Version2.4 2021-05-26T09:27:26Z 10.1021/jm300687e Gaussian16 RevisionB.01 CFLINN 26-Dec-2020 #N HF/6-31G(d) OPT=(MaxStep=1) FREQ IOp(6/10=2,6/11=2,6/12=2) DUDE Cc1cc(no1)NS(=O)(=O)c2ccc(cc2)NC(=O)c3ccc(c(c3)Br)OCCC(C)C C14645446 RHF 6-31G(d) (6D,7F) Cc1cc(no1)NS(=O)(=O)c2ccc(cc2)NC(=O)c3ccc(c(c3)Br)OCCC(C)C C01[X(C22H24Br1N3O5S1)] 162 C1 547 CC(CCOc1ccc(cc1Br)C(=O)Nc1ccc(cc1)S(=O)(=O)Nc1noc(c1)C)C CC(CCOc1ccc(cc1Br)C(=O)Nc1ccc(cc1)S(=O)(=O)Nc1noc(c1)C)C CC(C)CCOc1ccc(cc1Br)C(=O)Nc2ccc(cc2)[S](=O)(=O)Nc3cc(C)on3 InChIKey=FVYGUXXYDYEGAT-UHFFFAOYSA-N InChI=1S/C22H24BrN3O5S/c1-14(2)10-11-30-20-9-4-16(13-19(20)23)22(27)24-17-5-7-18(8-6-17)32(28,29)26-21-12-15(3)31-25-21/h4-9,12-14H,10-11H2,1-3H3,(H,24,27)(H,25,26) InChI=1/C22H24BrN3O5S/c1-14(2)10-11-30-20-9-4-16(13-19(20)23)22(27)24-17-5-7-18(8-6-17)32(28,29)26-21-12-15(3)31-25-21/h4-9,12-14H,10-11H2,1-3H3,(H,24,27)(H,25,26)/f/h24,26H Cc1cc(no1)NS(=O)(=O)c2ccc(cc2)NC(=O)c3ccc(c(c3)Br)OCCC(C)C C01[X(C22H24Br1N3O5S1)] 162 C01 547 CC(CCOc1ccc(cc1Br)C(=O)Nc1ccc(cc1)S(=O)(=O)Nc1noc(c1)C)C CC(CCO[C]1[CH][CH][C]([CH][C]1Br)C(=O)N[C]1[CH][CH][C]([CH][CH]1)S(=O)(=O)N[C]1[N]OC(=[CH]1)C)C CC(C)CCO[C]1[CH][CH][C]([CH][C]1Br)C(=O)N[C]2[CH][CH][C]([CH][CH]2)[S](=O)(=O)N[C]3[N]OC(=C3)C InChIKey=FVYGUXXYDYEGAT-UHFFFAOYSA-N InChI=1S/C22H24BrN3O5S/c1-14(2)10-11-30-20-9-4-16(13-19(20)23)22(27)24-17-5-7-18(8-6-17)32(28,29)26-21-12-15(3)31-25-21/h4-9,12-14H,10-11H2,1-3H3,(H,24,27)(H,25,26) InChI=1/C22H24BrN3O5S/c1-14(2)10-11-30-20-9-4-16(13-19(20)23)22(27)24-17-5-7-18(8-6-17)32(28,29)26-21-12-15(3)31-25-21/h4-9,12-14H,10-11H2,1-3H3,(H,24,27)(H,25,26)/f/h24,26H 3619.4454646440 -4352.0262553 1-A 37895.6471 134 413 547 |A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A| -490.07072 -92.21322 -64.48189 -58.62141 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11.07413
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|XX|YY|ZZ|XY|XZ|YZ| 30.7843 -15.6688 -15.1155 35.1909 -49.0499 0.6368
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2.4181 2.9369 1.5673 3.9676 5.4034 4.2608 2.5164 2.4480 2.9017 2.2008 3.1715 1.9760 2.2807 1.7580 2.6779 1.7834 1.2841 1.2823 3.1764 3.3220 2.4256 1.7150 1.2856 2.6571 1.1096 1.5059 6.5542 1.3545 1.4173 2.2314 3.4482 2.1169 1.4638 1.3044 1.2469 1.4373 1.0428 1.1044 1.0636 1.0627 1.0806 1.0641 1.0537 2.5994 1.5885 2.0355 1.6338 2.4825 8.1883 6.5653 3.8776 5.0622 4.4150 7.2059 9.4070 1.0845 1.0369 1.0399 1.0612 1.0595 1.0365 1.1031 1.1025 1.1041 1.1008 1.1027 1.1061 1.1029 1.1040 1.0914 1.0923 1.0898 1.0944 1.0952 1.0930 1.1010 1.0938 1.0783 1.0777 0.0003 0.0003 0.0011 0.0021 0.0016 0.0042 0.0048 0.0082 0.0105 0.0220 0.0255 0.0208 0.0248 0.0489 0.0156 0.0286 0.0646 0.0650 0.0874 0.0675 0.1109 0.1766 0.1531 0.0380 0.1202 0.0646 0.1945 0.2909 0.5629 0.6138 0.1415 0.3479 0.3124 0.5314 0.4766 0.3789 0.2817 0.3995 0.3690 0.4948 0.7561 0.3699 0.4938 0.7472 0.5484 0.3302 0.6466 1.0252 1.1328 1.3191 1.4347 1.9783 2.1642 1.3462 2.3656 1.9365 1.2095 1.4505 1.5442 2.1284 0.7807 0.7517 1.6856 1.0568 1.8909 0.7209 2.3063 0.8803 3.1946 0.7964 4.0895 0.7065 1.1126 0.9759 1.7689 0.9664 0.9274 0.9371 2.8927 2.4528 1.0064 1.0261 3.0607 1.8366 2.2914 1.2779 3.2494 4.4519 3.5992 2.1822 2.1738 2.6522 2.0413 2.9771 1.8970 2.2536 1.7436 2.6661 1.7915 1.3173 1.4263 3.5545 3.8325 2.8382 2.0528 1.5626 3.2734 1.3830 1.8965 8.3866 1.7972 1.9340 3.0457 4.8560 3.0359 2.1004 1.8805 1.8233 2.1413 1.6078 1.7214 1.6680 1.6809 1.7238 1.7080 1.7060 4.2514 2.6033 3.3778 2.7389 4.2987 14.5244 11.9163 7.3143 9.6493 8.4767 14.5537 21.3029 6.4363 6.2388 6.2755 6.4526 6.4574 6.3489 6.8494 6.8838 6.9221 6.9147 6.9407 7.0054 7.0294 7.1430 7.2505 7.4238 7.4546 7.5098 7.5595 7.5724 7.7621 7.7842 9.4068 9.6333 0.8903 0.7159 1.2205 0.4815 0.2605 2.1945 1.9232 3.6231 0.3794 4.3000 1.8161 0.3856 0.9729 2.4853 1.2383 2.1143 2.1266 2.9105 2.3975 0.4663 0.8004 2.4640 1.3413 0.0746 0.8070 0.4834 5.6736 0.2513 3.9792 14.4743 30.3137 14.3359 9.3568 10.8123 17.3868 5.2568 0.5393 11.5072 0.8969 6.0337 4.6701 1.1252 1.3862 6.5074 1.4192 66.3137 13.4362 22.4658 85.2356 130.1243 0.1963 25.6321 88.9164 29.7946 84.8104 21.0978 33.6130 15.7501 6.0557 44.0209 10.5244 96.9091 36.3799 8.3600 6.0394 28.6070 0.6885 61.5257 269.5888 38.2047 23.9265 1.5939 5.5309 0.7016 48.5246 5.2498 0.6841 0.7852 3.3815 6.0555 1.4207 2.1201 23.3188 8.0031 4.8059 4.7671 163.5152 44.9417 58.5372 28.9047 28.3358 27.6285 2.6207 368.1874 188.0400 37.3169 9.3208 69.8244 1.2025 14.4236 19.8347 24.1858 218.4960 721.2524 77.0288 4.0071 292.0159 1.2540 74.2098 108.1615 2.0027 1.8498 84.0219 39.0761 133.4891 28.4295 16.0315 8.3848 52.6282 6.2075 7.3885 0.1724 3.6129 2.6530 1.0658 19.1130 357.1942 308.4123 41.6151 257.7086 412.6658 15.6056 5.2548 286.6331 216.1820 15.2326 149.1656 301.5473 19.4398 34.0604 17.5072 10.7151 41.9869 15.1954 4.1737 8.1419 19.2081 86.5752 89.5977 80.2875 9.8503 14.0810 18.6655 6.1966 3.9688 0.9109 7.6795 0.6433 0.5023 3.9921 108.4519 30.8590 1.9291 1.0870 1.2548 0.7311 0.6068 1.7473 4.0107 1.9091 1.7883 0.6625 1.2145 0.3324 0.6809 0.8975 0.5735 0.2455 1.1533 1.7534 0.4424 1.5385 1.5485 0.8714 0.2734 0.0430 0.4762 0.4830 1.9757 2.4003 3.7318 3.3552 3.7638 1.6679 6.0820 0.9687 1.5407 1.3910 1.4382 6.4962 0.3812 1.8991 1.2903 0.7885 0.1897 1.1543 2.1057 1.7200 1.4215 0.4131 2.1500 1.1022 2.6740 5.6009 11.5942 5.5525 7.6057 1.8088 1.3238 0.8237 0.2982 6.5452 1.5908 1.3562 5.2102 0.3824 37.0626 2.4888 3.4474 3.3428 15.5852 0.9623 13.1028 0.8379 10.5846 7.6950 3.2876 1.5648 2.5035 0.8814 2.8773 7.9214 2.5175 1.3130 4.0228 11.8971 6.3569 0.2561 2.1916 8.9509 30.6768 12.2910 3.3620 12.2302 7.3326 57.4549 36.8230 11.5872 5.5516 7.3685 2.8031 14.2332 2.0200 4.9554 24.0040 193.1478 6.5147 4.9758 11.6476 19.2032 19.8741 3.9323 6.5178 9.7288 4.3269 4.5353 5.8052 4.1151 6.5528 2.9536 4.7268 18.7147 22.5945 7.8512 26.2794 9.2385 24.2729 2.0488 4.7863 13.5094 16.6220 5.1154 69.7635 54.6775 8.4189 103.8129 459.7985 10.0930 0.1271 167.9944 79.7145 3.0479 122.7364 181.5469 18.3979 162.8731 36.3102 16.9653 36.6696 112.0276 147.7142 9.4486 89.8780 73.9729 70.4315 48.2808 51.7468 73.0308 126.9677 55.7335 65.9627 50.3930 68.1037 74.5649 0.7487 0.7406 0.7171 0.7321 0.7442 0.7438 0.7500 0.7378 0.7429 0.7337 0.7490 0.6919 0.4077 0.4794 0.5279 0.2682 0.2419 0.7342 0.6480 0.7495 0.7404 0.3856 0.7484 0.7418 0.5442 0.7275 0.5287 0.2066 0.2596 0.6027 0.2496 0.7495 0.5122 0.5764 0.2989 0.2286 0.1037 0.4489 0.7310 0.6679 0.3702 0.4774 0.6858 0.7209 0.3166 0.7401 0.6816 0.4964 0.2862 0.3471 0.7500 0.7234 0.4327 0.4331 0.1110 0.4348 0.6383 0.3885 0.1868 0.5622 0.7477 0.4947 0.0968 0.6731 0.0805 0.7326 0.2869 0.3326 0.2409 0.5528 0.1003 0.6429 0.6283 0.7055 0.1751 0.6947 0.5890 0.7364 0.7444 0.2106 0.3755 0.5755 0.7204 0.1409 0.4164 0.7327 0.4162 0.4352 0.3338 0.1803 0.2812 0.2576 0.5973 0.1872 0.1892 0.6425 0.6835 0.1851 0.3367 0.2358 0.2770 0.7188 0.5627 0.2934 0.3368 0.4921 0.2521 0.7460 0.3724 0.5274 0.7411 0.6950 0.5301 0.2003 0.5213 0.6282 0.7326 0.7497 0.7438 0.7469 0.7001 0.7141 0.7195 0.6759 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0.6596 0.4026 0.8545 0.5427 0.6906 0.8513 0.8201 0.6929 0.3338 0.6853 0.7717 0.8457 0.8570 0.8531 0.8551 0.8236 0.8332 0.8369 0.8066 0.8495 0.7522 0.8505 0.6216 0.5670 0.5390 0.5900 0.3961 0.2266 0.6054 0.6106 0.8366 0.7845 0.4214 0.6887 0.2210 0.0475 0.0997 0.1065 0.0407 0.7381 0.8557 0.8266 0.6637 0.8310 0.8331 0.8543 0.8544 0.5097 0.4107 0.8395 0.3522 0.2644 0.4919 0.4548 0.3167 0.3684 0.3011
298.150 1.00000 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 6 6 6 6 7 8 7 16 8 8 6 6 6 6 6 6 7 6 8 6 6 6 6 6 6 35 8 6 6 6 6 6 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 12.00000 12.00000 12.00000 12.00000 14.00307 15.99491 14.00307 31.97207 15.99491 15.99491 12.00000 12.00000 12.00000 12.00000 12.00000 12.00000 14.00307 12.00000 15.99491 12.00000 12.00000 12.00000 12.00000 12.00000 12.00000 78.91834 15.99491 12.00000 12.00000 12.00000 12.00000 12.00000 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783
7069.7746 66582.8075 66669.8548 0.99989 0.00686 -0.01286 -0.00237 0.94722 0.32058 0.01438 -0.32051 0.94714 1 0.01225 0.00130 0.00130 0.25528 0.02711 0.02707 11.02 13.19 26.85 37.02 43.55 52.80 61.89 66.70 80.52 102.32 135.05 148.41 164.72 176.33 185.42 198.97 214.52 220.36 245.53 256.99 296.89 310.66 332.10 351.30 377.52 401.18 429.25 446.54 467.28 487.89 498.15 508.16 529.64 558.11 573.80 599.18 622.98 632.34 654.88 666.77 690.51 707.89 722.12 733.94 807.22 838.82 870.65 895.34 915.85 933.78 983.81 990.13 1010.71 1034.76 1077.27 1117.44 1137.72 1149.12 1171.46 1228.93 1236.01 1248.40 1264.57 1274.60 1308.24 1330.15 1339.81 1370.55 1378.81 1389.09 1436.21 1455.44 1487.83 1507.31 1514.94 1519.71 1557.45 1568.31 1591.49 1594.81 1605.12 1615.06 1631.74 1633.58 1655.70 1692.55 1696.32 1701.41 1722.76 1745.54 1766.30 1792.05 1805.23 1816.09 1836.56 1863.22 1866.76 1870.32 1878.65 1898.50 1976.85 1982.86 2013.30 2027.59 2050.75 2066.56 2080.49 2092.60 2103.48 2120.31 2159.12 2189.63 2189.89 2224.39 2244.71 2245.34 2250.62 2266.57 2287.88 2327.42 2340.12 2347.32 2357.46 2367.52 2374.78 2385.07 2397.17 2399.63 2414.61 2426.95 2466.59 2496.44 2525.29 2574.38 2587.91 2597.26 2663.85 2820.73 4566.42 4597.71 4604.70 4622.11 4627.46 4639.08 4670.65 4683.79 4693.26 4697.81 4702.69 4717.24 4732.12 4767.79 4831.25 4886.63 4902.30 4910.20 4924.52 4933.65 4976.94 5000.41 5536.34 5604.10 0.471766 0.501702 0.502646 0.403434 -4351.554489 -4351.524553 -4351.523609 -4351.622822 3.327620D-04
MUNgauss RevisionA2.1 retrievium 26-May-2021 DUDE Cc1cc(no1)NS(=O)(=O)c2ccc(cc2)NC(=O)c3ccc(c(c3)Br)OCCC(C)C C14645446 RHF 6-31G(d) (6D,10F) C1 521.062004 |X|Y|Z| 45.865017 43.747203 184.061979
71.746157 21 6 7 8 16 16 3 1 1
|36.858105| |12.788515|36.858105| |7.330768|14.183179|36.858105| |5.223809|8.805588|13.326958|36.858105| |5.298882|8.636432|8.466394|14.862018|53.358707| |7.948968|14.431145|8.729934|9.022825|18.894895|73.516695| |3.835472|5.432239|7.631861|13.771694|11.078518|9.811908|53.358707| |3.009320|3.929310|4.730522|6.996721|8.302889|7.611627|15.580002|388.023441| |2.599061|3.243945|3.941146|5.096247|5.874779|5.955814|10.768477|94.640386|73.516695| |3.016438|3.880910|4.402016|6.187183|8.254229|7.778570|10.255618|95.161152|13.628570|73.516695| |2.757094|3.495574|3.911801|5.479413|7.564110|7.097399|9.517335|77.106887|13.015555|13.072248|36.858105| |2.444323|2.996830|3.361749|4.338986|5.742670|5.837923|7.455169|49.793838|11.489867|8.854289|13.724234|36.858105| |2.227312|2.651565|2.861686|3.524132|4.879684|5.206500|5.530043|33.866585|7.864868|6.847377|7.984489|13.848542|36.858105| |2.231337|2.631507|2.738136|3.356002|4.928315|5.331793|4.951475|29.931296|6.557392|6.565380|6.879273|7.906443|13.633222|36.858105| |2.461184|2.949481|3.011540|3.806728|5.937933|6.236460|5.436158|33.691993|6.808791|7.836439|7.931327|6.834192|7.900618|13.686323|36.858105| |2.767310|3.455165|3.620500|4.921053|7.772757|7.435906|7.264396|49.618626|8.817191|11.458840|13.758035|7.916138|6.891386|7.945762|13.769117|36.858105| |1.988795|2.277809|2.331936|2.741289|4.008753|4.548364|3.942350|22.869196|5.206181|5.180484|4.571402|5.213104|8.008365|13.603267|7.731306|5.138265|53.358707| |1.876861|2.110952|2.116095|2.442868|3.635376|4.239287|3.418894|19.594410|4.439148|4.622533|3.679988|3.895601|5.156238|7.628147|6.268822|4.313832|18.935238|36.858105| |1.926526|2.163418|2.138336|2.476043|3.770843|4.417762|3.407906|19.653554|4.360974|4.785618|3.633480|3.615942|4.458982|6.543898|6.606199|4.511756|11.451854|15.905705|73.516695| |1.674640|1.848661|1.851175|2.084483|3.048558|3.639321|2.909358|16.333929|3.798779|3.855666|2.912872|3.137555|4.000333|5.036584|4.222846|3.240519|10.704800|12.722302|14.402726|36.858105| |1.539676|1.679992|1.670238|1.861469|2.727493|3.299199|2.579318|14.494287|3.383037|3.493454|2.501759|2.625363|3.183230|3.873235|3.497220|2.792028|7.125749|7.716376|12.072060|13.741555|36.858105| |1.404643|1.516036|1.507788|1.657052|2.402441|2.940068|2.293457|12.738356|3.012647|3.068355|2.142958|2.260172|2.680078|3.097656|2.809463|2.335074|5.399186|5.070498|8.109974|7.902086|13.787202|36.858105| |1.375719|1.480891|1.480003|1.615374|2.317231|2.843435|2.242760|12.314195|2.941220|2.929156|2.060655|2.211925|2.628727|2.941191|2.606272|2.197648|5.106583|4.428630|6.781475|6.789654|7.910237|13.689603|36.858105| 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|17.574214|8.976819|5.817607|4.563176|6.559474|12.568933|4.705602|20.163583|4.350915|5.231657|2.586748|2.274570|2.082616|2.108370|2.349475|2.638968|2.569397|1.801164|3.319985|1.608196|1.492334|1.362189|1.326381|1.407973|1.551661|45.308964|2.174108|1.152093|1.070654|1.001756|1.006813|0.940031|0.301657|0.500000| |17.611613|8.965039|6.842248|4.661759|5.987630|10.268663|4.912158|20.029177|4.454288|4.947292|2.544532|2.298601|2.088717|2.061560|2.233236|2.498350|2.515720|1.737536|3.143399|1.565192|1.440821|1.323301|1.303255|1.395355|1.533751|45.595987|2.143907|1.129936|1.055762|0.984552|0.984126|0.928326|0.300059|0.300093|0.500000| |6.262745|8.740573|17.823503|8.443968|7.913224|10.512826|8.922197|30.052953|6.723687|6.870488|3.457748|3.089830|2.636392|2.479006|2.657423|3.129886|2.912579|1.939999|3.454410|1.720129|1.556702|1.417091|1.399463|1.516901|1.690369|49.553285|2.284938|1.193492|1.110616|1.029473|1.017910|0.969294|0.140186|0.140494|0.187170|0.500000| |3.610262|4.868524|7.105436|9.315337|8.082004|8.164642|25.987353|60.763046|14.213643|10.692196|5.530623|4.825548|3.650584|3.202093|3.385371|4.272654|3.566514|2.279468|4.001049|1.976695|1.760559|1.581898|1.558036|1.704231|1.932341|55.081282|2.516633|1.304710|1.204619|1.110620|1.087661|1.040918|0.089917|0.090018|0.098164|0.195706|0.500000| |2.356035|2.866061|3.300014|4.130622|5.174944|5.388195|7.430528|47.456403|13.171621|8.174650|8.900914|17.755195|8.947193|5.631192|4.934921|5.638267|5.752588|3.280594|5.396778|2.767222|2.351205|2.068101|2.049986|2.311991|2.727269|73.460296|3.233890|1.637584|1.488856|1.348572|1.297648|1.251900|0.063360|0.060644|0.062602|0.086843|0.143592|0.500000| |2.037560|2.379716|2.569113|3.052969|4.148319|4.570656|4.754732|27.972459|6.894100|5.749148|5.669095|8.975663|17.704450|8.872991|5.625845|4.960562|10.056741|4.837365|7.131674|4.043759|3.185427|2.737773|2.753731|3.261828|4.105447|100.585792|4.201484|2.059789|1.836775|1.625528|1.545816|1.490289|0.056522|0.052869|0.053682|0.067034|0.090420|0.216349|0.500000| |2.385613|2.797453|2.773169|3.400481|5.442809|5.982900|4.660740|27.875761|5.726706|6.869890|5.655454|4.941642|5.632067|8.900387|17.844205|8.945363|9.520237|6.843652|15.152208|4.468425|3.809067|2.992263|2.703485|2.919489|3.656442|81.591495|4.043941|2.075207|1.796379|1.627211|1.613744|1.457705|0.066812|0.064068|0.059723|0.067940|0.081707|0.107385|0.123820|0.500000| 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