Version2.1 2021-01-10T09:08:27Z 10.1021/jm300687e Gaussian16 RevisionB.01 PWARBURT 30-Dec-2020 #N HF/6-31G(d) OPT=(MaxStep=1) FREQ IOp(6/10=2,6/11=2,6/12=2) DUDE CCOC(=O)C1=C(C(=N[C@@H]1C)C(=O)COC(=O)CSc2nnc(o2)c3ccc(cc3)Cl)C C39617585 RHF 6-31G(d) (6D,7F) CCOC(=O)C1=C(C(=N[C@@H]1C)C(=O)COC(=O)CSc2nnc(o2)c3ccc(cc3)Cl)C C01[X(C21H20Cl1N3O6S1)] 150 C1 528 CCOC(=O)C1=C(C)C(=N[C@@H]1C)C(=O)COC(=O)CSc1nnc(o1)c1ccc(cc1)Cl CCOC(=O)C1=C(C)C(=N[C@@H]1C)C(=O)COC(=O)CSc1nnc(o1)c1ccc(cc1)Cl CCOC(=O)C1=C(C)C(=N[C@@H]1C)C(=O)COC(=O)CSc2oc(nn2)c3ccc(Cl)cc3 InChIKey=ZVNDJTOESSDROH-GFCCVEGCSA-N InChI=1S/C21H20ClN3O6S/c1-4-29-20(28)17-11(2)18(23-12(17)3)15(26)9-30-16(27)10-32-21-25-24-19(31-21)13-5-7-14(22)8-6-13/h5-8,12H,4,9-10H2,1-3H3/t12-/m1/s1 InChI=1/C21H20ClN3O6S/c1-4-29-20(28)17-11(2)18(23-12(17)3)15(26)9-30-16(27)10-32-21-25-24-19(31-21)13-5-7-14(22)8-6-13/h5-8,12H,4,9-10H2,1-3H3/t12-/m1/s1 CCOC(=O)C1=C(C(=N[C@@H]1C)C(=O)COC(=O)CSc2nnc(o2)c3ccc(cc3)Cl)C C01[X(C21H20Cl1N3O6S1)] 150 C01 528 CCOC(=O)C1=C(C)C(=N[C@@H]1C)C(=O)COC(=O)CSc1nnc(o1)c1ccc(cc1)Cl CCOC(=O)C1=C(C)C(=N[C@@H]1C)C(=O)COC(=O)CSc1nnc(o1)[C]1[CH][CH][C]([CH][CH]1)Cl CCOC(=O)C1=C(C)C(=N[C@@H]1C)C(=O)COC(=O)CSc2oc(nn2)[C]3[CH][CH][C](Cl)[CH][CH]3 InChIKey=ZVNDJTOESSDROH-GFCCVEGCSA-N InChI=1S/C21H20ClN3O6S/c1-4-29-20(28)17-11(2)18(23-12(17)3)15(26)9-30-16(27)10-32-21-25-24-19(31-21)13-5-7-14(22)8-6-13/h5-8,12H,4,9-10H2,1-3H3/t12-/m1/s1 InChI=1/C21H20ClN3O6S/c1-4-29-20(28)17-11(2)18(23-12(17)3)15(26)9-30-16(27)10-32-21-25-24-19(31-21)13-5-7-14(22)8-6-13/h5-8,12H,4,9-10H2,1-3H3/t12-/m1/s1 3067.5660722825 -2276.3907153 1-A 45992.9339 124 404 528 |A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A| -104.83594 -91.98536 -20.67442 -20.63138 -20.61948 -20.58910 -20.57470 -20.55921 -15.60227 -15.60136 -15.59539 -11.40649 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-0.37388 -0.37113 -0.36415 -0.32176 |A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A| 0.05776 0.07966 0.11887 0.11911 0.16738 0.17134 0.18194 0.19051 0.22011 0.23342 0.23513 0.23718 0.24248 0.24970 0.25573 0.26754 0.26859 0.27148 0.28020 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10.32718
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225.2366 252.1615 264.4737 281.1958 283.2770 288.1745 303.0355 314.2870 337.2338 351.3299 363.1544 387.9056 408.0845 413.6011 440.5000 455.6364 495.0709 511.6826 525.8925 545.3096 568.8564 591.6103 596.7293 607.4068 632.7741 639.4814 692.6212 711.6342 751.9370 763.5758 780.2304 781.8904 812.6215 829.8294 843.7743 867.0044 873.7763 885.7583 889.6924 940.4743 947.9798 955.9805 977.3873 1024.6845 1029.0267 1043.3841 1070.7670 1073.4488 1098.1532 1105.2533 1105.8075 1113.3166 1113.9184 1114.5813 1128.3345 1153.3048 1169.3848 1184.4032 1191.6074 1197.3647 1206.1055 1214.4630 1221.0445 1223.5293 1243.9465 1259.8311 1286.6399 1298.2010 1301.6352 1305.5299 1316.3337 1357.5351 1375.4650 1389.8271 1410.3858 1425.9146 1437.1274 1449.4040 1483.4687 1485.2137 1490.4902 1521.0928 1545.5976 1554.1543 1564.5678 1572.1417 1585.1738 1586.1806 1601.3616 1616.9882 1624.9544 1630.3290 1637.7787 1640.4190 1641.7672 1644.3538 1671.6078 1672.1354 1751.1003 1760.9534 1801.7741 1809.8087 1839.7436 1882.1401 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50.911638 22 6 7 8 16 16 3 2 1
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|1.098449|1.149282|2.230489|1.324422|2.279330|1.470166|1.598962|1.775229|2.327493|1.513336|0.040742|1.441061|2.052885|3.748968|2.279522|4.831460|3.107018|5.132856|4.044819|36.044064|9.083459|12.187231|20.470082|36.858105| |1.154163|1.204048|2.350038|1.391291|2.375975|1.556756|1.689083|1.903890|2.519980|1.622752|0.043725|1.547405|2.212245|3.972147|2.527660|5.403594|3.641299|6.131878|4.821954|51.374288|14.252931|11.964744|11.975236|14.135939|73.516695| |1.014280|1.056506|2.035734|1.202210|2.074752|1.321377|1.423917|1.562956|2.062019|1.358379|0.036722|1.301994|1.773475|3.226386|1.944799|4.002891|2.525801|4.271153|3.097361|26.831647|5.446248|7.259985|10.516383|13.001893|13.943677|36.858105| |0.967445|1.009558|1.935736|1.144891|1.987557|1.249800|1.347206|1.461774|1.918290|1.273568|0.034420|1.220118|1.648828|3.027445|1.775050|3.619974|2.226324|3.737513|2.683449|21.779144|4.184334|6.049529|8.795363|7.729159|9.190927|13.689837|36.858105| |0.905377|0.941431|1.795975|1.057680|1.838777|1.146940|1.227834|1.323378|1.745299|1.168641|0.031677|1.124796|1.474356|2.695212|1.578140|3.163873|1.930890|3.284372|2.260162|18.208125|3.266716|4.586489|5.992964|5.099050|7.009986|7.926964|13.801908|36.858105| |0.885754|0.916793|1.747476|1.024081|1.774862|1.109523|1.180507|1.275128|1.695006|1.137460|0.030918|1.099750|1.411323|2.555770|1.520848|3.022125|1.859023|3.211865|2.143074|17.679946|3.062018|4.106899|5.078018|4.510218|6.728307|6.905474|7.981911|13.749141|36.858105| |0.920377|0.950558|1.818000|1.063276|1.834105|1.157254|1.229476|1.338695|1.789195|1.195131|0.032514|1.157152|1.484756|2.667800|1.620729|3.228005|2.018517|3.524324|2.330959|20.017600|3.452089|4.415108|5.331273|5.077852|8.016826|7.924868|6.860795|7.901439|13.785453|36.858105| |0.985966|1.021027|1.963781|1.152261|1.982143|1.263484|1.349759|1.482914|1.977495|1.308345|0.035508|1.261958|1.663974|2.989929|1.836886|3.718407|2.364635|4.104246|2.805752|25.107555|4.600932|5.677956|7.035338|7.670873|11.922662|13.723747|7.922280|6.862575|7.983023|13.763719|36.858105| |0.820054|0.846160|1.604053|0.936542|1.626574|1.007581|1.065616|1.142344|1.523384|1.031332|0.028104|1.001081|1.250256|2.259442|1.336485|2.617026|1.591977|2.769956|1.793474|14.482581|2.395702|3.221527|3.802158|3.194370|5.024877|4.234671|4.778849|7.045226|10.948916|7.050556|4.777230|448.794386| |2.812073|3.480908|7.592062|5.953865|10.928186|7.388825|12.706114|7.180583|6.960350|5.006325|0.118885|3.908844|5.877783|11.296892|4.019090|6.169807|2.806775|4.593533|2.492362|14.461404|1.869017|2.620349|2.324612|1.587156|2.938943|1.415119|1.351793|1.231214|1.175283|1.214620|1.330350|8.522972|36.858105| |17.558962|8.902509|10.209098|4.272779|7.114844|3.379737|2.768600|2.455169|3.540478|3.232735|0.095775|3.262153|2.060180|3.437624|1.891779|2.969080|1.542047|2.761803|1.390520|9.019701|1.164723|1.575442|1.454859|1.035506|1.927181|0.960221|0.918778|0.862476|0.844095|0.875079|0.934201|6.295053|2.508893|0.500000| |17.571893|8.846125|12.850749|4.890112|7.457596|3.999543|3.127550|2.828122|4.242156|4.075534|0.121319|4.396197|2.313712|3.772885|2.141165|3.295264|1.710179|3.091888|1.519124|9.838856|1.255084|1.687427|1.548604|1.104502|2.069875|1.020044|0.970562|0.908563|0.890784|0.927666|0.994097|6.620017|2.695577|0.300852|0.500000| |17.574586|8.850379|12.879615|4.898171|7.464530|4.010496|3.180355|2.859016|4.234856|3.998097|0.127193|3.842449|2.346882|3.843398|2.160666|3.333595|1.725311|3.107125|1.535441|9.916344|1.267347|1.707212|1.566398|1.115417|2.087797|1.029410|0.980247|0.917038|0.898019|0.934438|1.001737|6.670108|2.766205|0.300774|0.300799|0.500000| |8.807113|17.622050|16.521227|7.261651|12.935804|4.771852|3.726996|3.065939|4.284330|4.065173|0.110949|4.092700|2.486021|4.173168|2.193015|3.404794|1.729832|3.054246|1.552918|9.872675|1.275369|1.737562|1.594069|1.125180|2.090323|1.035919|0.991931|0.925915|0.901073|0.932735|1.000518|6.684538|3.384509|0.211414|0.211074|0.172930|0.500000| |8.811002|17.623741|16.529359|7.268261|12.944897|4.781269|3.811061|3.101261|4.271437|3.982546|0.115181|3.632511|2.524469|4.264582|2.211845|3.444136|1.744150|3.066675|1.569247|9.944773|1.287486|1.758136|1.612609|1.136130|2.107649|1.045228|1.001809|0.934483|0.908182|0.939215|1.007844|6.733503|3.522332|0.211742|0.172924|0.211028|0.302488|0.500000| |3.523304|3.615410|8.320066|4.428481|6.288215|5.462668|4.463791|5.042336|9.727937|8.846520|0.214397|17.588784|3.880899|5.669573|3.843341|5.351692|2.752998|5.171317|2.272103|14.427388|1.746745|2.300665|2.050810|1.466351|2.821374|1.325579|1.235413|1.139666|1.119387|1.183669|1.292235|8.175959|3.327830|0.082204|0.109688|0.097409|0.095232|0.086812|0.500000| |4.879130|5.182327|12.771822|6.163419|8.246661|6.622792|4.737583|4.565099|7.677281|8.808926|0.212915|17.610793|3.422250|5.249493|3.154127|4.566754|2.320483|4.230233|1.980343|12.542270|1.558393|2.081145|1.874210|1.332748|2.529669|1.212739|1.141751|1.057688|1.035260|1.086051|1.177861|7.604995|3.574553|0.108192|0.159121|0.126816|0.137632|0.115063|0.300584|0.500000| |3.464418|3.855464|8.997974|5.340275|7.670169|6.781934|5.522097|5.738225|9.580980|8.804701|0.173561|17.565578|4.245955|6.345937|3.865672|5.452676|2.715719|4.907704|2.279316|14.151886|1.743129|2.330264|2.076912|1.469457|2.799100|1.325263|1.243336|1.144439|1.116489|1.173218|1.280737|8.148189|4.047222|0.081780|0.105654|0.091391|0.106926|0.092175|0.300831|0.300320|0.500000| |2.170143|2.323429|4.990576|3.032004|4.774342|3.944644|4.495064|6.794111|9.461617|4.606487|0.121310|3.800759|8.876129|10.979130|17.628157|16.466277|7.239990|12.781320|4.743812|25.978509|2.893435|3.774829|3.146247|2.202256|4.365770|1.893373|1.723818|1.540251|1.493066|1.596461|1.804217|10.566935|3.703233|0.053737|0.060913|0.062520|0.060763|0.062291|0.109066|0.088036|0.102391|0.500000| |2.127185|2.292894|4.915912|3.021992|4.795823|3.941748|4.490800|6.789549|9.459295|4.608929|0.112349|4.166062|8.877730|10.989109|17.628552|16.465412|7.247821|12.807644|4.745587|25.995384|2.894321|3.775121|3.146465|2.202691|4.367277|1.893752|1.724017|1.540442|1.493342|1.596868|1.804725|10.568770|3.695154|0.052794|0.060708|0.059888|0.061370|0.060475|0.119924|0.093656|0.120527|0.303944|0.500000| |1.480850|1.583131|3.180848|1.942118|3.292764|2.271724|2.590523|3.083401|3.892897|2.356648|0.061325|2.193006|4.019019|7.404038|4.850930|13.105797|8.944448|10.972867|17.629207|56.060348|6.707946|9.274510|6.279221|4.052807|8.208302|3.100985|2.728259|2.287261|2.145023|2.306742|2.763127|14.409127|2.525633|0.038047|0.041505|0.041620|0.042972|0.043072|0.061568|0.054265|0.063296|0.116672|0.126370|0.500000| |1.494944|1.592784|3.200212|1.944243|3.284717|2.271653|2.590289|3.082815|3.892610|2.356019|0.062663|2.134116|4.016854|7.394601|4.850666|13.104328|8.944510|10.973736|17.629161|56.061877|6.708162|9.275984|6.279591|4.052796|8.208029|3.100926|2.728244|2.287232|2.144972|2.306662|2.763025|14.408794|2.526793|0.038391|0.041567|0.042470|0.042754|0.043704|0.059941|0.053099|0.060171|0.126378|0.116700|0.303830|0.500000| |0.982681|1.029715|1.974793|1.173213|2.043612|1.280665|1.388118|1.500796|1.954263|1.296529|0.034954|1.237180|1.701234|3.155768|1.814375|3.722304|2.259726|3.737247|2.747749|21.429934|4.155345|6.442243|9.806599|7.164568|8.468270|8.919418|17.748343|8.932106|5.663633|4.948106|5.645306|31.619204|1.403666|0.025924|0.027328|0.027630|0.028126|0.028442|0.034636|0.032150|0.035087|0.048666|0.048669|0.078665|0.078666|0.500000| |0.874958|0.910590|1.731561|1.020307|1.780022|1.101569|1.178740|1.261875|1.660109|1.116948|0.030276|1.074999|1.399897|2.569634|1.483975|2.957637|1.782986|3.024596|2.066885|16.223761|2.848019|4.075072|5.194408|4.141815|5.857427|5.637239|8.917659|17.754415|8.917843|5.636902|4.949524|53.869152|1.188045|0.023201|0.024355|0.024592|0.024909|0.025153|0.030163|0.028161|0.030397|0.040193|0.040197|0.058408|0.058407|0.214542|0.500000| |0.899393|0.925444|1.767105|1.029373|1.772786|1.118026|1.181495|1.285813|1.728729|1.158886|0.031605|1.126468|1.415991|2.528488|1.548350|3.052474|1.909837|3.376418|2.165383|18.642975|3.072874|3.868310|4.471859|4.123264|6.956788|5.637777|4.948603|5.635012|8.927935|17.754632|8.905233|53.877342|1.162207|0.023774|0.025218|0.025378|0.025219|0.025368|0.032105|0.029423|0.031666|0.042563|0.042576|0.059170|0.059168|0.107491|0.124181|0.500000| |1.017251|1.050870|2.027026|1.186444|2.031665|1.305988|1.391770|1.540512|2.067645|1.362659|0.037025|1.316822|1.729031|3.078082|1.934374|3.913032|2.533576|4.467189|2.988826|28.171664|4.955375|5.696287|6.533022|7.049407|13.481068|8.903198|5.636969|4.948913|5.672446|8.947527|17.747215|31.656294|1.360769|0.026720|0.028553|0.028747|0.028561|0.028742|0.037652|0.034051|0.037062|0.053015|0.053034|0.080453|0.080449|0.124117|0.107505|0.215232|0.500000| |2.581280|3.108487|6.611569|4.827853|8.730745|5.821659|8.934467|6.495044|6.362241|4.374519|0.109351|3.401500|5.983863|12.374350|4.088291|6.456855|2.910406|4.694189|2.612093|14.984373|1.948438|2.751402|2.433703|1.651617|3.048963|1.467174|1.403248|1.274050|1.212020|1.250844|1.372893|8.766122|17.582181|0.064553|0.068252|0.071893|0.082558|0.089112|0.083224|0.086604|0.095524|0.106249|0.100188|0.072920|0.075111|0.040609|0.034158|0.033156|0.038931|0.500000| |2.521936|3.057496|6.482927|4.836583|8.996394|5.846680|8.943727|6.436651|6.328174|4.375615|0.102664|3.655186|5.898454|12.166755|4.044062|6.387200|2.885114|4.658915|2.590916|14.886549|1.936533|2.734126|2.420320|1.643115|3.032553|1.460475|1.397224|1.269088|1.207461|1.245942|1.366982|8.736466|17.574354|0.063245|0.068236|0.068248|0.084739|0.084674|0.087617|0.092094|0.109671|0.099433|0.105067|0.074472|0.072338|0.040430|0.034031|0.033032|0.038760|0.304445|0.500000| |3.017759|3.881313|8.209609|6.731447|14.300639|6.918846|8.927594|5.397775|5.833650|4.540821|0.110978|3.680256|4.438539|8.322524|3.299495|5.160085|2.424412|4.023664|2.184904|12.970376|1.691940|2.370629|2.128727|1.459653|2.689626|1.313121|1.260622|1.155176|1.104368|1.137783|1.238492|8.056733|17.683508|0.075311|0.078924|0.081266|0.106181|0.111921|0.086334|0.097543|0.104941|0.086390|0.086123|0.061477|0.061543|0.036329|0.031069|0.030310|0.035111|0.299238|0.300342|0.500000|
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