Version2.4 2021-05-07T05:44:45Z 10.1021/jm300687e Gaussian16 RevisionB.01 RPOIRIER 17-Apr-2019 #N HF/6-31G(d) OPT=(MaxStep=1) FREQ IOp(6/10=2,6/11=2,6/12=2) DUDE COC[C@@H](c1ccccn1)Nc2[nH]c(=O)c3c(n2)CC[NH2+]CC3 C65421757 RHF 6-31G(d) (6D,7F) COC[C@@H](c1ccccn1)Nc2[nH]c(=O)c3c(n2)CC[NH2+]CC3 C01[X(C16H22N5O2)] 129 C1 389 COC[C@@H](c1ccccn1)Nc1nc2CC[NH2+]CCc2c(=O)[nH]1 COC[C@@H](c1ccccn1)Nc1nc2CC[NH2+]CCc2c(=O)[nH]1 COC[C@H](NC1=NC2=C(CC[NH2+]CC2)C(=O)N1)c3ccccn3 InChIKey=SLVMPHJVPGSXAT-AWEZNQCLSA-O InChI=1S/C16H21N5O2/c1-23-10-14(13-4-2-3-7-18-13)20-16-19-12-6-9-17-8-5-11(12)15(22)21-16/h2-4,7,14,17H,5-6,8-10H2,1H3,(H2,19,20,21,22)/p+1/t14-/m0/s1 InChI=1/C16H21N5O2/c1-23-10-14(13-4-2-3-7-18-13)20-16-19-12-6-9-17-8-5-11(12)15(22)21-16/h2-4,7,14,17H,5-6,8-10H2,1H3,(H2,19,20,21,22)/p+1/t14-/m0/s1/fC16H22N5O2/h17,20-21H/q+1 COC[C@@H](c1ccccn1)Nc2[nH]c(=O)c3c(n2)CC[NH2+]CC3 C01[X(C16H22N5O2)] 129 C01 389 COC[C@@H](c1ccccn1)Nc1nc2CC[NH2+]CCc2c(=O)[nH]1 COC[C@@H]([C]1[CH][CH][CH][CH][N]1)[NH][C]1[N][C]2[C]([C](=O)N1)CC[NH2]CC2 COC[C@H](N[C]1[N][C]2CC[NH2]CC[C]2C(=O)N1)[C]3[CH][CH][CH][CH][N]3 InChIKey=SRLGUAADYLTTRN-AWEZNQCLSA-N InChI=1S/C16H22N5O2/c1-23-10-14(13-4-2-3-7-18-13)20-16-19-12-6-9-17-8-5-11(12)15(22)21-16/h2-4,7,14H,5-6,8-10,17H2,1H3,(H2,19,20,21,22)/t14-/m0/s1 InChI=1/C16H22N5O2/c1-23-10-14(13-4-2-3-7-18-13)20-16-19-12-6-9-17-8-5-11(12)15(22)21-16/h2-4,7,14H,5-6,8-10,17H2,1H3,(H2,19,20,21,22)/t14-/m0/s1/f/h20-21H 1944.6001485843 -1040.495909 1-A 9753.0242 84 305 389 |A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A| -20.63990 -20.62376 -15.85963 -15.72019 -15.68840 -15.64774 -15.64464 -11.48171 -11.45677 -11.45284 -11.44208 -11.41329 -11.38209 -11.36999 -11.36779 -11.36220 -11.36064 -11.34695 -11.34171 -11.33541 -11.33062 -11.31517 -11.30940 -1.50424 -1.49136 -1.46813 -1.44721 -1.35978 -1.33039 -1.31929 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|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A| 0.01056 0.01911 0.04801 0.06010 0.06766 0.08852 0.10807 0.11818 0.13216 0.13376 0.14371 0.15528 0.16081 0.17363 0.17531 0.17988 0.18846 0.19428 0.20624 0.22183 0.22343 0.22919 0.23273 0.23629 0.23959 0.24512 0.24675 0.25591 0.25990 0.26161 0.27147 0.28252 0.29298 0.30089 0.32098 0.33004 0.33330 0.34991 0.36016 0.37186 0.37876 0.39101 0.39898 0.42268 0.43093 0.44802 0.46116 0.48068 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11.57182
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|XX|YY|ZZ|XY|XZ|YZ| 87.4898 -41.5750 -45.9147 -33.3232 11.0222 -0.3800
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MUNgauss RevisionA2.1 retrievium 07-May-2021 DUDE COC[C@@H](c1ccccn1)Nc2[nH]c(=O)c3c(n2)CC[NH2+]CC3 C65421757 RHF 6-31G(d) (6D,10F) C1 316.177350 |X|Y|Z| 87.023101 36.770160 28.769665
45.153175 19 6 7 14 5
|36.858105| |13.640830|73.516695| |8.133368|24.420742|36.858105| |5.197062|14.276618|12.453286|36.858105| |4.276622|10.298951|8.952983|17.614197|0.500000| |4.565911|11.696690|7.539766|12.496430|0.247289|36.858105| |3.989266|9.084036|5.943371|7.541102|0.194281|13.724220|36.858105| |3.366975|7.210678|4.288448|5.032507|0.130461|8.003923|13.787745|36.858105| |3.194260|6.845118|3.809307|4.493256|0.111940|7.014499|7.989409|13.752132|36.858105| |3.498296|7.869941|4.212188|5.210226|0.122102|8.377248|7.049791|8.038230|13.796242|36.858105| |4.159093|10.283780|5.606888|7.841196|0.165031|14.453370|8.028919|6.909811|8.007232|14.396269|53.358707| |4.586694|11.948772|7.742683|13.127564|0.256309|7.890100|5.148111|3.987808|3.903226|4.840594|9.884519|53.358707| |3.872963|8.995877|5.861737|7.737088|0.201574|5.225715|3.940112|3.188754|3.109021|3.679712|6.663706|19.607254|36.858105| |3.320700|7.295765|4.310936|5.197451|0.134490|4.113977|3.220246|2.751753|2.780809|3.324433|5.716450|11.347478|14.036177|53.358707| |3.283168|7.223779|4.036477|4.839280|0.120227|4.108383|3.181467|2.781815|2.895358|3.561318|6.085510|10.432115|9.276242|25.949593|0.500000| |2.791518|5.793326|3.434588|3.901576|0.106372|3.204413|2.653415|2.316281|2.326350|2.690039|4.392117|7.215890|7.848256|18.680323|0.261152|36.858105| |2.491009|5.051124|2.900537|3.227785|0.087038|2.784370|2.344408|2.097721|2.140274|2.471318|3.918732|5.726339|5.443260|11.552690|0.218675|15.890296|73.516695| |2.683570|5.461579|3.386184|3.757956|0.108181|3.012127|2.570736|2.219705|2.172485|2.439901|3.947878|6.385390|6.953545|10.919513|0.161652|13.129575|14.308721|36.858105| |2.990568|6.179725|4.072574|4.547600|0.137787|3.431843|2.931497|2.456952|2.344751|2.604929|4.292671|7.403591|8.392839|9.832513|0.145524|7.926779|9.584059|14.050201|36.858105| |3.614050|7.928807|5.589042|6.705250|0.207274|4.502998|3.673931|2.951784|2.780191|3.130864|5.404060|11.292330|14.537954|11.136369|0.163972|6.741953|8.421501|7.912429|14.113769|53.358707| |2.693017|5.347720|3.571097|3.789103|0.119164|2.963109|2.661687|2.248881|2.107555|2.270829|3.635894|5.527613|5.277463|6.250644|0.102810|4.991747|6.974262|7.626564|12.579165|10.823115|36.858105| |2.546959|4.853220|3.121080|3.120647|0.093859|2.511166|2.282886|1.965387|1.855882|1.990136|3.133235|4.518354|4.111242|5.180360|0.088541|4.264711|6.335370|6.106614|7.450377|7.371631|12.487659|36.858105| |2.196133|4.160584|2.583945|2.625924|0.077401|2.189128|1.993319|1.752483|1.680572|1.806762|2.802335|3.891066|3.510463|4.759406|0.083081|4.188619|6.578106|5.946167|5.853966|5.778395|7.516152|12.635185|53.358707| |2.087246|3.882126|2.382945|2.374711|0.069373|2.004887|1.842391|1.631757|1.565525|1.673638|2.572980|3.468669|3.038826|4.120908|0.073600|3.534130|5.722018|4.629604|4.577331|4.866271|5.640889|9.262436|25.690167|0.500000| |2.029862|3.864624|2.410401|2.492284|0.074349|2.107596|1.937695|1.712646|1.640004|1.752337|2.697508|3.659631|3.261762|4.413953|0.077724|3.856792|6.134899|5.373824|5.311586|5.340508|7.049279|9.229033|25.674084|0.329307|0.500000| |2.198217|4.199418|2.542203|2.619206|0.075314|2.199790|1.968164|1.742798|1.698757|1.853768|2.880605|4.045131|3.726408|5.440778|0.094968|5.245309|8.554612|7.447288|5.917612|5.768483|5.948488|7.362572|17.140260|0.256476|0.256265|36.858105| |2.251623|4.430332|2.697993|2.907281|0.083965|2.438417|2.148685|1.897451|1.861627|2.054982|3.220997|4.658350|4.486691|6.914281|0.116644|7.555790|11.806103|12.641359|7.488845|6.810309|6.339121|6.043015|10.303458|0.157110|0.196275|12.515961|36.858105| |17.637835|16.895065|5.871788|4.354637|0.100246|4.067665|3.557346|3.143826|3.097856|3.435811|5.385536|5.562789|3.483165|4.252415|0.088181|2.645364|4.289088|2.490668|2.695565|4.320467|2.412967|2.304348|2.766719|0.053921|0.052292|2.065019|2.116570|0.500000| |17.524213|16.458569|7.209655|4.738557|0.112870|4.379980|4.111436|3.499377|3.219363|3.372832|5.267385|5.392217|3.373913|3.932186|0.078949|2.473249|3.943745|2.418077|2.712335|4.413114|2.512378|2.375981|2.786320|0.054314|0.053038|2.019240|2.060381|0.299839|0.500000| |17.508988|16.450752|7.213853|4.703720|0.112498|3.914784|3.447688|2.914261|2.757686|3.006152|4.846907|5.893676|3.894728|4.569097|0.090244|2.887905|4.558795|2.828889|3.168719|5.118068|2.884656|2.796472|3.244158|0.063315|0.060407|2.371534|2.381520|0.299687|0.299371|0.500000| |7.189183|16.551388|17.509548|8.871455|0.217863|5.507087|4.579180|3.491407|3.153295|3.461198|6.027638|9.560806|6.242946|6.153291|0.112826|3.703959|5.456473|3.791545|4.735210|8.930914|4.189830|3.697954|4.020297|0.075463|0.075251|2.865576|2.986931|0.146668|0.172869|0.213161|0.500000| |7.300666|16.537314|17.495438|8.861811|0.216255|6.904343|6.489265|4.594187|3.849776|3.993722|6.763594|7.648756|4.539396|4.773408|0.091951|2.914092|4.459773|2.929858|3.503645|6.200976|3.239581|2.864368|3.235924|0.061522|0.062266|2.297783|2.409936|0.147670|0.216941|0.176877|0.300929|0.500000| |3.889788|8.478641|5.993756|6.968959|0.203607|8.875626|17.724720|8.897515|5.657866|5.044396|7.768281|6.333127|3.757835|4.127225|0.081293|2.554618|3.988241|2.545950|2.963966|5.035849|2.774691|2.375047|2.783370|0.052604|0.055346|1.983401|2.142551|0.093878|0.114677|0.095757|0.132512|0.200913|0.500000| |2.994872|6.125897|3.663773|4.088508|0.110493|5.666135|8.915621|17.723410|8.891300|5.678840|6.766886|4.505031|2.756034|3.275492|0.067102|2.072585|3.359682|2.012602|2.223966|3.562551|2.079412|1.833924|2.232754|0.042663|0.044734|1.618751|1.747402|0.077886|0.088326|0.073121|0.085546|0.112111|0.213807|0.500000| |2.785739|5.738052|3.154969|3.586420|0.091434|5.028537|5.652918|8.856525|17.746930|8.915627|7.762848|4.392285|2.667040|3.326433|0.070974|2.087249|3.463284|1.951564|2.080274|3.282064|1.888904|1.681852|2.094301|0.040018|0.041843|1.557455|1.698816|0.076352|0.078454|0.067621|0.074628|0.089008|0.123787|0.212174|0.500000| |3.166955|6.888851|3.580428|4.262967|0.101621|5.904194|5.044327|5.676990|8.905784|17.720369|12.713384|5.808419|3.379342|4.351006|0.097764|2.616416|4.366878|2.331757|2.430747|3.881166|2.111133|1.870758|2.345053|0.044454|0.046422|1.788054|1.984963|0.088970|0.083741|0.076616|0.084546|0.093177|0.109100|0.124152|0.213864|0.500000| |4.446353|11.464905|6.341886|9.187803|0.184174|7.739705|4.953887|4.055727|4.215552|5.632427|12.087915|25.975625|9.426652|10.498370|0.235165|4.938320|7.382357|4.122561|4.440546|8.109604|3.412596|2.889250|3.494464|0.064288|0.067337|2.717612|3.123871|0.115672|0.105862|0.113173|0.154122|0.134873|0.118552|0.092152|0.096700|0.142143|0.500000| |2.884381|5.735150|3.996110|4.174116|0.137028|3.198497|2.919318|2.421575|2.223299|2.365607|3.801862|5.706522|5.150988|5.705944|0.095949|4.221162|6.006760|5.678479|9.024565|10.857272|17.625999|9.014871|7.589270|0.128321|0.147721|4.512289|4.691665|0.070433|0.075799|0.085750|0.132521|0.102711|0.086613|0.062402|0.055003|0.060219|0.096038|0.500000| |2.370233|4.696261|3.091161|3.363264|0.106507|2.738139|2.500079|2.144549|2.014976|2.153860|3.392763|4.876131|4.504438|5.561685|0.093777|4.537712|6.582906|6.694171|8.859705|8.386727|17.508229|8.835830|9.622497|0.147595|0.216484|5.592420|6.294852|0.059709|0.062121|0.069389|0.096819|0.079411|0.072316|0.055500|0.050535|0.055882|0.085631|0.303946|0.500000| |2.815889|5.292160|3.360803|3.239046|0.094832|2.574796|2.316745|1.989156|1.884826|2.034107|3.221931|4.721076|4.275840|5.386751|0.092397|4.348915|6.462274|5.880536|6.994095|7.460941|8.763641|17.633020|12.389788|0.220977|0.180988|6.860286|5.479832|0.070532|0.071969|0.087989|0.113731|0.084439|0.066625|0.051333|0.047351|0.053178|0.083958|0.205431|0.173055|0.500000| |2.397355|4.493708|2.900388|2.857668|0.086743|2.340920|2.175361|1.882136|1.762274|1.863309|2.898792|3.992197|3.473831|4.328122|0.075915|3.450169|5.276489|4.581493|5.496572|6.062853|8.842287|17.617207|12.491383|0.233499|0.223095|5.522946|4.622495|0.060128|0.063225|0.073038|0.094587|0.075957|0.063674|0.049301|0.044565|0.048526|0.071494|0.224990|0.206530|0.301134|0.500000| |2.363789|4.470076|2.666000|2.684488|0.075756|2.239148|1.988498|1.758000|1.718673|1.885575|2.942825|4.175180|3.828785|5.632818|0.098991|5.324976|8.731823|6.931727|5.647675|5.792451|5.355935|6.824465|12.367246|0.221617|0.180961|17.638143|8.770419|0.061875|0.059640|0.071837|0.084421|0.066290|0.055470|0.045214|0.043709|0.050609|0.078255|0.118578|0.130998|0.207918|0.143294|0.500000| |1.964118|3.714912|2.222489|2.286278|0.065502|1.964156|1.775862|1.592141|1.558849|1.691907|2.592983|3.490031|3.111505|4.577539|0.082581|4.304046|7.485566|5.475572|4.482666|4.674581|4.586764|5.524373|12.479883|0.231677|0.224846|17.610031|8.801984|0.051743|0.050480|0.058510|0.068505|0.056462|0.049639|0.041321|0.040009|0.045628|0.066243|0.102142|0.126380|0.143230|0.127662|0.300373|0.500000| |2.076875|4.087094|2.515377|2.746414|0.080897|2.339727|2.093229|1.857446|1.813978|1.981186|3.073628|4.289755|4.011200|5.929945|0.102272|5.892566|9.427497|8.797891|6.532641|6.187029|6.221059|5.605162|9.628195|0.147575|0.215987|8.891972|17.478721|0.054138|0.053488|0.060450|0.076395|0.063426|0.058312|0.047820|0.046147|0.053037|0.079933|0.128883|0.196764|0.132111|0.125834|0.173295|0.209826|0.500000| |2.134570|4.185820|2.488822|2.684674|0.076018|2.304122|2.025572|1.812418|1.802240|2.001736|3.108346|4.353128|4.074933|6.687035|0.118172|7.613548|14.344121|9.062513|5.639605|5.750794|4.699164|4.567470|7.606342|0.128131|0.147260|9.054325|17.609389|0.056549|0.054100|0.062277|0.075200|0.061757|0.055492|0.046332|0.045965|0.054400|0.083531|0.103993|0.130088|0.121073|0.102740|0.207686|0.222320|0.305226|0.500000|
1039.199688 -6302.670371 2418.961097 -140.586643 -2985.096229 1944.600289 -1040.495941 2.001247 406200000000000F 434C1F0654F41743 42D54C8409CF986F 41A0BC664BFFFFFE 4051800000000001 430525FD4C0704FE