Version2.2 2021-02-19T13:33:32Z 10.1021/jm300687e Gaussian16 RevisionB.01 SBUNGAY 04-Nov-2020 #N HF/6-31G(d) OPT=(MaxStep=1) FREQ IOp(6/10=2,6/11=2,6/12=2) DUDE CCOC(=O)[C@@]1([C@H]2C=CC(=CN2[C@@H]([C@@H]1c3cccc(c3)Cl)C(=O)N)C(=O)N)C#N C04614352 RHF 6-31G(d) (6D,7F) CCOC(=O)[C@@]1([C@H]2C=CC(=CN2[C@@H]([C@@H]1c3cccc(c3)Cl)C(=O)N)C(=O)N)C#N C01[X(C20H19Cl1N4O4)] 138 C1 477 CCOC(=O)[C@]1(C#N)[C@H]2C=CC(=CN2[C@@H]([C@@H]1c1cccc(c1)Cl)C(=O)N)C(=O)N CCOC(=O)[C@]1(C#N)[C@H]2C=CC(=CN2[C@@H]([C@@H]1c1cccc(c1)Cl)C(=O)N)C(=O)N CCOC(=O)[C@]1(C#N)[C@H]2C=CC(=CN2[C@@H]([C@@H]1c3cccc(Cl)c3)C(N)=O)C(N)=O InChIKey=FYRLJUJGNGSBEC-NARAOEGZSA-N InChI=1S/C20H19ClN4O4/c1-2-29-19(28)20(10-22)14-7-6-12(17(23)26)9-25(14)16(18(24)27)15(20)11-4-3-5-13(21)8-11/h3-9,14-16H,2H2,1H3,(H2,23,26)(H2,24,27)/t14-,15+,16+,20-/m1/s1 InChI=1/C20H19ClN4O4/c1-2-29-19(28)20(10-22)14-7-6-12(17(23)26)9-25(14)16(18(24)27)15(20)11-4-3-5-13(21)8-11/h3-9,14-16H,2H2,1H3,(H2,23,26)(H2,24,27)/t14-,15+,16+,20-/m1/s1/f/h23-24H2 CCOC(=O)[C@@]1([C@H]2C=CC(=CN2[C@@H]([C@@H]1c3cccc(c3)Cl)C(=O)N)C(=O)N)C#N C01[X(C20H19Cl1N4O4)] 138 C01 477 CCOC(=O)[C@]1(C#N)[C@H]2C=CC(=CN2[C@@H]([C@@H]1c1cccc(c1)Cl)C(=O)N)C(=O)N CCOC(=O)[C@]1(C#N)[C@H]2C=CC(=CN2[C@@H]([C@@H]1[C]1[CH][CH][CH][C]([CH]1)Cl)C(=O)N)C(=O)N CCOC(=O)[C@]1(C#N)[C@H]2C=CC(=CN2[C@@H]([C@@H]1[C]3[CH][CH][CH][C](Cl)[CH]3)C(N)=O)C(N)=O InChIKey=FYRLJUJGNGSBEC-NARAOEGZSA-N InChI=1S/C20H19ClN4O4/c1-2-29-19(28)20(10-22)14-7-6-12(17(23)26)9-25(14)16(18(24)27)15(20)11-4-3-5-13(21)8-11/h3-9,14-16H,2H2,1H3,(H2,23,26)(H2,24,27)/t14-,15+,16+,20-/m1/s1 InChI=1/C20H19ClN4O4/c1-2-29-19(28)20(10-22)14-7-6-12(17(23)26)9-25(14)16(18(24)27)15(20)11-4-3-5-13(21)8-11/h3-9,14-16H,2H2,1H3,(H2,23,26)(H2,24,27)/t14-,15+,16+,20-/m1/s1/f/h23-24H2 2981.6713876643 -1745.1615679 1-A 12517.4405 108 369 477 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298.150 1.00000 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 6 6 8 6 8 6 6 1 6 6 6 6 7 6 1 6 1 6 6 6 6 6 6 17 6 8 7 6 8 7 6 7 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 12.00000 12.00000 15.99491 12.00000 15.99491 12.00000 12.00000 1.00783 12.00000 12.00000 12.00000 12.00000 14.00307 12.00000 1.00783 12.00000 1.00783 12.00000 12.00000 12.00000 12.00000 12.00000 12.00000 34.96885 12.00000 15.99491 14.00307 12.00000 15.99491 14.00307 12.00000 14.00307 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783
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MUNgauss RevisionA2.1 retrievium 19-Feb-2021 DUDE CCOC(=O)[C@@]1([C@H]2C=CC(=CN2[C@@H]([C@@H]1c3cccc(c3)Cl)C(=O)N)C(=O)N)C#N C04614352 RHF 6-31G(d) (6D,10F) C1 414.109483 |X|Y|Z| 63.198049 84.874400 36.328099
57.975035 15 6 7 14 1
|36.858105| |12.594752|36.858105| |8.028339|13.284598|73.516695| |5.282042|8.096057|25.833550|36.858105| |4.592047|7.112259|15.290465|16.064798|73.516695| |4.062044|5.149552|14.422807|12.434434|14.089974|36.858105| |3.784681|4.499909|11.359410|7.625352|10.275260|11.970482|36.858105| |4.264293|5.203232|12.700881|8.032896|11.151694|8.777751|17.523276|0.500000| |3.511282|3.800767|9.045060|5.188131|7.282626|7.168896|12.643565|0.247855|36.858105| |2.889081|3.065175|6.761991|3.917119|5.905432|5.017363|7.787581|0.177962|14.355065|36.858105| |2.545846|2.766324|5.909224|3.585678|5.693608|4.470108|6.711167|0.161161|7.808681|13.013004|36.858105| |2.591028|2.927808|6.312487|4.076908|6.634059|5.206234|7.801021|0.181260|6.844610|7.953051|14.133525|36.858105| |2.997335|3.534314|8.044634|5.616544|8.847981|7.999311|13.128765|0.254538|7.872338|7.000160|8.102045|14.156745|53.358707| 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|1.813561|2.082860|4.070696|2.686535|5.103046|2.875533|2.510603|0.064816|2.199021|2.067839|2.159177|2.493146|3.778533|3.428721|0.104753|3.675875|0.100258|4.754711|4.239588|4.784407|7.040369|10.937187|7.056693|448.794386| |2.921899|3.673942|7.607274|5.761281|11.705683|5.919030|6.063496|0.171984|4.165817|3.757173|4.190650|5.740241|10.563688|12.341501|0.248453|7.112776|0.151265|5.682562|4.397587|3.549861|3.388433|3.884343|5.077845|25.806787|36.858105| |3.049458|3.798750|7.618293|5.378649|10.578671|5.203339|6.009018|0.192756|4.222839|3.877054|4.370753|5.774160|9.685865|7.999731|0.174626|5.355659|0.121958|4.313975|3.608384|2.988872|2.827978|3.131448|3.861316|21.521900|15.934385|73.516695| |2.636198|3.296123|6.499527|4.782796|10.467943|4.661639|4.361655|0.122276|3.270816|2.991564|3.275866|4.204845|7.036146|7.728707|0.196976|5.838639|0.128294|5.735329|4.534023|3.857452|3.831100|4.479221|5.641869|29.917369|14.060618|15.097863|53.358707| |2.162116|2.304158|4.726334|2.818288|4.616609|3.326249|4.426258|0.113825|4.999172|7.298741|12.903971|7.880326|7.051986|3.895731|0.107978|3.287834|0.096715|2.631171|2.279335|1.980753|1.920649|2.118398|2.496910|15.665684|3.381044|6.315734|3.789830|36.858105| |1.963236|2.109377|4.261414|2.578500|4.331564|2.993874|3.786732|0.098534|3.976271|5.161572|8.087443|6.898680|6.314768|3.751127|0.108839|3.089302|0.090447|2.536253|2.180839|1.920432|1.892916|2.112288|2.475892|15.946730|3.324015|6.145387|3.809105|15.814863|73.516695| |2.079787|2.157612|4.362310|2.519875|4.103134|2.905345|3.743286|0.098513|4.479314|6.475625|7.879493|5.247655|5.441115|3.131977|0.085571|2.784877|0.081722|2.288065|2.036230|1.788255|1.724845|1.870843|2.160836|13.884166|2.789769|5.237416|3.206361|13.924925|15.116650|53.358707| |4.015741|4.653299|12.506677|7.759155|9.743393|12.918278|7.449503|0.162883|6.620492|4.662327|3.883019|4.146130|7.429918|5.152917|0.118478|7.658732|0.210843|5.827215|5.706994|4.124678|3.404474|3.439808|4.203224|21.469888|4.084964|6.605594|4.759859|3.002235|4.766935|3.711063|36.858105| |3.729311|4.040134|9.859708|5.534569|7.595761|7.302663|5.355530|0.124277|5.430539|4.102950|3.384464|3.475301|5.775780|4.015733|0.097633|5.514163|0.162467|4.741314|4.918204|3.823626|3.174781|3.135244|3.655840|19.995700|3.295737|5.410891|3.978298|2.718736|4.329001|3.450359|16.794349|53.358707| |17.561143|8.916163|10.203742|4.278212|7.069003|3.362900|3.172223|0.098915|2.953091|2.512127|2.262196|2.304990|3.562957|2.535162|0.061583|2.711661|0.068384|2.547627|2.739412|2.419931|2.085899|1.998155|2.163276|13.643304|2.641203|4.927243|3.313952|1.960665|3.199056|2.579070|3.293927|4.221691|0.500000| |17.581714|8.856864|12.887909|4.910026|7.436329|3.980717|3.584199|0.106935|3.425866|2.807765|2.441281|2.467627|3.877990|2.728047|0.065889|3.063562|0.078283|2.850177|3.121139|2.695416|2.271815|2.162507|2.360611|14.519254|2.705600|4.900457|3.354939|2.078550|3.352997|2.736232|4.224860|5.587848|0.300582|0.500000| |17.579912|8.856957|12.859225|4.912717|7.439285|4.010217|4.006305|0.128339|3.856702|3.176951|2.749216|2.736901|4.240473|2.870130|0.068634|3.050156|0.077629|2.714973|2.820763|2.415681|2.094059|2.050660|2.277806|13.972127|2.907315|5.511506|3.493328|2.329253|3.711436|3.082901|3.936865|4.961019|0.300772|0.300784|0.500000| |8.804623|17.628104|16.515857|7.250766|12.762513|4.695793|3.890458|0.119166|3.291397|2.709045|2.487665|2.663180|4.363118|3.303547|0.077954|3.725754|0.088816|3.632682|4.127216|3.489008|2.850067|2.673062|2.922776|17.393328|3.494752|6.214873|4.462334|2.099971|3.463817|2.669631|4.345173|5.249075|0.211583|0.211064|0.172953|0.500000| |8.797121|17.631452|16.519280|7.283066|12.805824|4.755898|4.456549|0.151533|3.673229|3.039317|2.818499|3.014417|4.906720|3.570497|0.082715|3.708509|0.088011|3.370009|3.503918|2.941731|2.523430|2.472735|2.773417|16.489622|3.969518|7.635200|4.808004|2.361063|3.865684|2.990251|4.042876|4.728818|0.211110|0.172889|0.211219|0.301910|0.500000| |3.828390|3.962944|9.519700|5.022571|6.902599|6.546069|8.533333|0.193565|17.749803|9.066290|5.558768|4.949779|7.675739|4.269988|0.101457|4.663543|0.134547|3.523862|3.274923|2.659492|2.369892|2.462596|2.924133|16.695520|3.547025|6.347048|3.951737|4.047615|5.888655|5.246649|7.222351|8.686809|0.087750|0.107002|0.118040|0.094806|0.102390|0.500000| |2.683916|2.755721|5.910129|3.318209|5.065209|4.075172|5.553418|0.135049|9.181299|17.715313|8.673530|5.688410|6.859591|3.689054|0.094788|3.562662|0.106924|2.791810|2.511178|2.135513|1.994621|2.128796|2.499668|15.154499|3.099820|5.675419|3.485145|6.676831|8.426836|9.640713|4.045574|5.127463|0.065438|0.073417|0.082454|0.068150|0.075265|0.219019|0.500000| |2.314037|2.614192|5.456951|3.537146|6.014268|4.291286|5.626769|0.140159|4.942722|5.623573|9.024210|17.755997|12.519775|7.063724|0.212631|4.787636|0.135946|3.640091|2.934560|2.494357|2.454048|2.825714|3.522371|20.601133|5.688498|10.016130|5.907154|7.285024|13.778308|6.535938|3.488052|4.070872|0.058123|0.061200|0.067173|0.067209|0.075435|0.107630|0.124307|0.500000| |3.623757|4.592515|10.090095|7.268443|12.472870|6.849062|4.366979|0.112042|3.568716|2.926506|2.739854|3.081889|5.334130|4.559552|0.109380|6.752701|0.155203|8.872675|17.791395|9.014806|5.665109|4.984671|5.652511|27.488377|4.137936|6.300932|5.538846|2.271329|3.806228|2.794845|6.829219|7.947585|0.088066|0.104230|0.090536|0.141170|0.111940|0.099728|0.072418|0.078439|0.500000| |2.650947|3.127186|6.028355|3.888298|7.346500|3.721637|2.853884|0.075157|2.479993|2.167501|2.091823|2.322376|3.743769|3.203932|0.083712|4.052336|0.102510|5.638862|8.944288|17.728348|8.951554|5.688097|4.977004|31.640464|3.063863|4.738169|4.472723|1.817457|3.121583|2.262077|3.761897|4.909650|0.068359|0.076355|0.066583|0.098369|0.079810|0.069050|0.055198|0.061627|0.218827|0.500000| |2.043776|2.360782|4.530743|2.944309|5.639959|2.977611|2.449974|0.064158|2.149377|1.953486|1.954016|2.197124|3.428025|3.010318|0.084018|3.527391|0.092693|4.908025|5.624982|8.881475|17.754027|8.916465|5.637628|53.694602|2.887728|4.394555|4.441856|1.738506|3.059410|2.144109|2.891865|3.749779|0.053416|0.057617|0.052972|0.071065|0.062913|0.058316|0.049899|0.060328|0.124511|0.214359|0.500000| |2.219732|2.618020|5.421780|3.816877|7.098905|4.498679|3.869434|0.095106|3.186911|2.953577|3.159812|3.927184|6.353737|6.700803|0.228932|7.100837|0.192479|8.848703|5.652129|4.978715|5.658551|8.999712|17.738253|54.542799|5.327735|7.131104|7.912761|2.712133|4.868861|3.136750|3.843959|4.559633|0.056276|0.060820|0.060017|0.073364|0.072050|0.080265|0.071884|0.111989|0.123689|0.107978|0.124630|0.500000| |2.581260|3.222646|6.404191|4.760674|10.437451|4.714236|4.103799|0.111140|3.134004|2.836773|3.038812|3.821389|6.444609|7.202034|0.190901|6.327818|0.137484|7.205851|5.482601|4.693105|4.769730|5.790757|7.498872|36.226395|9.336415|10.929358|26.065615|2.588596|4.608808|3.012370|3.626821|4.150918|0.066136|0.068144|0.068891|0.091237|0.093138|0.078612|0.068123|0.108135|0.128708|0.106822|0.109155|0.201966|0.500000| |2.613284|3.269361|6.163336|4.365258|9.829967|4.006566|3.812144|0.111137|2.940897|2.706176|2.937319|3.634541|5.840155|5.680522|0.145332|4.612432|0.104699|4.620827|3.963771|3.497695|3.458295|3.867828|4.519496|26.708418|9.583521|13.913373|25.996967|2.548833|4.559452|2.983786|3.102325|3.590165|0.068149|0.067093|0.070369|0.091029|0.099792|0.073580|0.065214|0.104045|0.101650|0.085308|0.084137|0.126154|0.314601|0.500000| |2.229733|2.280927|4.609516|2.607612|4.195383|2.975376|3.882952|0.104033|4.856285|7.091751|7.311588|4.873332|5.328464|3.042064|0.081087|2.756674|0.080055|2.260700|2.037630|1.782541|1.701352|1.825634|2.102405|13.417999|2.738153|5.199925|3.135210|9.291467|10.951147|26.073610|2.818604|3.578135|0.056198|0.059754|0.068445|0.056981|0.064399|0.118216|0.233545|0.119070|0.057782|0.046290|0.043163|0.061434|0.060130|0.059913|0.500000| |1.893757|1.956993|3.890000|2.244601|3.707794|2.537741|3.160821|0.084514|3.633318|4.839500|5.777242|4.332765|4.620183|2.771276|0.076761|2.466161|0.071925|2.072497|1.855890|1.649953|1.603231|1.737272|1.983068|13.064246|2.523603|4.741437|2.955867|9.534399|14.050746|26.017176|2.389234|3.048902|0.048438|0.050836|0.057005|0.049786|0.055562|0.089219|0.144889|0.116236|0.051767|0.042744|0.040950|0.058846|0.056701|0.056630|0.314413|0.500000|
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