Version2.0 2020-01-30T15:06:34Z 10.1021/jm300687e Gaussian16 RevisionB.01 CFLINN 29-Sep-2019 #N HF/6-31G(d) OPT=(MaxStep=1) FREQ IOp(6/10=2,6/11=2,6/12=2) DUDE COC(=O)Nc4nc3ccc(Oc2ccc(NC(=O)Nc1cc(C(F)(F)F)ccc1F)cc2)nc3[nH]4 389386 CHEMBL244101 RHF 6-31G(d) (6D,7F) COC(=O)Nc4nc3ccc(Oc2ccc(NC(=O)Nc1cc(C(F)(F)F)ccc1F)cc2)nc3[nH]4 C01[X(C22H16F4N6O4)] 150 C1 572 COC(=O)Nc1nc2c([nH]1)nc(cc2)Oc1ccc(cc1)NC(=O)Nc1cc(ccc1F)C(F)(F)F COC(=O)Nc1nc2c([nH]1)nc(cc2)Oc1ccc(cc1)NC(=O)Nc1cc(ccc1F)C(F)(F)F COC(=O)Nc1[nH]c2nc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)ccc2n1 InChIKey=YZBMZVFTUOENSZ-UHFFFAOYSA-N InChI=1S/C22H16F4N6O4/c1-35-21(34)32-19-28-15-8-9-17(30-18(15)31-19)36-13-5-3-12(4-6-13)27-20(33)29-16-10-11(22(24,25)26)2-7-14(16)23/h2-10H,1H3,(H2,27,29,33)(H2,28,30,31,32,34) InChI=1/C22H16F4N6O4/c1-35-21(34)32-19-28-15-8-9-17(30-18(15)31-19)36-13-5-3-12(4-6-13)27-20(33)29-16-10-11(22(24,25)26)2-7-14(16)23/h2-10H,1H3,(H2,27,29,33)(H2,28,30,31,32,34)/f/h27,29,31-32H COC(=O)Nc4nc3ccc(Oc2ccc(NC(=O)Nc1cc(C(F)(F)F)ccc1F)cc2)nc3[nH]4 C01[X(C22H16F4N6O4)] 150 C01 572 COC(=O)Nc1nc2c([nH]1)nc(cc2)Oc1ccc(cc1)NC(=O)Nc1cc(ccc1F)C(F)(F)F COC(=O)Nc1nc2c([nH]1)nc(cc2)Oc1ccc(cc1)NC(=O)Nc1cc(ccc1F)C(F)(F)F COC(=O)Nc1[nH]c2nc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)ccc2n1 InChIKey=YZBMZVFTUOENSZ-UHFFFAOYSA-N InChI=1S/C22H16F4N6O4/c1-35-21(34)32-19-28-15-8-9-17(30-18(15)31-19)36-13-5-3-12(4-6-13)27-20(33)29-16-10-11(22(24,25)26)2-7-14(16)23/h2-10H,1H3,(H2,27,29,33)(H2,28,30,31,32,34) InChI=1/C22H16F4N6O4/c1-35-21(34)32-19-28-15-8-9-17(30-18(15)31-19)36-13-5-3-12(4-6-13)27-20(33)29-16-10-11(22(24,25)26)2-7-14(16)23/h2-10H,1H3,(H2,27,29,33)(H2,28,30,31,32,34)/f/h27,29,31-32H 3456.3092527604 -1866.4191093 1-A 37266.7925 129 443 572 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10.99222
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9948.5382 64617.4702 69334.8602 0.99998 -0.00353 -0.00474 0.00357 0.99994 0.01010 0.00470 -0.01012 0.99994 1 0.00871 0.00134 0.00125 0.18141 0.02793 0.02603 5.39 10.37 14.57 22.20 32.72 43.27 61.00 70.49 76.62 104.78 110.30 137.74 159.18 166.80 186.50 216.25 237.72 263.26 268.50 319.08 324.11 346.06 375.57 429.72 447.68 450.19 473.58 484.38 493.19 521.22 539.67 573.60 593.14 621.77 640.44 649.63 670.30 694.33 717.93 728.91 755.79 784.67 810.94 822.89 841.29 845.11 898.35 904.41 917.12 925.29 965.76 973.39 1007.09 1009.30 1046.32 1086.99 1132.28 1148.21 1148.92 1173.06 1176.74 1198.05 1205.61 1212.66 1247.37 1253.34 1255.81 1299.53 1327.95 1332.13 1335.68 1352.41 1366.13 1372.68 1398.76 1478.11 1502.39 1530.36 1550.08 1551.83 1570.17 1579.25 1579.99 1604.76 1605.93 1646.82 1696.37 1717.06 1737.89 1753.95 1763.68 1828.10 1836.76 1858.88 1868.85 1887.29 1889.63 1911.23 1917.62 1936.86 1949.62 1958.24 1980.62 1996.25 2023.11 2032.12 2038.66 2041.14 2054.58 2088.05 2135.82 2148.63 2253.41 2279.86 2300.96 2319.27 2358.10 2361.72 2371.80 2389.30 2395.07 2420.14 2439.99 2470.85 2514.79 2572.67 2593.68 2601.49 2617.61 2622.81 2625.63 2666.77 2822.97 2845.17 4691.59 4816.01 4823.13 4839.37 4878.53 4880.34 4883.85 4894.60 4914.84 4926.15 4961.04 4983.72 5573.82 5577.52 5600.45 5605.13 0.403387 0.432535 0.433479 0.333559 -1866.015722 -1865.986574 -1865.985630 -1866.085550 3.351333D-04
MUNgauss RevisionA2.0 retrievium 30-Jan-2020 DUDE COC(=O)Nc4nc3ccc(Oc2ccc(NC(=O)Nc1cc(C(F)(F)F)ccc1F)cc2)nc3[nH]4 389386 CHEMBL244101 RHF 6-31G(d) (6D,10F) C1 504.116916 |X|Y|Z| 63.672942 38.513363 178.127000
75.875000 25 6 7 8 19 5 1
|36.858105| |13.405560|73.516695| |8.167133|25.718095|36.858105| |7.172785|15.203844|15.934230|73.516695| |5.418200|15.429618|14.015164|14.938507|53.358707| |4.004001|9.605238|7.800257|11.837464|18.781096|36.858105| |3.258070|7.498308|5.288126|8.185985|11.115246|14.861211|53.358707| |2.777755|6.022887|4.202603|7.111476|7.529020|9.054161|18.698981|36.858105| |2.313339|4.855227|3.220611|5.516325|5.420608|5.478647|10.195597|13.721216|36.858105| |2.098261|4.278196|2.822782|5.013788|4.494054|4.332152|6.978504|8.062500|13.824877|36.858105| |2.187176|4.400086|2.960629|5.464503|4.555174|4.397607|6.398754|7.060035|7.944807|13.577867|36.858105| |1.938398|3.806957|2.504437|4.677380|3.723729|3.387033|4.801286|4.708957|5.301239|8.180899|14.124166|73.516695| |1.924658|3.708982|2.437529|4.672748|3.505552|3.097275|4.188412|3.864342|4.001256|5.274239|8.049355|24.635399|36.858105| |1.886257|3.595102|2.346654|4.532297|3.321422|2.872423|3.828087|3.410627|3.456262|4.295624|5.915600|14.200667|13.799966|36.858105| |1.812168|3.386977|2.185985|4.277179|3.016409|2.529644|3.306688|2.827470|2.801733|3.305227|4.251248|9.274648|7.942261|13.770251|36.858105| |1.773469|3.286054|2.110536|4.152035|2.883064|2.390481|3.104840|2.620766|2.581218|3.004769|3.805363|8.172860|6.875703|7.946009|13.713801|36.858105| |1.675820|3.054576|1.933730|3.813214|2.599413|2.103679|2.714497|2.229766|2.179273|2.461946|2.982542|6.094114|4.553321|5.131050|7.739331|13.464691|53.358707| |1.545611|2.801271|1.752334|3.426133|2.352733|1.883442|2.444810|1.986788|1.954642|2.187848|2.578179|5.214901|3.701005|4.320993|6.248764|7.677699|18.974449|36.858105| |1.499318|2.729961|1.704465|3.306140|2.305194|1.850685|2.422155|1.974935|1.961433|2.205871|2.578934|5.258262|3.679577|4.517363|6.514196|6.611876|11.435987|15.902003|73.516695| |1.469044|2.634305|1.630684|3.185297|2.170244|1.712586|2.216451|1.774152|1.737226|1.912960|2.211009|4.367231|2.981104|3.321294|4.354842|5.235295|11.387390|13.863239|14.938878|53.358707| |1.355248|2.418738|1.482005|2.872998|1.970663|1.541281|2.002930|1.588648|1.560510|1.702854|1.931542|3.773457|2.497173|2.777981|3.471690|3.865128|7.148373|7.672976|11.755027|18.534456|36.858105| |1.288230|2.306877|1.409000|2.710900|1.884528|1.474950|1.930280|1.531832|1.515929|1.655822|1.860574|3.643646|2.378800|2.688026|3.302755|3.469366|5.915932|6.252428|11.783541|10.451608|13.754289|36.858105| |1.196026|2.132675|1.291663|2.471266|1.725078|1.339538|1.756829|1.382424|1.368821|1.481497|1.641830|3.177604|2.030032|2.259336|2.673378|2.768290|4.506708|4.300026|8.017202|6.961107|7.931314|13.693895|36.858105| |1.135509|2.030799|1.225900|2.329162|1.645486|1.277477|1.685799|1.325390|1.320168|1.427082|1.565868|3.026319|1.905435|2.129040|2.462329|2.470205|3.840204|3.535994|6.946422|5.228391|5.066112|7.686113|12.665370|36.858105| |1.112678|2.002281|1.211027|2.291413|1.637186|1.278369|1.698383|1.343330|1.349913|1.469630|1.607930|3.140212|1.972473|2.202599|2.529733|2.523806|3.852193|3.529046|7.135205|5.002089|4.561449|6.683894|8.133620|14.395060|97.533100| |1.062306|1.893989|1.136352|2.150689|1.523535|1.176073|1.553913|1.214211|1.209264|1.298492|1.412489|2.708025|1.684554|1.854995|2.104653|2.120210|3.253011|2.879671|5.484995|4.287253|4.013432|5.278252|8.116272|14.393096|20.107311|97.533100| |1.172468|2.096207|1.265609|2.405856|1.696922|1.316054|1.733748|1.360766|1.351377|1.456532|1.598341|3.071159|1.928222|2.185716|2.520586|2.461071|3.761095|3.434561|6.937067|4.877508|4.477811|6.403814|8.132663|14.386101|20.176080|20.125568|97.533100| |1.162833|2.060780|1.241786|2.376551|1.649868|1.272244|1.663627|1.299935|1.281440|1.376602|1.519175|2.911794|1.847056|2.019151|2.356251|2.480237|4.038378|3.662322|6.446194|6.177847|6.796791|7.875973|13.808304|7.599717|12.353858|15.807134|12.771878|36.858105| |1.210899|2.138388|1.290273|2.482282|1.705895|1.313390|1.708569|1.333389|1.307319|1.402487|1.556156|2.974997|1.899673|2.055013|2.413593|2.611820|4.370082|3.892118|6.437739|7.082025|7.840612|6.847004|7.988937|5.048679|9.282073|10.460885|9.468284|13.731058|36.858105| |1.305658|2.311950|1.405797|2.722572|1.857806|1.438836|1.865072|1.464522|1.432368|1.546266|1.736868|3.343782|2.173958|2.360108|2.845002|3.171835|5.611007|5.168879|7.978584|10.919972|13.687389|8.030625|7.013199|4.514246|8.812439|8.760378|8.835952|8.031744|13.925566|36.858105| |1.353977|2.387539|1.452177|2.825900|1.908557|1.473595|1.899925|1.487196|1.445634|1.554569|1.751136|3.348728|2.179515|2.320164|2.774596|3.185657|5.677681|4.774337|6.999769|9.846779|8.169621|5.317577|4.698651|3.427574|6.953138|6.910016|6.967988|5.299717|8.157375|14.236499|97.533100| |1.804607|3.371784|2.175649|4.257743|3.001607|2.516693|3.290667|2.814060|2.790650|3.295446|4.240960|9.301914|7.984460|6.912212|7.944886|13.725167|10.804802|5.230569|8.130034|5.622629|3.193916|2.866886|2.372986|2.136907|4.932627|4.217612|4.743023|2.177776|2.310025|2.753621|6.396010|36.858105| |1.880231|3.581707|2.337324|4.516632|3.306157|2.857349|3.807150|3.389887|3.435973|4.271137|5.881946|14.224309|13.816972|7.961125|6.862297|7.910529|7.047229|3.932187|6.559560|4.377149|2.627672|2.435215|2.068052|1.907040|4.426835|3.804408|4.273781|1.902653|1.989236|2.306141|5.307120|13.772620|36.858105| |2.528044|5.122531|3.583668|6.820201|5.465498|5.501855|7.300832|7.859394|6.748157|7.932081|14.586075|14.761846|7.068137|5.683960|4.335052|3.929364|4.235282|2.652634|4.642822|3.113526|1.985471|1.891273|1.666440|1.576203|3.599192|3.198975|3.633772|1.550595|1.600292|1.794264|4.105262|4.318183|5.650615|53.358707| |2.912214|6.164324|4.489919|8.222054|7.397185|8.758283|11.406571|13.744918|8.051861|7.186321|8.640285|9.793031|4.749666|4.143495|3.394134|3.134033|3.555550|2.279924|3.992588|2.740659|1.776932|1.697775|1.516285|1.440852|3.272976|2.950135|3.330826|1.422661|1.467434|1.628332|3.735635|3.377013|4.117508|19.671356|36.858105| |3.673427|8.059202|6.531659|12.306026|10.785227|14.026682|11.648996|8.687779|5.450548|4.758419|5.403249|7.214904|3.804287|3.497423|3.045559|2.866250|3.364939|2.171920|3.769459|2.654492|1.730144|1.643913|1.476770|1.398281|3.145687|2.875253|3.240888|1.396778|1.447721|1.602411|3.701140|3.029421|3.478704|10.753100|13.882866|53.358707| |3.978257|8.379375|6.982841|15.620901|9.573012|9.069209|8.187300|6.011814|4.305162|3.988635|4.684020|6.675488|3.718738|3.500391|3.149865|2.998819|3.562563|2.285881|3.928256|2.805053|1.819708|1.715443|1.537223|1.445857|3.231632|2.969064|3.354585|1.458286|1.519891|1.689556|3.924791|3.132863|3.483632|9.235264|8.898199|26.043557|0.500000| |17.674605|16.939373|5.964327|9.158532|6.185257|3.449748|3.987191|2.499477|2.122734|1.923331|1.978612|3.140073|1.745711|1.712035|1.646665|1.612499|2.083449|1.421785|2.459305|1.847469|1.260481|1.202622|1.122710|1.069776|2.359736|2.261215|2.483854|1.094023|1.136580|1.218649|2.838120|1.640016|1.706646|3.053610|2.561782|4.246304|0.091379|0.500000| |17.647732|16.427897|7.227159|12.716697|6.687454|3.810423|4.221901|2.701415|2.259997|2.072837|2.182219|3.459568|1.949585|1.938688|1.874458|1.821711|2.352213|1.601746|2.769338|2.071190|1.406597|1.339045|1.243218|1.180727|2.593988|2.482112|2.756288|1.207386|1.255652|1.353457|3.149275|1.829909|1.892119|3.446995|2.879240|4.928082|0.111159|0.298511|0.500000| |17.647421|16.427776|7.224993|12.714970|6.685269|3.808439|4.220331|2.700024|2.258917|2.071680|2.180771|3.457404|1.947315|1.895064|1.833697|1.817889|2.348954|1.581809|2.705294|2.056063|1.388236|1.310417|1.214824|1.146967|2.525600|2.414455|2.653575|1.185439|1.241620|1.342851|3.156018|1.863004|1.930065|3.444487|2.877221|4.924299|0.111024|0.298511|0.299841|0.500000| |5.094359|14.603170|9.366918|10.820918|26.030919|9.438303|10.378133|4.991360|3.778728|3.083069|3.022949|4.446383|2.332195|2.212025|2.011747|1.924073|2.374668|1.592165|2.784330|2.007750|1.348587|1.295389|1.192126|1.142121|2.560933|2.388408|2.648573|1.141755|1.177115|1.275029|2.940416|2.002106|2.201851|4.730977|4.550501|7.952695|0.143795|0.126528|0.125251|0.125205|0.500000| |2.180072|4.572245|2.944788|4.942961|4.961897|4.706401|8.962655|8.845833|17.730273|8.892931|5.629219|7.579743|3.333045|2.946439|2.446940|2.270694|2.655258|1.771634|3.170751|2.162767|1.440830|1.406320|1.279298|1.240212|2.857468|2.569148|2.854533|1.200634|1.221257|1.329187|3.012991|2.437893|2.930820|6.652959|5.672739|5.965909|0.099512|0.056373|0.058832|0.058809|0.100093|0.500000| |1.878943|3.780992|2.440174|4.326979|3.816359|3.506961|5.568085|5.675078|8.865693|17.767845|8.913691|13.452831|4.894952|4.035328|3.136402|2.860102|3.211256|2.120974|3.832339|2.526921|1.662665|1.628096|1.460731|1.415136|3.303770|2.900858|3.239569|1.353963|1.372899|1.507815|3.393709|3.130329|4.016805|7.764509|5.120741|5.108704|0.090655|0.048324|0.051608|0.051580|0.074029|0.211292|0.500000| |1.881631|3.607012|2.347652|4.481948|3.355254|2.908917|3.925811|3.504374|3.594696|4.448680|5.849314|12.990671|8.964068|17.735774|8.920482|5.647526|5.647359|3.733754|7.197721|4.018009|2.551929|2.526960|2.157679|2.071638|4.829564|4.075564|4.852609|1.922655|1.932184|2.183009|4.778950|4.973846|5.667544|7.450785|4.151510|4.739838|0.095225|0.047585|0.053966|0.051923|0.062414|0.085505|0.116742|0.500000| |1.755683|3.255362|2.081329|4.066436|2.849490|2.352770|3.068433|2.573242|2.539600|2.924983|3.609247|7.504501|5.658536|8.939098|17.809248|8.912036|9.579702|6.744532|14.179857|6.260277|3.762853|3.689404|2.946285|2.732405|6.282177|5.170127|6.424923|2.543225|2.564893|3.011560|6.433882|5.652611|4.953615|5.039049|3.031080|3.791263|0.080423|0.044469|0.050866|0.049092|0.053047|0.062477|0.077612|0.215179|0.500000| |1.677123|3.040350|1.918648|3.793536|2.563017|2.059178|2.645494|2.154682|2.093774|2.340672|2.809612|5.633987|4.089635|4.307423|5.788377|9.327097|26.082549|9.392483|10.856849|10.855942|5.035129|3.987599|3.129446|2.635141|5.892843|5.115539|5.730329|2.901123|3.237329|4.210689|10.218551|7.551971|4.895476|4.023954|2.517387|3.281590|0.071294|0.042562|0.047828|0.048371|0.047796|0.052237|0.062172|0.098480|0.144917|0.500000| |1.503109|2.683515|1.660465|3.258234|2.197065|1.726636|2.222534|1.770850|1.722621|1.885740|2.180750|4.263197|2.898928|3.136180|4.007062|4.999559|10.810809|9.332257|10.831122|26.096681|9.423498|5.749416|4.308009|3.305157|7.072987|6.335297|6.954829|4.106518|4.984614|7.762843|19.738794|4.165944|3.208317|3.101158|2.015842|2.679758|0.058147|0.038524|0.043145|0.043222|0.041407|0.043740|0.050585|0.076908|0.113056|0.252437|0.500000| |1.308604|2.358013|1.445927|2.776275|1.945757|1.533262|2.015077|1.610415|1.602702|1.764302|1.988497|3.936276|2.583923|2.985841|3.714344|3.773219|6.243124|6.817531|15.221165|9.451627|8.957296|17.823923|8.890977|7.144813|16.056348|10.838745|14.744537|5.628691|4.946761|5.691063|9.627048|3.042524|2.599690|2.729490|1.785842|2.331986|0.049428|0.033896|0.037795|0.036832|0.037136|0.041222|0.048349|0.078437|0.118671|0.111606|0.142687|0.500000| |1.100523|1.947040|1.167340|2.224617|1.551247|1.191381|1.561121|1.214508|1.198486|1.281440|1.403203|2.674608|1.677715|1.822981|2.091213|2.179345|3.461573|3.042923|5.414608|4.921503|4.916643|5.618051|8.912112|6.996614|11.415561|17.978572|11.989813|17.773727|8.915954|5.692868|9.595767|1.941033|1.720306|1.945708|1.320690|1.768643|0.037592|0.028869|0.031727|0.031118|0.029925|0.031329|0.035077|0.048605|0.062408|0.069310|0.093041|0.123895|0.500000| |1.177394|2.070255|1.243250|2.388598|1.638785|1.254886|1.630804|1.265744|1.238289|1.320793|1.458082|2.767090|1.752114|1.873295|2.167284|2.348264|3.858836|3.290884|5.414177|5.780390|5.624648|4.941703|5.649416|4.088758|7.728317|9.000450|7.911602|8.832795|17.748427|9.021385|16.756212|2.118997|1.841349|2.045511|1.388073|1.873798|0.040175|0.030777|0.033867|0.033614|0.031474|0.032222|0.035886|0.049022|0.063244|0.080786|0.118737|0.107473|0.212305|0.500000| |1.742575|3.229461|2.064022|4.033822|2.825116|2.332082|3.042833|2.552449|2.522129|2.909206|3.592261|7.516472|5.672027|4.970793|5.644687|8.905017|9.954187|4.916400|7.332910|5.671536|3.206962|2.810316|2.344449|2.085995|4.795239|4.151642|4.567284|2.187546|2.358855|2.829925|6.748333|17.696396|8.947697|5.005460|3.005527|3.757273|0.079687|0.044147|0.048840|0.050381|0.052602|0.062070|0.077309|0.107853|0.124124|0.228191|0.121854|0.080919|0.054150|0.060607|0.500000| |1.870059|3.580795|2.329391|4.451934|3.324532|2.878130|3.881472|3.459708|3.549157|4.392797|5.778059|12.989901|8.955191|5.663253|4.948058|5.629414|5.711825|3.309534|5.506946|3.845484|2.354673|2.182426|1.884019|1.743231|4.045640|3.516810|3.887373|1.753914|1.838766|2.109852|4.901362|8.897525|17.737670|7.363414|4.098697|4.689575|0.094350|0.047297|0.051695|0.053583|0.061839|0.084526|0.115536|0.124715|0.107563|0.115467|0.079444|0.063951|0.044376|0.047749|0.215124|0.500000|
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