Version2.0 2020-07-29T22:58:26Z 10.1021/jm300687e Gaussian16 RevisionB.01 SBUNGAY 06-Jul-2020 #N HF/6-31G(d) OPT=(MaxStep=1) FREQ IOp(6/10=2,6/11=2,6/12=2) DUDE N[C@@H](CC(=O)N1CCNC[C@H]1Cc2ccccc2)Cc3cc(F)c(F)cc3F 308521 CHEMBL184636 RHF 6-31G(d) (6D,7F) N[C@@H](CC(=O)N1CCNC[C@H]1Cc2ccccc2)Cc3cc(F)c(F)cc3F C01[X(C21H24F3N3O1)] 150 C1 468 N[C@H](Cc1cc(F)c(cc1F)F)CC(=O)N1CCNC[C@H]1Cc1ccccc1 N[C@H](Cc1cc(F)c(cc1F)F)CC(=O)N1CCNC[C@H]1Cc1ccccc1 N[C@@H](CC(=O)N1CCNC[C@H]1Cc2ccccc2)Cc3cc(F)c(F)cc3F InChIKey=QIQKWBMHNYJKBE-IAGOWNOFSA-N InChI=1S/C21H24F3N3O/c22-18-12-20(24)19(23)10-15(18)9-16(25)11-21(28)27-7-6-26-13-17(27)8-14-4-2-1-3-5-14/h1-5,10,12,16-17,26H,6-9,11,13,25H2/t16-,17-/m1/s1 InChI=1/C21H24F3N3O/c22-18-12-20(24)19(23)10-15(18)9-16(25)11-21(28)27-7-6-26-13-17(27)8-14-4-2-1-3-5-14/h1-5,10,12,16-17,26H,6-9,11,13,25H2/t16-,17-/m1/s1 N[C@@H](CC(=O)N1CCNC[C@H]1Cc2ccccc2)Cc3cc(F)c(F)cc3F C01[X(C21H24F3N3O1)] 150 C01 468 N[C@H](Cc1cc(F)c(cc1F)F)CC(=O)N1CCNC[C@H]1Cc1ccccc1 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298.150 1.00000 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 7 6 1 6 6 8 7 6 6 7 6 6 1 6 6 6 6 6 6 6 6 6 6 6 9 6 9 6 6 9 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 14.00307 12.00000 1.00783 12.00000 12.00000 15.99491 14.00307 12.00000 12.00000 14.00307 12.00000 12.00000 1.00783 12.00000 12.00000 12.00000 12.00000 12.00000 12.00000 12.00000 12.00000 12.00000 12.00000 12.00000 18.99840 12.00000 18.99840 12.00000 12.00000 18.99840 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783 1.00783
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MUNgauss RevisionA2.0 retrievium 29-Jul-2020 DUDE N[C@@H](CC(=O)N1CCNC[C@H]1Cc2ccccc2)Cc3cc(F)c(F)cc3F 308521 CHEMBL184636 RHF 6-31G(d) (6D,10F) C1 391.187147 |X|Y|Z| 127.852118 42.965005 32.352522
56.222521 23 6 7 21 2
|53.358707| |17.895684|36.858105| |12.700489|17.598201|0.500000| |10.312719|12.386910|0.247603|36.858105| |8.447745|7.470292|0.193094|12.479115|36.858105| |8.621402|6.911848|0.205181|8.046701|15.820039|73.516695| |6.116862|5.027377|0.129689|7.699473|13.951342|15.010194|53.358707| |5.047944|4.298980|0.109655|6.553350|7.728789|9.563399|17.727442|36.858105| |4.212807|3.637993|0.098524|5.025397|5.822542|8.220233|10.587321|12.427779|36.858105| |3.767511|3.114235|0.086555|4.001366|4.983802|7.756146|9.046002|7.633260|13.122865|53.358707| |4.144756|3.337407|0.094337|4.199807|5.864768|9.807753|10.619774|6.647676|7.832240|17.792397|36.858105| |4.888122|3.790839|0.102873|4.930971|7.667963|12.071643|17.541718|7.907971|6.651772|10.437802|12.427484|36.858105| |4.341644|3.311109|0.087998|4.245010|5.807563|8.973984|12.760211|7.660010|6.205470|9.755099|8.973339|17.536500|0.500000| 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|5.337545|4.166881|0.123415|3.189892|2.728193|4.981917|3.129464|2.162741|2.047772|2.538229|1.935774|2.021063|0.051586|2.001332|1.732319|1.637441|1.465016|1.385896|1.441014|1.603739|5.015000|7.909527|13.847451|36.858105| |4.360141|3.431500|0.104308|2.765738|2.441069|4.497418|2.844282|1.977518|1.912985|2.398619|1.824631|1.870521|0.047770|1.853937|1.623496|1.554808|1.398791|1.317776|1.357869|1.498906|3.907818|5.265025|8.126448|14.358290|97.533100| |5.141735|3.735037|0.105462|2.901580|2.508316|4.566502|2.918952|2.013840|1.880759|2.345055|1.792971|1.897763|0.048942|1.900158|1.659509|1.562980|1.407637|1.341990|1.400756|1.553149|4.431523|6.831952|7.979296|13.832541|18.358084|36.858105| |4.158810|2.985357|0.084829|2.422075|2.154238|3.943603|2.554981|1.769720|1.668654|2.105792|1.609192|1.691537|0.043894|1.705432|1.512244|1.437099|1.306082|1.247172|1.294615|1.421527|3.388665|4.633585|5.306177|8.162919|15.982031|14.399262|97.533100| |5.950947|4.107313|0.109512|3.143283|2.668136|4.789024|3.102370|2.134408|1.949314|2.414274|1.847541|1.993400|0.051695|1.997501|1.735937|1.614030|1.451417|1.393640|1.469031|1.637791|4.996643|7.845665|6.890501|7.978819|11.931434|13.846588|18.326565|36.858105| |7.965892|5.567116|0.139077|3.998371|3.215804|5.648900|3.656884|2.508751|2.245451|2.731746|2.087427|2.282435|0.058904|2.257518|1.924957|1.765127|1.571590|1.509346|1.604668|1.811642|7.538013|13.785742|8.069045|6.992104|10.580103|8.055261|11.973050|13.819246|36.858105| |8.262979|5.314474|0.123962|4.054771|3.256849|5.587766|3.775693|2.597318|2.264110|2.746160|2.095077|2.340577|0.061224|2.315510|1.978102|1.789176|1.596973|1.550174|1.667330|1.888900|6.734104|8.140355|5.316961|4.697707|7.964339|5.340300|9.206414|8.220070|14.312909|97.533100| |25.868099|9.314611|0.182507|6.990214|5.658703|9.537611|6.010624|3.735924|3.024862|3.657911|2.913300|3.507057|0.089115|3.531126|2.814080|2.435564|2.097527|2.022381|2.222709|2.636112|7.002542|5.706939|4.218743|3.498956|6.469126|3.486878|6.444687|4.176216|5.614890|14.933024|0.500000| |25.925075|9.410812|0.230911|6.889344|6.847953|14.009115|6.600008|3.770528|3.156626|3.950426|3.309462|3.994223|0.096395|4.275654|3.255843|2.836467|2.376163|2.232175|2.418765|2.907969|5.738371|4.990252|4.127261|3.457705|6.598175|3.322349|6.248842|3.709184|4.591056|10.565785|0.325369|0.500000| |9.316535|8.814902|0.174237|17.534085|8.853153|10.777514|9.763761|6.738730|4.748102|5.105590|3.825425|4.639187|0.117823|3.967213|3.072000|2.607276|2.222414|2.144360|2.379499|2.869542|6.904333|4.549080|3.665373|2.941136|5.710740|2.756476|5.214365|3.063195|3.919036|9.499147|0.204657|0.167808|0.500000| |7.560342|8.816233|0.212710|17.513717|8.919711|11.340835|9.116956|6.692191|5.656525|5.758676|4.186820|4.526745|0.109602|3.746443|2.918252|2.573425|2.183349|2.058957|2.221048|2.634456|7.097979|4.653966|4.064979|3.148810|6.260257|2.797701|5.283015|2.954872|3.684784|8.155255|0.142965|0.141483|0.303443|0.500000| |4.470791|3.615859|0.091855|5.059020|5.802220|7.845041|12.507290|17.548517|8.808098|9.229401|5.868474|7.276672|0.238465|4.785373|3.980759|3.233732|2.773848|2.750003|3.164780|3.903093|3.128661|2.521907|2.271082|1.960254|4.043546|1.851870|3.697040|1.973216|2.293847|5.425160|0.094283|0.093071|0.153462|0.138298|0.500000| |5.406875|4.794305|0.117284|7.755991|7.232218|8.859840|12.306515|17.660562|8.794560|7.583201|4.942361|5.670417|0.152120|4.111375|3.284121|2.780241|2.379518|2.307000|2.569040|3.094458|4.183043|3.147219|2.781037|2.321679|4.721908|2.157890|4.224043|2.306424|2.759578|6.473066|0.112910|0.107496|0.243744|0.233279|0.304308|0.500000| |3.718058|3.179747|0.085450|4.212367|4.497332|6.565239|7.647825|8.802577|17.556828|12.505251|5.685940|4.993185|0.139011|3.564972|3.102277|2.775143|2.429286|2.332870|2.514797|2.903579|2.887258|2.367894|2.225759|1.919385|4.053466|1.769934|3.553635|1.832563|2.096793|4.771665|0.075121|0.076162|0.115136|0.133284|0.213529|0.209944|0.500000| |4.440771|4.003928|0.111706|5.505762|6.127160|8.809508|9.452119|8.878726|17.519985|12.543132|6.877905|5.705171|0.138336|4.065108|3.312341|2.990834|2.529075|2.350667|2.494653|2.933442|3.465675|2.786573|2.648670|2.233993|4.713573|2.016872|4.001507|2.068052|2.389238|5.316020|0.086407|0.091680|0.134943|0.186753|0.173729|0.215462|0.302765|0.500000| |3.441755|2.779474|0.076174|3.505415|4.236177|6.642202|7.751286|6.747773|9.407506|25.883732|9.401844|6.830664|0.206528|4.591963|4.271117|3.811938|3.294562|3.134448|3.372644|3.933146|2.427185|2.062797|1.951854|1.719779|3.657025|1.605062|3.262196|1.659782|1.867981|4.266454|0.069288|0.073446|0.094620|0.101021|0.192724|0.139797|0.231365|0.182937|0.500000| |3.634515|2.848935|0.080880|3.419563|4.523120|7.962560|7.645365|4.972705|5.697938|12.533150|17.594514|8.791949|0.211671|6.838918|6.591190|6.340050|4.826161|4.103589|4.167515|5.030948|2.388044|2.078381|1.990290|1.768943|3.782265|1.649605|3.365727|1.693568|1.887608|4.264175|0.071318|0.080853|0.088208|0.094067|0.131594|0.108815|0.128363|0.141488|0.231683|0.500000| |4.380781|3.604070|0.105838|4.430452|6.256097|11.277134|9.593001|5.773706|6.894977|12.468716|17.543472|8.864487|0.175161|6.613648|5.107050|4.783326|3.665905|3.158510|3.243385|3.941720|2.913100|2.486594|2.396859|2.084504|4.444128|1.905928|3.836186|1.943594|2.193917|4.871349|0.083231|0.097744|0.106717|0.124525|0.134180|0.128407|0.141100|0.198854|0.182347|0.302408|0.500000| |5.144535|3.739349|0.107609|4.224401|6.322753|14.236292|8.732516|4.421971|4.078539|6.220857|6.883439|8.790716|0.175547|17.665032|8.893692|7.238308|4.751638|3.972639|4.191300|5.612558|2.882893|2.533815|2.383247|2.112000|4.428071|1.987116|4.011867|2.065305|2.320757|5.256243|0.097840|0.125748|0.105201|0.104582|0.112636|0.104580|0.092475|0.111121|0.114020|0.178425|0.199816|0.500000| |5.633865|3.863243|0.103443|4.474255|6.493249|12.351758|9.774252|4.787649|3.925798|5.609016|5.469039|8.886040|0.208917|17.567646|8.911957|5.768263|4.256660|3.980561|4.683849|6.979482|2.988126|2.586247|2.346682|2.078026|4.275985|1.996932|4.015464|2.131308|2.427042|5.700148|0.113758|0.138068|0.119919|0.105176|0.129401|0.114239|0.091083|0.102165|0.108466|0.138741|0.141043|0.305156|0.500000| |3.500287|2.561592|0.074059|2.803095|3.609934|7.230873|5.250728|3.175466|3.197109|5.273836|5.368584|5.217425|0.128191|6.989299|8.919532|17.700231|8.929497|5.648634|4.962706|5.661401|2.131003|1.939279|1.872662|1.708772|3.672513|1.617810|3.346026|1.655929|1.806215|4.068972|0.067952|0.080953|0.072342|0.073529|0.085394|0.076274|0.076818|0.085885|0.102702|0.180257|0.147732|0.220687|0.147374|0.500000| |2.688536|1.949640|0.055394|2.106016|2.533186|4.810427|3.731225|2.431581|2.455858|3.973950|3.530407|3.452872|0.094635|4.082776|5.625658|8.920392|17.711231|8.916882|5.653067|4.964680|1.689814|1.562632|1.512435|1.404822|3.040866|1.347772|2.829246|1.379923|1.482903|3.366954|0.053379|0.060464|0.056103|0.055954|0.068110|0.059775|0.062028|0.064902|0.082200|0.117830|0.092831|0.113055|0.098261|0.216004|0.500000| |2.488001|1.784071|0.049469|1.942199|2.280110|4.167929|3.443289|2.309921|2.261433|3.557754|2.987013|3.107454|0.091618|3.532764|4.916717|5.639538|8.908365|17.715385|8.899331|5.641978|1.570668|1.447912|1.382192|1.286603|2.763701|1.249474|2.627409|1.294630|1.392964|3.216647|0.050599|0.055223|0.053282|0.051327|0.067314|0.057185|0.058439|0.058303|0.076647|0.095356|0.075456|0.090443|0.090604|0.124180|0.214597|0.500000| |2.805088|1.988782|0.053796|2.208656|2.595250|4.592097|4.058287|2.725228|2.529671|3.866606|3.200606|3.644726|0.115550|4.083340|5.623011|4.963386|5.654389|8.907479|17.709285|8.928456|1.744799|1.583932|1.481954|1.367545|2.896738|1.336934|2.788356|1.407062|1.533169|3.607730|0.058361|0.062098|0.062238|0.057424|0.082719|0.067103|0.065380|0.063551|0.085002|0.097162|0.078127|0.096468|0.110820|0.107679|0.124159|0.214491|0.500000| |3.768249|2.651327|0.070342|3.058441|3.794572|6.543789|6.299530|3.929311|3.364098|5.029108|4.380663|5.956582|0.203468|6.985973|8.903316|5.660788|4.962801|5.648113|8.942160|17.686233|2.243818|1.979882|1.815304|1.642611|3.425957|1.598835|3.278378|1.703024|1.898808|4.515137|0.079212|0.084967|0.087141|0.076933|0.121425|0.093563|0.083454|0.082801|0.108302|0.124333|0.103340|0.141723|0.204268|0.124235|0.107683|0.124202|0.216215|0.500000| |7.682024|8.841649|0.213300|7.102438|4.654981|7.418112|5.093420|3.687849|3.342806|3.775374|2.774247|2.946554|0.074410|2.688170|2.217426|2.016101|1.762269|1.674753|1.783336|2.046993|17.542855|8.961518|7.108104|4.732041|8.727977|3.995132|7.066705|4.229069|5.717461|11.385654|0.143141|0.127727|0.174281|0.220537|0.087478|0.120583|0.085978|0.104845|0.069410|0.066787|0.082426|0.076510|0.077344|0.057758|0.045951|0.042516|0.046813|0.059480|0.500000| |9.526518|8.835420|0.174241|6.944067|4.544158|7.123985|5.089510|3.624670|3.073207|3.519573|2.619695|2.923912|0.075518|2.721107|2.250040|2.006391|1.762011|1.700084|1.839460|2.121918|17.557635|8.937960|5.658069|4.222941|7.549351|3.994518|7.061527|4.741645|7.172925|17.386166|0.204711|0.144531|0.207660|0.175596|0.089339|0.119609|0.079378|0.091021|0.066269|0.063674|0.075445|0.075576|0.081280|0.056472|0.045541|0.043146|0.048737|0.062917|0.303938|0.500000| |6.069155|5.588219|0.179187|4.212504|3.443459|6.187839|3.829050|2.663882|2.559790|3.096832|2.340952|2.404926|0.060321|2.310768|1.955524|1.840101|1.622757|1.521963|1.584045|1.783790|6.926365|8.872815|17.727431|9.034305|16.733331|5.689345|9.653132|4.962507|5.688590|9.575213|0.106554|0.108619|0.101839|0.122072|0.065030|0.080450|0.065942|0.080319|0.057120|0.058183|0.071394|0.068188|0.065584|0.053758|0.043063|0.038951|0.041423|0.050654|0.209244|0.142232|0.500000| |5.240268|3.503549|0.092505|2.791394|2.419880|4.339132|2.865669|1.976064|1.799872|2.245793|1.718822|1.862351|0.048738|1.879798|1.652514|1.537003|1.392176|1.344913|1.419561|1.573535|4.083422|5.610511|4.964605|5.663977|9.600427|8.930292|16.503765|17.762073|8.909626|16.744717|0.105776|0.092943|0.076994|0.072538|0.051382|0.058980|0.047223|0.052464|0.043224|0.044083|0.049808|0.053634|0.055983|0.043559|0.036781|0.034831|0.037965|0.045555|0.097509|0.112649|0.107745|0.500000|
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