Version2.1 2021-01-09T10:12:48Z 10.1021/jm300687e Gaussian16 RevisionB.01 PWARBURT 01-Jan-2021 #N HF/6-31G(d) OPT=(MaxStep=1) FREQ IOp(6/10=2,6/11=2,6/12=2) DUDE c1ccc(cc1)Oc2ccc(cn2)NC(=O)[C@H]3CCCC[NH+]3Cc4cc(cs4)C#CCO C20202967 RHF 6-31G(d) (6D,7F) c1ccc(cc1)Oc2ccc(cn2)NC(=O)[C@H]3CCCC[NH+]3Cc4cc(cs4)C#CCO C01[X(C25H26N3O3S1)] 168 C1 536 OCC#Cc1csc(c1)C[NH+]1CCCC[C@@H]1C(=O)Nc1ccc(nc1)Oc1ccccc1 OCC#Cc1csc(c1)C[NH+]1CCCC[C@@H]1C(=O)Nc1ccc(nc1)Oc1ccccc1 OCC#Cc1csc(C[NH+]2CCCC[C@@H]2C(=O)Nc3ccc(Oc4ccccc4)nc3)c1 InChIKey=PFCCXKZKOGCNRA-HSZRJFAPSA-O InChI=1S/C25H25N3O3S/c29-14-6-7-19-15-22(32-18-19)17-28-13-5-4-10-23(28)25(30)27-20-11-12-24(26-16-20)31-21-8-2-1-3-9-21/h1-3,8-9,11-12,15-16,18,23,29H,4-5,10,13-14,17H2,(H,27,30)/p+1/t23-/m1/s1 InChI=1/C25H25N3O3S/c29-14-6-7-19-15-22(32-18-19)17-28-13-5-4-10-23(28)25(30)27-20-11-12-24(26-16-20)31-21-8-2-1-3-9-21/h1-3,8-9,11-12,15-16,18,23,29H,4-5,10,13-14,17H2,(H,27,30)/p+1/t23-/m1/s1/fC25H26N3O3S/h27-28H/q+1 c1ccc(cc1)Oc2ccc(cn2)NC(=O)[C@H]3CCCC[NH+]3Cc4cc(cs4)C#CCO C01[X(C25H26N3O3S1)] 168 C01 536 OCC#Cc1csc(c1)C[NH+]1CCCC[C@@H]1C(=O)Nc1ccc(nc1)Oc1ccccc1 OCC#C[C]1=[CH]SC(=[CH]1)C[NH]1CCCC[C@@H]1C(=O)N[C]1[CH][CH][C]([N][CH]1)O[C]1[CH][CH][CH][CH][CH]1 OCC#Cc1csc(C[NH]2CCCC[C@@H]2C(=O)N[C]3[CH][CH][C]([N][CH]3)O[C]4[CH][CH][CH][CH][CH]4)c1 InChIKey=LRJSCNFPKPIQNT-HSZRJFAPSA-N InChI=1S/C25H26N3O3S/c29-14-6-7-19-15-22(32-18-19)17-28-13-5-4-10-23(28)25(30)27-20-11-12-24(26-16-20)31-21-8-2-1-3-9-21/h1-3,8-9,11-12,15-16,18,23,28-29H,4-5,10,13-14,17H2,(H,27,30)/t23-/m1/s1 InChI=1/C25H26N3O3S/c29-14-6-7-19-15-22(32-18-19)17-28-13-5-4-10-23(28)25(30)27-20-11-12-24(26-16-20)31-21-8-2-1-3-9-21/h1-3,8-9,11-12,15-16,18,23,28-29H,4-5,10,13-14,17H2,(H,27,30)/t23-/m1/s1/f/h27H 3077.4945350814 -1747.029404 1-A 24200.6016 118 418 536 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MUNgauss RevisionA2.0 retrievium 09-Jan-2021 DUDE c1ccc(cc1)Oc2ccc(cn2)NC(=O)[C@H]3CCCC[NH+]3Cc4cc(cs4)C#CCO C20202967 RHF 6-31G(d) (6D,10F) C1 448.169489 |X|Y|Z| 77.675324 129.051566 38.893810
73.053711 27 6 7 8 16 22 3 1 1
|36.858105| |13.746427|36.858105| |7.926419|13.751628|36.858105| |6.921057|7.997830|13.808766|36.858105| |7.926684|6.866894|7.908575|13.809198|36.858105| |13.746827|7.942567|6.866543|7.997554|13.751206|36.858105| |4.605135|5.225961|7.990030|13.747255|7.990612|5.225998|73.516695| |3.813791|4.251703|5.911525|8.046833|5.907126|4.250010|25.452238|36.858105| |3.009427|3.302963|4.289053|5.266760|4.287012|3.301998|14.608494|13.567598|36.858105| |2.595301|2.809926|3.467408|4.022134|3.467351|2.809875|9.519064|8.034576|13.946685|36.858105| |2.631512|2.830600|3.414075|3.874861|3.412624|2.829761|8.411500|7.065179|8.000863|13.629097|36.858105| |3.131507|3.379445|4.117001|4.717375|4.110564|3.375878|9.716200|8.442619|7.037976|8.018321|13.888836|36.858105| |3.914709|4.306091|5.640401|7.021768|5.634895|4.303604|14.802036|14.605757|7.980909|6.893828|8.022559|14.372669|53.358707| |2.239829|2.377827|2.754506|3.022244|2.757026|2.379432|6.207645|4.617863|5.143962|7.715448|13.317459|7.841244|7.071557|53.358707| |2.025845|2.174146|2.492985|2.646621|2.394295|2.108018|5.361900|3.801502|4.263563|5.953166|7.809168|5.566207|5.613874|19.391771|36.858105| |2.028930|2.217153|2.563806|2.664787|2.357755|2.080344|5.430951|3.797914|4.307036|5.768746|6.707188|5.070036|5.437422|11.467875|15.854484|73.516695| |1.769501|1.871063|2.091732|2.205126|2.045986|1.838241|4.351289|2.947723|3.229217|4.162928|5.012081|4.032576|4.324996|10.640368|12.418175|14.393679|36.858105| |1.768984|1.850755|2.046849|2.164718|2.038741|1.844779|4.204420|2.832083|3.013153|3.785443|4.700903|3.988090|4.253049|9.829921|8.690179|10.600916|17.587552|0.500000| |1.633119|1.714892|1.915077|2.038018|1.907007|1.709111|4.061876|2.704476|3.061189|3.919511|4.281170|3.397143|3.810855|8.140710|7.642177|10.702238|12.375383|0.243031|36.858105| |1.451858|1.515144|1.665909|1.755461|1.660834|1.511337|3.434791|2.225101|2.459281|2.983987|3.206434|2.705084|3.133647|5.614022|4.925712|7.607417|7.448566|0.183472|12.483928|36.858105| |1.396034|1.467576|1.606113|1.665374|1.564350|1.435641|3.230422|2.072083|2.261260|2.687160|2.884852|2.495713|2.924806|4.888273|4.476270|7.479194|6.452663|0.154848|7.644617|12.493563|36.858105| |1.473851|1.556062|1.698873|1.746205|1.633497|1.505565|3.356151|2.165840|2.315149|2.747796|3.065956|2.706644|3.125877|5.281811|5.011690|8.362339|7.574356|0.187645|6.537338|7.610556|12.534823|36.858105| |1.662702|1.772053|1.961236|2.019019|1.862993|1.698880|3.921478|2.590759|2.782134|3.404284|3.941805|3.389956|3.786451|7.169473|7.843170|12.907687|12.684337|0.253177|7.572147|6.460174|7.585555|12.653294|53.358707| |1.670783|1.796739|2.003489|2.051618|1.871378|1.699989|4.022488|2.652552|2.894914|3.542087|3.956570|3.352671|3.803483|6.864824|7.765744|15.428091|9.433846|0.183250|6.952187|5.750025|6.938070|9.197814|25.631444|0.500000| |1.744453|1.867742|2.048984|2.075668|1.911121|1.761963|3.950163|2.596871|2.680867|3.179551|3.804765|3.501318|3.911050|6.553820|6.432186|11.089682|7.591825|0.199195|4.912061|4.375050|4.940599|7.647084|17.049214|0.259656|36.858105| |1.654186|1.786063|1.944166|1.931126|1.768030|1.647153|3.642069|2.339047|2.401377|2.752390|3.144191|2.963065|3.460609|4.999925|4.659899|8.971530|5.010024|0.128624|3.810251|3.570439|4.262186|6.130277|10.366709|0.208265|12.730669|36.858105| |1.699670|1.861466|2.039018|1.997645|1.802073|1.676671|3.780416|2.410557|2.481071|2.799805|3.112051|2.941827|3.513081|4.715541|4.350618|9.145094|4.255538|0.105883|3.414078|3.128682|3.657481|4.693051|7.916327|0.182774|7.513583|14.124637|36.858105| |1.562495|1.707983|1.843908|1.787692|1.623188|1.528803|3.341237|2.081217|2.126224|2.336631|2.533947|2.437443|2.998676|3.738352|3.280590|6.660941|3.270393|0.083683|2.782567|2.651421|3.119174|3.818652|5.749611|0.128489|5.053126|8.192499|13.241659|36.858105| |1.452472|1.568921|1.675003|1.632990|1.503097|1.425557|3.028349|1.877637|1.909107|2.096519|2.287040|2.212480|2.719431|3.418365|2.951171|5.716361|3.079296|0.081062|2.641100|2.605559|3.112615|3.883495|5.439655|0.114950|4.835472|7.717736|8.241117|14.083744|36.858105| |1.471470|1.573000|1.680963|1.662265|1.544061|1.459570|3.088282|1.939619|1.972922|2.206688|2.467691|2.373413|2.849524|3.828938|3.340725|6.178006|3.704135|0.100304|3.059136|3.072736|3.733870|5.127971|6.903303|0.134142|6.710852|10.972351|7.450102|7.439583|11.098654|388.023441| |1.544132|1.701619|1.834124|1.757003|1.585479|1.498252|3.276686|2.009328|2.051438|2.207466|2.333935|2.259390|2.849022|3.334816|2.853935|5.866657|2.760220|0.070520|2.430716|2.305060|2.648670|3.062262|4.573545|0.103585|3.777311|5.178648|7.536807|13.286169|7.708441|34.252002|36.858105| |1.516547|1.678679|1.804234|1.714373|1.542992|1.462996|3.188819|1.928621|1.967308|2.081696|2.161172|2.102304|2.700407|3.025710|2.538056|5.205150|2.422712|0.062067|2.181466|2.066976|2.334611|2.614131|3.871961|0.087501|3.101779|3.945354|5.282348|7.267625|5.318753|26.404493|16.040501|36.858105| |1.466224|1.626750|1.738731|1.639999|1.476133|1.406510|3.037374|1.806514|1.839608|1.911191|1.949214|1.906497|2.496244|2.680083|2.199856|4.464478|2.085220|0.053722|1.917318|1.819469|2.019107|2.200401|3.226183|0.072299|2.525015|3.035511|3.798081|4.653618|3.806128|20.548424|7.161712|12.938161|36.858105| |1.466457|1.630395|1.759949|1.668380|1.494393|1.413366|3.126517|1.855484|1.917425|1.986785|1.987532|1.918259|2.522966|2.713941|2.230840|4.580280|2.095062|0.053359|1.959786|1.848786|2.040347|2.176085|3.200949|0.072835|2.428737|2.840398|3.525970|4.027713|3.295415|18.682958|5.629151|8.161989|13.631680|73.516695| |17.726018|8.912958|5.641796|4.977583|5.641945|8.913367|6.498855|3.147896|2.575147|2.272367|2.317637|2.715325|4.435206|2.745315|1.842817|3.277680|1.632550|0.045516|1.509693|1.355346|1.308428|1.382097|2.103727|0.043028|1.627063|1.552498|1.591309|1.476347|1.381281|9.934769|1.461595|1.438685|1.396166|2.470843|0.500000| |8.911079|17.723318|8.935318|5.675771|4.949315|5.646779|7.505959|3.602738|2.917734|2.540855|2.570438|3.014693|5.001219|2.999560|2.052284|3.756177|1.780936|0.048845|1.629210|1.450276|1.417898|1.508630|2.328316|0.048307|1.816034|1.760754|1.848594|1.714766|1.573786|11.107828|1.723795|1.712267|1.671550|2.963675|0.214798|0.500000| |5.629445|8.865355|17.733084|8.951411|5.644556|4.950101|13.010097|5.834851|4.434070|3.596911|3.497573|4.113712|7.388696|3.841766|2.606744|4.880415|2.164017|0.058115|1.974227|1.712014|1.664720|1.765133|2.791984|0.058856|2.146398|2.059579|2.195928|1.984615|1.780252|12.556023|1.994222|1.973240|1.907840|3.450377|0.123810|0.213917|0.500000| |5.629773|4.950288|5.644404|8.951013|17.733169|8.866060|13.010332|5.826852|4.429788|3.596585|3.494614|4.102120|7.376265|3.848098|2.417818|4.170994|2.077086|0.057691|1.958650|1.702286|1.585372|1.642032|2.539237|0.051850|1.890196|1.731897|1.750570|1.572090|1.462385|10.764579|1.527018|1.481044|1.413020|2.550366|0.123818|0.107487|0.124520|0.500000| |8.910961|5.646721|4.949172|5.675752|8.935343|17.723833|7.506218|3.601010|2.916620|2.540845|2.569383|3.010277|4.997638|3.002718|1.955982|3.401712|1.731441|0.048594|1.620451|1.444375|1.367788|1.429397|2.175208|0.044192|1.652440|1.542125|1.558067|1.426705|1.340754|9.806479|1.394146|1.359847|1.307743|2.332405|0.214799|0.124113|0.107485|0.213945|0.500000| |2.857500|3.127631|4.016876|4.864410|4.015188|3.126801|13.383224|8.870502|17.770749|8.890224|5.645641|5.043761|7.772811|5.631397|3.617160|6.616932|2.857697|0.073783|2.794703|2.290317|2.115285|2.131873|3.413818|0.073102|2.393250|2.184012|2.273472|1.981615|1.781985|12.954878|1.937192|1.878896|1.780238|3.334803|0.068360|0.077301|0.116105|0.116006|0.077273|0.500000| |2.280497|2.451490|2.951988|3.344238|2.952438|2.451731|7.630536|5.670807|8.964923|17.728470|8.854486|5.675847|6.756137|9.577232|6.020255|10.502084|4.350314|0.106306|4.384580|3.265332|2.895363|2.870435|4.788723|0.103433|3.139326|2.728097|2.773159|2.321939|2.086339|15.606073|2.195173|2.071691|1.903629|3.555263|0.056256|0.062458|0.085473|0.085494|0.062468|0.212479|0.500000| |3.035402|3.228282|3.749403|4.119750|3.741706|3.223376|7.825347|5.933049|5.036310|5.664622|8.940317|17.699495|12.698798|9.760123|5.334745|8.401265|4.082319|0.117117|3.313186|2.692050|2.504619|2.782569|4.738679|0.093050|3.760399|3.127087|3.031806|2.506178|2.303296|17.881583|2.287561|2.107324|1.894600|3.340110|0.074424|0.081219|0.102993|0.102623|0.081041|0.109063|0.124097|0.500000| |2.154200|2.244204|2.553144|2.823585|2.653984|2.311459|5.676354|4.092177|4.422579|6.104493|9.118102|6.658630|6.314856|26.016888|9.453293|10.839482|7.503474|0.222793|6.008669|4.259024|3.561325|3.808431|6.661041|0.124124|4.471155|3.382009|3.104364|2.516260|2.355419|19.092904|2.237188|2.032573|1.808798|3.238746|0.054262|0.057672|0.071389|0.076678|0.060366|0.101667|0.159179|0.183123|0.500000| |1.677594|1.746657|1.954074|2.112723|1.996523|1.776638|4.236069|2.836640|3.239089|4.199342|4.559015|3.558336|3.980885|8.682950|6.885698|9.305196|8.927533|0.216411|17.577967|8.797561|5.529806|4.901612|7.566202|0.142736|4.112017|3.241347|2.948318|2.447581|2.329509|18.960354|2.174315|1.976464|1.761233|3.203152|0.042964|0.045724|0.055395|0.057667|0.046982|0.081893|0.131643|0.095356|0.192991|0.500000| |1.635388|1.730926|1.948136|2.067273|1.912560|1.705929|4.172379|2.771145|3.221720|4.146485|4.274569|3.332781|3.808819|7.599839|7.365664|11.757541|8.879568|0.173582|17.539173|8.859233|6.875945|5.702121|9.169850|0.200100|4.497498|3.705265|3.480926|2.843779|2.638867|20.948891|2.529379|2.288414|2.019706|3.728054|0.041880|0.045752|0.056316|0.054397|0.044703|0.082923|0.134948|0.087874|0.144585|0.303625|0.500000| |1.432341|1.483729|1.619313|1.709404|1.633698|1.494721|3.310831|2.137380|2.321416|2.783544|3.050553|2.633621|3.047752|5.338127|4.442879|6.694776|6.667288|0.191582|8.820286|17.526758|8.842981|6.860740|7.752855|0.133699|4.202285|3.376918|2.899843|2.483965|2.486882|21.296904|2.152099|1.930439|1.703794|3.047303|0.037267|0.039416|0.045877|0.046632|0.039895|0.059780|0.082694|0.074112|0.117447|0.213619|0.173477|0.500000| |1.384911|1.441159|1.583051|1.673133|1.588668|1.445372|3.282760|2.104559|2.347206|2.810580|2.920254|2.469767|2.916462|4.900998|4.122185|6.582985|5.469248|0.137001|8.884193|17.590122|8.827868|5.525277|6.592794|0.127879|3.535962|3.024052|2.737245|2.376962|2.329934|18.951987|2.113276|1.922917|1.716619|3.129159|0.035954|0.038300|0.045126|0.045424|0.038483|0.061698|0.086847|0.067402|0.102976|0.211150|0.216575|0.303428|0.500000| |1.297985|1.358320|1.474299|1.524084|1.441453|1.332609|2.930998|1.856848|2.006560|2.336699|2.490674|2.200978|2.617754|4.102396|3.589090|6.051764|4.835844|0.124765|5.526144|8.790144|17.577889|8.998561|7.570535|0.142456|4.136279|3.741348|3.226738|2.868956|2.946663|25.098699|2.458585|2.182601|1.903084|3.402312|0.033970|0.036566|0.042306|0.040581|0.035432|0.052550|0.069366|0.061691|0.084143|0.123225|0.140359|0.213646|0.209504|0.500000| |1.390254|1.470157|1.616163|1.669985|1.557019|1.425398|3.259996|2.083662|2.300601|2.725072|2.851429|2.448356|2.900481|4.705925|4.367319|7.742851|5.699896|0.130363|6.873437|8.821282|17.530455|8.861965|9.248381|0.201345|4.544294|4.162283|3.772928|3.240809|3.150477|25.500879|2.801595|2.484384|2.151515|3.923634|0.036138|0.039537|0.046858|0.043717|0.037590|0.060362|0.082786|0.067212|0.092486|0.140147|0.202912|0.173243|0.213768|0.303687|0.500000| |1.459134|1.528908|1.656866|1.707018|1.612504|1.493988|3.250434|2.092208|2.204548|2.595595|2.943078|2.651014|3.055764|5.080598|4.551393|7.270903|6.856055|0.199662|5.767910|6.883697|8.832060|17.599653|12.430645|0.180948|7.153457|5.475348|4.104993|3.428799|3.596954|35.221795|2.767148|2.379951|2.022466|3.520352|0.038136|0.041129|0.047428|0.045127|0.039598|0.056174|0.074208|0.077152|0.105616|0.129286|0.132593|0.203508|0.140531|0.215523|0.173424|0.500000| |1.421652|1.506957|1.637042|1.664205|1.552328|1.440363|3.176665|2.027052|2.149233|2.500349|2.754652|2.481806|2.916162|4.553284|4.233643|7.504875|5.587473|0.140684|4.905643|5.513736|8.788141|17.667960|12.421479|0.224375|7.188663|7.040888|5.289454|4.455617|4.702902|45.603037|3.457082|2.891932|2.390428|4.159470|0.037171|0.040878|0.047485|0.043066|0.037949|0.055377|0.072062|0.070919|0.089817|0.107974|0.128017|0.140105|0.123274|0.213307|0.213881|0.301520|0.500000| |1.935193|2.086559|2.312237|2.343496|2.135814|1.954680|4.472126|2.998048|3.055491|3.660804|4.596012|4.286551|4.629604|7.940664|7.754909|13.291768|7.460262|0.196870|4.704826|3.930521|4.140206|5.624083|12.317729|0.216874|17.698320|9.002850|6.934319|4.645058|4.227230|37.329350|3.648156|3.055258|2.517683|4.322332|0.049760|0.056085|0.067470|0.058395|0.050526|0.074175|0.097461|0.130510|0.143979|0.114143|0.121526|0.104991|0.090424|0.096982|0.108580|0.148972|0.144395|0.500000| |1.684247|1.782435|1.932147|1.964498|1.835968|1.706395|3.694712|2.407649|2.454343|2.874138|3.448840|3.250957|3.655138|5.920034|5.308918|8.584821|6.667590|0.204016|4.536009|4.271369|4.717174|7.329779|12.338723|0.182625|17.630652|8.833681|5.602078|4.271048|4.390244|46.592877|3.273719|2.736839|2.268950|3.853532|0.043895|0.048109|0.055553|0.050644|0.044806|0.061051|0.078457|0.099251|0.118805|0.108877|0.110713|0.120809|0.095560|0.114378|0.114729|0.228630|0.186767|0.301636|0.500000| |1.826116|2.022370|2.250189|2.200916|1.955258|1.800994|4.218355|2.717617|2.821337|3.200200|3.532581|3.299419|3.933382|5.236414|4.908720|11.260398|4.411596|0.106648|3.541990|3.112037|3.512680|4.293809|7.676682|0.188161|6.689272|8.883718|17.727951|8.603507|5.736345|37.635286|6.745276|5.184104|3.862283|6.619603|0.047103|0.055625|0.068180|0.052585|0.046119|0.071427|0.087703|0.092487|0.092650|0.085576|0.103011|0.079075|0.076288|0.084662|0.102530|0.103750|0.126817|0.194451|0.137298|0.500000| |1.361863|1.465948|1.552440|1.509158|1.396435|1.332978|2.781870|1.706338|1.729490|1.878139|2.027968|1.974551|2.458133|2.996338|2.532819|4.850309|2.642812|0.070324|2.325607|2.326643|2.753403|3.311060|4.497981|0.094340|3.841063|5.421714|5.690961|8.768677|17.795081|55.524978|6.715042|5.083385|3.784240|5.695895|0.036172|0.041022|0.045705|0.037728|0.034947|0.045178|0.051972|0.056979|0.057873|0.057675|0.064579|0.062136|0.058642|0.074049|0.077446|0.086734|0.109792|0.095328|0.100513|0.122688|0.500000| |1.532386|1.710930|1.818447|1.694619|1.520680|1.456968|3.109981|1.835884|1.846308|1.896457|1.938215|1.922969|2.543513|2.632163|2.131247|4.301250|1.997785|0.051874|1.825517|1.720407|1.883586|2.058952|3.046644|0.067547|2.415680|2.857685|3.529274|4.178544|3.468379|19.240874|5.993151|9.109159|17.535330|16.440790|0.040623|0.049271|0.055689|0.040169|0.037524|0.049574|0.051927|0.053198|0.049358|0.046984|0.053112|0.045043|0.045051|0.049261|0.055203|0.053126|0.061410|0.067980|0.060688|0.100951|0.095480|0.500000| |1.358740|1.495168|1.585518|1.501534|1.363686|1.305580|2.769168|1.640878|1.669687|1.734700|1.770704|1.733054|2.269406|2.449129|2.000117|3.993969|1.927050|0.050013|1.786765|1.719585|1.915440|2.076391|2.980964|0.066064|2.323118|2.782906|3.359284|4.177810|3.636949|19.595938|6.001799|9.118357|17.538290|16.433491|0.036121|0.042674|0.047898|0.036373|0.033900|0.044999|0.048138|0.048038|0.046354|0.045672|0.051995|0.044942|0.045251|0.050748|0.056505|0.053352|0.063024|0.063573|0.058851|0.092140|0.104867|0.301555|0.500000| |1.423663|1.581470|1.698095|1.604767|1.441011|1.368404|2.994539|1.758680|1.812192|1.858148|1.846173|1.790535|2.378040|2.502064|2.030043|4.119242|1.907557|0.048890|1.799662|1.702803|1.861596|1.966667|2.872790|0.064719|2.170413|2.490913|3.005566|3.372718|2.857001|16.577019|4.457149|6.020945|9.870950|35.724816|0.037600|0.045091|0.051963|0.038390|0.035333|0.049607|0.051918|0.048621|0.046894|0.046340|0.053378|0.044035|0.045323|0.048787|0.055713|0.050102|0.058304|0.060548|0.054409|0.087831|0.078186|0.228407|0.228429|0.500000|
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