Version2.2 2021-02-11T23:59:08Z 10.1021/jm300687e Gaussian16 RevisionB.01 SBUNGAY 27-Nov-2020 #N HF/6-31G(d) OPT=(MaxStep=1) FREQ IOp(6/10=2,6/11=2,6/12=2) DUDE Cc1ccccc1N2[C@H](N=C([C@@H](C2=O)[C@@H]3[C@@H]4C(=c5ccccc5=[NH+]4)CCN3)O)O C64019299 RHF 6-31G(d) (6D,7F) Cc1ccccc1N2[C@H](N=C([C@@H](C2=O)[C@@H]3[C@@H]4C(=c5ccccc5=[NH+]4)CCN3)O)O C01[X(C22H23N4O3)] 150 C1 481 OC1=N[C@H](O)N(C(=O)[C@H]1[C@H]1NCCC2=c3c(=[NH+][C@H]12)cccc3)c1ccccc1C OC1=N[C@H](O)N(C(=O)[C@H]1[C@H]1NCCC2=c3c(=[NH+][C@H]12)cccc3)c1ccccc1C Cc1ccccc1N2[C@@H](O)N=C(O)[C@H]([C@H]3NCCC4=C5C=CC=CC5=[NH+][C@H]34)C2=O InChIKey=HVQNJLVRSHSWIC-VWNVYAMZSA-O InChI=1S/C22H22N4O3/c1-12-6-2-5-9-16(12)26-21(28)17(20(27)25-22(26)29)19-18-14(10-11-23-19)13-7-3-4-8-15(13)24-18/h2-9,17-19,22-23,29H,10-11H2,1H3,(H,25,27)/p+1/t17-,18-,19+,22-/m0/s1 InChI=1/C22H22N4O3/c1-12-6-2-5-9-16(12)26-21(28)17(20(27)25-22(26)29)19-18-14(10-11-23-19)13-7-3-4-8-15(13)24-18/h2-9,17-19,22-23,29H,10-11H2,1H3,(H,25,27)/p+1/t17-,18-,19+,22-/m0/s1/fC22H23N4O3/h24,27H/q+1 Cc1ccccc1N2[C@H](N=C([C@@H](C2=O)[C@@H]3[C@@H]4C(=c5ccccc5=[NH+]4)CCN3)O)O C01[X(C22H23N4O3)] 150 C01 481 OC1=N[C@H](O)N(C(=O)[C@H]1[C@H]1NCCC2=c3c(=[NH+][C@H]12)cccc3)c1ccccc1C OC1=N[C@H](O)N(C(=O)[C@H]1[C@H]1NCCC2=[C]3[C]([NH][C@H]12)[CH]=[CH][CH]=[CH]3)[C]1[CH][CH][CH][CH][C]1C C[C]1[CH][CH][CH][CH][C]1N2[C@@H](O)N=C(O)[C@H]([C@H]3NCCC4=C5C=CC=C[C]5N[C@H]34)C2=O InChIKey=NHDSXILQXBUPDC-VWNVYAMZSA-N InChI=1S/C22H23N4O3/c1-12-6-2-5-9-16(12)26-21(28)17(20(27)25-22(26)29)19-18-14(10-11-23-19)13-7-3-4-8-15(13)24-18/h2-9,17-19,22-24,29H,10-11H2,1H3,(H,25,27)/t17-,18-,19+,22-/m0/s1 InChI=1/C22H23N4O3/c1-12-6-2-5-9-16(12)26-21(28)17(20(27)25-22(26)29)19-18-14(10-11-23-19)13-7-3-4-8-15(13)24-18/h2-9,17-19,22-24,29H,10-11H2,1H3,(H,25,27)/t17-,18-,19+,22-/m0/s1/f/h27H 2788.5287347827 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4914.2321 21313.7357 21466.5957 0.99999 -0.00223 -0.00248 0.00300 0.92435 0.38153 0.00145 -0.38154 0.92435 1 0.01763 0.00406 0.00403 0.36725 0.08468 0.08407 30.74 33.61 56.33 69.29 92.82 113.48 155.32 162.91 177.82 208.74 210.30 240.81 249.27 286.88 313.55 349.76 373.67 395.12 439.60 453.27 493.52 533.05 553.39 589.99 619.19 630.32 673.48 687.84 724.35 738.04 745.02 768.32 796.29 806.86 824.22 832.19 847.85 853.04 876.72 892.21 945.51 983.89 1004.31 1033.24 1047.27 1056.85 1104.45 1161.52 1181.88 1191.90 1222.77 1231.27 1245.07 1261.11 1267.48 1339.82 1363.54 1369.03 1374.44 1398.20 1419.25 1431.99 1506.00 1525.61 1541.30 1551.08 1577.42 1590.62 1611.81 1622.36 1646.02 1657.95 1664.90 1678.85 1692.76 1697.11 1710.48 1730.14 1743.12 1755.56 1770.67 1784.45 1820.60 1827.06 1842.85 1859.79 1890.42 1902.32 1915.56 1936.30 1937.74 1966.61 1977.28 1995.60 2017.94 2040.52 2053.22 2060.55 2077.71 2105.67 2110.42 2132.34 2168.12 2191.88 2202.33 2220.40 2228.34 2255.99 2260.08 2267.72 2296.60 2309.25 2320.21 2353.30 2353.67 2367.87 2376.46 2385.22 2400.14 2407.93 2505.09 2531.31 2561.67 2603.51 2649.95 2780.88 2825.37 4572.68 4607.40 4630.22 4631.49 4652.60 4722.63 4747.20 4750.05 4756.11 4762.54 4791.40 4837.15 4846.21 4865.95 4876.34 4886.42 4893.11 4904.27 4918.69 5450.89 5575.41 5792.58 5876.26 0.461141 0.483835 0.484780 0.407649 -1288.227458 -1288.204763 -1288.203819 -1288.280950 2.586986D-04
MUNgauss RevisionA2.1 retrievium 11-Feb-2021 DUDE Cc1ccccc1N2[C@H](N=C([C@@H](C2=O)[C@@H]3[C@@H]4C(=c5ccccc5=[NH+]4)CCN3)O)O C64019299 RHF 6-31G(d) (6D,10F) C1 391.177016 |X|Y|Z| 37.949511 39.205674 101.037760
53.171585 25 6 7 21 4
|36.858105| |12.618189|36.858105| |7.567881|13.699735|36.858105| |5.010358|7.859453|13.761243|36.858105| |4.410832|6.780656|7.943256|13.767015|36.858105| |4.990138|7.866209|6.924421|7.985692|13.775697|36.858105| |7.491411|13.678733|8.014715|6.906949|7.929628|13.750428|36.858105| |6.469582|7.719016|5.128000|4.537228|5.150309|7.877575|13.213902|53.358707| |5.047459|5.558818|4.135313|3.793876|4.296213|6.002224|7.694213|17.944643|36.858105| |4.539983|5.391616|4.259225|4.099709|4.832994|6.788792|7.576154|12.714482|17.685845|0.500000| |3.794641|4.012113|3.202869|3.038338|3.460567|4.574499|5.188090|10.736253|13.248652|0.258763|53.358707| |3.639280|3.702163|2.962939|2.782810|3.113509|4.020148|4.616215|9.542629|8.266554|0.168771|20.816945|36.858105| |4.291031|4.160011|3.223199|2.926670|3.182956|4.083366|5.014673|10.611948|6.876821|0.140677|10.630723|12.583612|36.858105| |4.546962|4.081957|3.149026|2.786085|2.933914|3.645724|4.588256|9.137420|6.357636|0.130033|9.104965|9.119233|17.490052|0.500000| |5.760254|5.975339|4.272570|3.783111|4.149758|5.681439|7.875961|19.267563|7.823002|0.162762|9.159041|7.639289|12.378176|0.252061|36.858105| |5.652894|5.833554|4.361367|3.844309|4.101001|5.275464|6.884839|11.503451|5.354107|0.124075|6.478462|5.350248|8.020703|0.184052|15.886399|73.516695| |3.481251|3.378450|2.763423|2.557310|2.758574|3.375467|3.886936|6.984246|4.481397|0.102174|6.889429|7.244341|12.377801|0.246574|7.609496|12.565047|36.858105| |3.719225|3.495873|2.859896|2.598522|2.736622|3.281767|3.852206|6.586228|4.035345|0.093328|5.739869|5.459356|9.048600|0.220236|7.304483|14.175041|17.530709|0.500000| |2.843236|2.711331|2.286793|2.131799|2.272470|2.689749|3.017292|5.165861|3.624323|0.085067|5.778097|5.865484|7.327798|0.188674|4.861850|8.049893|12.284854|0.247603|36.858105| |2.647575|2.570445|2.183120|2.060660|2.221914|2.636987|2.904072|4.994427|3.685436|0.087265|6.246464|6.481134|6.715213|0.168951|4.450465|7.078121|8.768571|0.174289|17.626850|0.500000| |2.456937|2.366199|2.052324|1.936168|2.053275|2.369556|2.588140|4.195481|2.890964|0.070400|4.441929|4.144394|4.911765|0.126874|3.835132|6.829191|7.705595|0.195484|12.737335|0.248902|36.858105| |2.309873|2.176032|1.904940|1.782290|1.857486|2.106702|2.314801|3.671320|2.548432|0.062497|3.809878|3.419026|4.025550|0.111439|3.272841|5.894656|5.548318|0.157420|8.174036|0.174270|14.033102|36.858105| |2.025343|1.914386|1.708937|1.608578|1.663833|1.851948|2.007532|3.090403|2.145455|0.053624|3.148726|2.721824|3.112696|0.086351|2.679870|4.914916|4.000327|0.116293|5.069262|0.120045|7.425359|13.224819|36.858105| |1.924164|1.795090|1.611711|1.508846|1.544058|1.702822|1.853105|2.823287|1.976504|0.049600|2.862738|2.427793|2.751223|0.078492|2.404626|4.390774|3.341715|0.098263|4.093938|0.099582|5.135309|7.962458|14.187166|36.858105| |2.030664|1.859456|1.657280|1.535126|1.560753|1.725485|1.902925|2.919056|2.064309|0.051420|2.975554|2.517947|2.863989|0.084642|2.473532|4.448654|3.357211|0.099025|4.145040|0.100807|4.654920|6.896920|7.873870|13.193013|36.858105| |2.292675|2.074141|1.818003|1.669656|1.701270|1.904832|2.132444|3.343011|2.379796|0.058322|3.455648|2.977020|3.443911|0.105104|2.865186|5.052718|4.012011|0.117632|5.187646|0.122908|5.302505|7.672873|6.615303|7.709239|14.040614|36.858105| |2.493432|2.286386|1.976616|1.821678|1.881411|2.142340|2.404542|3.868322|2.729420|0.065933|4.059065|3.650384|4.358198|0.130018|3.430044|6.003973|5.538303|0.158641|8.336777|0.177098|8.449989|13.228006|7.647277|6.813219|8.074984|13.465291|36.858105| |2.841338|2.600828|2.197363|2.013787|2.098326|2.441038|2.786992|4.675498|3.337183|0.078369|5.092582|4.826513|5.982756|0.185524|4.242441|7.076240|7.525203|0.197847|13.126148|0.252793|8.303407|8.430752|5.287495|4.649051|5.251035|7.710049|14.441755|53.358707| |2.974938|2.675111|2.242569|2.037348|2.111287|2.459609|2.844769|4.817781|3.548868|0.082394|5.395149|5.023032|6.010140|0.207072|4.238416|6.826199|6.348332|0.166395|8.765836|0.208318|5.845965|5.928135|4.239606|3.954564|4.649303|6.834410|9.296083|26.026677|0.500000| |2.300431|2.286145|2.014044|1.938432|2.084574|2.394248|2.536569|4.020556|2.736339|0.068150|4.195586|3.806799|4.311289|0.105655|3.616246|6.594406|6.435870|0.161250|7.437372|0.182670|12.803971|7.327588|5.709930|4.095246|3.569924|3.796945|5.113757|7.001155|0.114467|36.858105| |2.628946|2.671349|2.333848|2.255125|2.456575|2.866643|3.026604|4.799409|3.107590|0.077189|4.661444|4.222296|5.035147|0.115979|4.498788|8.605043|7.840047|0.199379|6.549607|0.157423|7.801571|5.283738|4.274961|3.337856|3.039871|3.282988|4.259052|6.230362|0.106515|12.370084|36.858105| |3.060004|3.141050|2.652567|2.544694|2.822663|3.445474|3.717328|6.329767|4.047480|0.097257|6.304040|6.159311|7.701385|0.155993|6.318557|11.132590|13.139691|0.250566|7.925276|0.196704|6.909803|4.755701|3.681994|3.014894|2.895414|3.267863|4.282313|6.962203|0.122754|7.791756|13.116413|53.358707| |2.921080|2.945485|2.460098|2.348941|2.608729|3.217369|3.514941|6.435998|5.374192|0.124163|11.598841|14.323603|7.912340|0.182467|5.200965|7.376637|6.575127|0.134772|6.533794|0.240734|4.568945|3.679982|2.896381|2.553042|2.625780|3.099220|3.865341|6.943004|0.143917|4.179953|4.297859|8.142519|73.516695| |5.516855|5.296427|3.955799|3.454899|3.638697|4.605092|6.045869|11.294108|13.671991|0.259864|11.199183|6.364033|5.876220|0.178312|6.160004|8.149514|3.990684|0.103765|3.406909|0.094975|2.717178|2.476698|2.096181|1.969125|2.101169|2.449253|2.740853|4.556835|0.102922|2.494676|2.743032|4.664709|8.174748|73.516695| |17.552413|8.878245|6.054213|4.363813|3.966955|4.522534|6.488231|8.355030|4.593672|0.111590|4.984603|3.692829|4.651799|0.137515|6.346341|12.226575|3.906648|0.121454|3.120210|0.078626|2.710076|2.556410|2.231569|2.112800|2.227154|2.520224|2.758336|4.260888|0.089783|2.517374|2.908962|4.572530|5.311012|8.595813|0.500000| |17.598476|8.839711|5.771078|4.240638|3.940608|4.604254|6.801387|9.322253|5.893206|0.140978|5.838639|4.040896|4.671639|0.144673|5.878371|9.309148|3.604865|0.104430|2.994983|0.078272|2.522745|2.374783|2.059527|1.963213|2.098415|2.406140|2.616627|4.141218|0.090827|2.321780|2.605900|4.197427|5.669817|13.089630|0.301045|0.500000| |17.592537|8.889385|7.303742|4.775811|3.971894|4.176832|5.572970|6.493555|4.026575|0.104685|4.304841|3.031893|3.471052|0.102589|4.347299|7.778285|2.937766|0.087350|2.482361|0.064497|2.189918|2.092060|1.865966|1.794020|1.897203|2.117204|2.255654|3.423928|0.073162|2.056496|2.314354|3.568885|4.476759|7.943313|0.301988|0.301654|0.500000| |7.059470|8.944813|17.718653|8.949719|5.656721|4.978784|5.680847|5.648688|3.492437|0.098427|3.797847|2.618765|2.862884|0.079375|3.637386|6.693066|2.504592|0.072861|2.114746|0.055859|1.916478|1.804970|1.635085|1.557070|1.607526|1.754311|1.881127|2.812605|0.058731|1.868907|2.135325|3.241862|3.939290|6.208005|0.159499|0.148806|0.225762|0.500000| |4.097156|5.618977|8.932744|17.722831|8.915825|5.663629|4.970115|4.916936|3.141447|0.094016|3.544245|2.407138|2.514956|0.067018|3.128535|5.703518|2.246832|0.063580|1.909140|0.051362|1.756979|1.630631|1.487901|1.402798|1.423887|1.535823|1.660647|2.469529|0.050896|1.765589|2.031790|3.059640|3.692580|5.196804|0.101514|0.098210|0.113904|0.216488|0.500000| |3.532160|4.904916|5.642580|8.894905|17.730696|8.921036|5.643110|5.695131|3.677741|0.115887|4.240149|2.816692|2.820464|0.071959|3.514479|6.194637|2.504078|0.068460|2.099083|0.057497|1.921481|1.737745|1.568952|1.454960|1.461533|1.581123|1.744322|2.625648|0.053658|1.975671|2.313955|3.561584|4.307299|5.560750|0.090373|0.089832|0.090447|0.124240|0.214029|0.500000| |4.078244|5.623853|4.978121|5.660605|8.910302|17.708579|8.946120|9.966050|6.099597|0.197016|6.855933|4.365916|4.201687|0.100741|5.534353|8.847945|3.500286|0.091556|2.794060|0.077452|2.458835|2.151536|1.883407|1.716752|1.727844|1.905859|2.164896|3.371669|0.068863|2.525243|3.040327|5.058559|6.260998|7.819388|0.106261|0.109006|0.096116|0.107952|0.124205|0.214617|0.500000| |1.906129|1.827688|1.646920|1.565205|1.625588|1.799321|1.924326|2.929236|2.025292|0.051131|2.969774|2.542802|2.866116|0.077786|2.522113|4.669341|3.672469|0.105675|4.423166|0.108151|6.562148|8.718215|17.745994|9.019756|5.590692|4.818948|5.499977|5.834760|0.098228|5.997096|4.382786|4.878547|4.816312|3.475259|0.058110|0.053386|0.048906|0.043714|0.040372|0.042869|0.051082|0.500000| |1.758452|1.648557|1.496425|1.407511|1.435958|1.568547|1.692949|2.543791|1.782471|0.045173|2.563673|2.140862|2.392751|0.067895|2.137353|3.921428|2.843506|0.083405|3.349886|0.083593|4.102166|5.629762|9.039047|17.757161|8.775851|5.585662|4.926407|5.014961|0.090016|3.518495|2.934163|3.584508|3.985783|3.156271|0.053362|0.049560|0.045939|0.040343|0.036577|0.037769|0.043879|0.215347|0.500000| |1.900393|1.734185|1.558752|1.443412|1.458092|1.597873|1.757389|2.663104|1.893332|0.047529|2.702198|2.245819|2.518634|0.074812|2.218918|3.988741|2.856820|0.084113|3.393699|0.084739|3.687044|4.965675|5.659533|8.807433|17.722096|9.089574|5.703270|5.709986|0.108665|2.975235|2.601536|3.400467|4.132869|3.457937|0.057520|0.054526|0.049880|0.042299|0.037390|0.038001|0.044259|0.124064|0.215720|0.500000| |2.339609|2.085420|1.824710|1.664026|1.684328|1.881697|2.122290|3.322602|2.396947|0.058671|3.446660|2.922595|3.340478|0.105300|2.798076|4.865572|3.670876|0.106993|4.534888|0.111225|4.300556|5.502493|4.819609|5.522947|8.945910|17.752300|8.756746|9.226699|0.193127|3.229712|2.896973|4.042699|5.336959|4.492713|0.070885|0.069091|0.060391|0.049166|0.042537|0.043348|0.051972|0.105284|0.123180|0.216886|0.500000| |2.161958|2.172920|1.923326|1.869944|2.030645|2.335005|2.437160|3.872344|2.709738|0.068142|4.270024|3.857204|4.067457|0.099035|3.376089|5.952639|5.589651|0.132456|6.629538|0.189532|9.052284|5.851955|4.748264|3.590887|3.197585|3.410362|4.453893|6.293799|0.106834|17.550125|8.854804|9.518466|7.952927|4.353567|0.064582|0.061094|0.053805|0.049422|0.047402|0.053912|0.069443|0.138275|0.087357|0.075399|0.082392|0.500000| |2.101506|2.083850|1.864363|1.800096|1.918588|2.162998|2.273476|3.508031|2.385489|0.060221|3.577235|3.135918|3.520448|0.088863|3.088098|5.747750|4.877163|0.131391|5.473262|0.136220|8.903913|6.810463|6.271352|4.354409|3.582821|3.613093|4.596266|5.864371|0.098116|17.608589|8.736365|7.649753|6.012336|3.916324|0.063907|0.058435|0.052868|0.048486|0.045978|0.050825|0.062856|0.207397|0.106611|0.083457|0.084658|0.300597|0.500000| |2.426598|2.523750|2.248616|2.218211|2.445876|2.820766|2.877503|4.430570|2.891280|0.073634|4.318538|3.760267|4.205832|0.097641|3.958991|7.546909|5.694439|0.145613|4.917231|0.127543|5.644567|4.188708|3.618487|2.903197|2.633263|2.787250|3.460490|4.992321|0.088457|8.860069|17.620352|12.531087|6.836731|4.484614|0.073451|0.066310|0.059861|0.057007|0.055896|0.065057|0.084429|0.106239|0.072776|0.063827|0.069338|0.218602|0.208038|0.500000| |2.731082|2.739119|2.402601|2.296980|2.458022|2.827739|3.025172|4.677636|2.949322|0.073314|4.249744|3.752446|4.682921|0.112050|4.441157|9.118952|7.047426|0.214485|5.718012|0.131110|6.875910|5.240895|4.405945|3.472499|3.141793|3.346503|4.246805|5.987246|0.102724|8.812563|17.479267|12.218084|6.523312|4.717060|0.085833|0.073960|0.067077|0.061563|0.057636|0.063873|0.081246|0.125491|0.085140|0.074807|0.081744|0.173826|0.215419|0.301568|0.500000| |3.323323|3.539447|2.974151|2.882112|3.262387|4.076930|4.334487|7.296365|4.380361|0.106498|6.515710|5.972026|7.407740|0.147704|7.389631|13.622061|9.459787|0.215291|5.793745|0.148181|5.135677|3.884575|3.156099|2.660343|2.574074|2.873713|3.603503|5.754065|0.105971|5.753247|9.484994|25.907608|9.430065|6.348169|0.101147|0.091185|0.078189|0.072898|0.069869|0.083492|0.123759|0.086076|0.065657|0.062795|0.073927|0.147320|0.127414|0.230151|0.218089|0.500000| |2.709492|2.769645|2.349825|2.272363|2.539752|3.102676|3.303176|5.846158|5.159334|0.125291|11.463395|10.235637|5.919888|0.144246|4.410972|6.362953|4.970889|0.108825|4.980746|0.176206|3.791564|3.158509|2.570764|2.298457|2.362004|2.741697|3.299580|5.648547|0.118923|3.576694|3.649579|6.512003|35.490975|7.848850|0.075508|0.082309|0.065662|0.058837|0.056129|0.066259|0.095505|0.067469|0.056808|0.058902|0.074560|0.108212|0.082808|0.094087|0.087627|0.123083|0.500000| |4.454360|4.343929|3.459563|3.109928|3.282416|4.010876|4.858145|8.296769|9.878055|0.233762|10.274468|5.654442|4.857708|0.145923|4.811744|6.687229|3.497694|0.090138|3.119817|0.088975|2.517024|2.310756|1.972423|1.863860|1.992526|2.311815|2.557064|4.204412|0.095560|2.317872|2.499480|4.177239|7.806119|35.657389|0.109384|0.157527|0.106052|0.086349|0.074656|0.080366|0.109027|0.051188|0.046887|0.051556|0.066652|0.064013|0.057166|0.064459|0.066649|0.087638|0.122411|0.500000|
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