499067|0.143499|0.175321|0.214539|0.139225|0.195689|0.074821|0.082531|0.056511|0.047422|0.040302|0.039957|0.046454|0.058525|0.097098|0.071603|0.066814|0.085466|0.057180|0.053299|0.050685|0.500000| |6.771455|8.732481|5.518900|4.978736|5.579413|4.070780|0.110901|3.245624|3.163255|6.540068|3.573381|2.670883|3.143938|2.047631|2.083979|17.947378|1.789487|1.614112|1.460237|1.437518|1.556224|1.746680|3.717638|3.610960|3.110504|2.812009|2.860585|3.242022|4.348504|2.191208|9.005235|13.488508|17.583756|6.960335|0.138893|0.200621|0.167216|0.123152|0.137454|0.066236|0.071427|0.053168|0.044801|0.037979|0.037071|0.042106|0.052090|0.104879|0.080792|0.071503|0.086100|0.063488|0.057397|0.055891|0.303259|0.500000| |6.991704|8.767091|6.832271|5.272387|4.583271|3.543323|0.086107|3.147743|3.407917|7.723393|4.011478|2.543486|3.104930|1.978516|1.936338|16.026986|1.766252|1.594622|1.457471|1.448503|1.572921|1.749445|3.513395|3.108696|2.876108|2.935219|3.271368|3.624996|4.595816|2.475627|4.627723|6.686103|5.485596|17.541354|0.209556|0.173574|0.141613|0.211817|0.143239|0.071466|0.082635|0.048947|0.043901|0.037882|0.037519|0.042889|0.052275|0.080684|0.071770|0.087624|0.104690|0.076047|0.065251|0.061910|0.123065|0.141404|0.500000| |5.498153|8.682299|6.825159|6.600206|6.536707|4.825348|0.113324|3.895375|3.983426|8.810331|4.407974|3.040136|3.562971|2.252910|2.243826|19.360781|1.958642|1.761143|1.584083|1.554265|1.684227|1.901853|5.006181|4.336758|3.873037|3.861416|4.318742|4.994614|5.732192|2.957138|6.693449|9.314382|6.800173|17.573496|0.141158|0.141307|0.122248|0.178872|0.137932|0.078828|0.086962|0.056254|0.048942|0.041095|0.039910|0.045342|0.056631|0.109642|0.093391|0.109061|0.136471|0.090148|0.076955|0.072309|0.138359|0.171817|0.301805|0.500000| |6.948336|8.779900|5.482376|4.630664|4.591582|3.544147|0.089629|2.968436|3.028362|6.478629|3.511009|2.439736|2.930820|1.900504|1.903072|16.019167|1.684088|1.531769|1.395469|1.375540|1.481954|1.648340|3.569997|3.360208|3.108307|3.034862|3.189723|3.465546|4.771896|2.486631|5.418118|8.117023|6.896504|17.550077|0.170670|0.209448|0.141461|0.142961|0.123069|0.064136|0.070861|0.048540|0.042538|0.036443|0.035633|0.040191|0.048870|0.089734|0.079242|0.082558|0.094037|0.075274|0.064164|0.062904|0.142195|0.209012|0.301779|0.302064|0.500000|
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